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EU Commission report on cancer mechanobiology research from Prof Knight's group at QMUL

The EU Commission have published a report on some of the research into cancer mechanobiology taking place in the Bioengineering Division within School of Engineering and Materials Science at QMUL. The report entitled 'Mechanobiology of METAstatic and DORMant cancer cells in bone marrow lesions', describes research conducted by Dr Verbruggen ... [more]

Premature baby in an incubator. Credit: CatEyePerspective/iStock.com

New bioengineering approach to fix fetal membranes

The study, published in the journal Prenatal Diagnosis, found that these molecules, known as peptide amphiphiles (PAs) self-assemble to form a ‘plug’ that seals holes within the fetal membranes, and could potentially help repair any damage. For the study, the researchers established a fetal membrane defect model, which mimics the ... [more]

Modelling of real-world disease breakout group (from top left on screen: Elisabete Silva; Andrew Pitsillides; Gerard Cummins; Charareh Pourzand; Alessandra Granata; John Greenman; Paul Holloway; Tomasz Kostrzewski; Valerie Speirs)

Organ on chip funding sandpit goes virtual

Thanks to the new world of on-line events, the OOACT Network's sandpit – originally planned face to face in April this year – was run successfully in MS Teams from 29 September to 1 October. This interactive funding sandpit event provided a great opportunity for 32 senior academics and industrialists from across the UK to ... [more]

confocal microscopy image of primary cilia in healthy cells but which are disrupted in Jeune syndrome

Funding awarded to Prof Knight to develop a new treatment for the rare disease, Jeune Syndrome

This project funded by Queen Mary Innovations, will identify compounds for the treatment of a rare genetic disease, Jeune Syndrome, that disrupts skeletal formation. The disease is caused by mutation in the genes that regulate primary cilia – the tiny hair-like cellular structures that coordinate a variety of important signalling pathways. ... [more]

Organ on a chip network logo

QM hosts new Organ-on-a-chip Research symposia

QMUL has launched a new e-symposia series with research presentations related to organ-on-a-chip and other predictive in vitro models. The symposia are part of the UK Organ-on-a-chip Technologies Network which is funded via the Technology Touching Life scheme and directed by Prof Hazel Screen and Prof Martin Knight, both bioengineers ... [more]

Thomas Iskratsch in the Journal of Cell Science as a

Thomas Iskratsch is featured in the current issue of the Journal of Cell Science as part of the "Cell Scientist to Watch" series.

Thomas Iskratsch is featured in the current issue of Journal of Cell Science as part of the "Cell Scientist to Watch" series. The series looks at "cell biologists who are in the earlier stages of their careers, and who [the Journal of Cell Science think] are making important contributions to ... [more]

The launch symposium celebrated the start of the new Centre for In Vitro Predictive Models

Successful Launch of QMUL Centre for Predictive in vitro Models

The Centre for Predictive in vitro Models (CPM) was officially launched on Wednesday 22nd with an successful virtual symposium. More than 330 registrated attendees joined in to celebrate the occasion, listening to talks and participating in stimulating discussions. Introductory words from the vice principal for the faculty of Science and Engineering, ... [more]

Emulate's organs-on-chips technology. Credit: Emulate

Using Organs-on-chips technology to accelerate COVID-19 research

The Queen Mary & Emulate Organs-on-Chips Centre is involved in a new initiative to use miniaturised living systems with human cells, known as organ-chips, in the fight against COVID-19. As part of this initiative, Emulate, Inc have donated blank Organ-Chips to the UK Organ-on-a-chip Technologies Network to support the development of ... [more]

New Paper!

Congratulations Connor for the acceptance of your first paper in Frontiers Bioengineering & Bitechnology: "Force transmission between the gastrocnemius and soleus sub-tendons of the Achilles tendon in rat” Gains CC, Correia CC, Baan GC, Noort W, Screen HRC, Maas H. (2020) Frontiers in Bioengineering and Biotechnology [more]

Clockwise, from top left: keratinocytes deforming protein nanosheets on top of an oil droplet (Gautrot lab), fibroblasts forming a network in a hydrogel (S.Lopategui, Iskratsch lab), cardiomyocytes contracting soft polymers (with titin doublets resolved at approximately 160nm distance, I.Xanthis, Iskratsch lab) and flat worm larvaes (A.Carrillo-Baltodano, Martin lab, SBCS), all imaged with the Nikon SoRa super-resolution spinning disc microscope

New state-of-the-art microscope to support research in the School of Engineering and Materials Science

Queen Mary underlined its strong commitment to the ongoing research in SEMS by investing into a £375K state-of-the-art super-resolution spinning disc microscope. Microscopy imaging approaches have long been a major research strength within the school, facilitating new collaborative links and supporting significant research funding and outputs in leading journals. The ... [more]

covid-19 virus and organ-chip (not to scale)

Queen Mary + Emulate Organs-on-Chips Centre supports COVID-19 initiative

The Queen Mary + Emulate Organs-on-Chips Centre is supporting a new initiative to use predictive in vitro models, also known as organ-chips, in the fight against COVID-19. Emulate, Inc is participating in the Organs-on-Chips against COVID-19 initiative (#OoCovid) and donating a set of Organ-Chips to the UK Organ-on-a-Chip Technologies Network which ... [more]

‘Magnetically responsive’ microscopic drug carrier

Researchers use magnetism to keep drugs at disease sites

The researchers were able to use magnetism to hold ‘magnetically responsive’ microscopic drug carriers at chosen sites, even in the presence of external forces, such as flowing liquid, which would normally displace them. They also found that magnetism restricted the movement of cells containing these drug capsules. This suggests that ... [more]

New date announced

New date for World Biomaterials Congress 2020 announced

The World Biomaterials Congress with Liz Tanner as a member of the Executive Committee has been postponed from May to December 2020 due to Covid-19. The new dates are Thursday 11th December to Wednesday 16th December. The programme will be similar but there will be new events announced nearer the time. [more]

THEUNSEEN and Lucideon logos

Double Success with KTP Grants Awarded

SEMS has secured two new Knowledge Transfer Partnership (KTPs) grants this month. This success represents a total of about £500K in grant funding and a doubling of SEMS portfolio to a total of 4 live KTP projects. This is all of the live KTP projects running at QMUL currently. The first ... [more]

The microwave sensor technology measuring a droplet of blood.

Researchers use microwaves to measure signs of dehydration

The researchers are now looking to develop the technology into a wearable device that could be used by athletes, or in healthcare settings, to monitor hydration in real time. For the study, the research team utilised a microwave-based measurement system, developed by NPL, to examine changes to salts and proteins ... [more]

Thomas (right) and Corina (middle) being congratulated by Dr Adrian Briggs.

3rd Year Project Poster Winners Announced

The Spring Industrial Liaison Forum one again played host to the 3rd year project student poster showcase. Two winners were selected from the 300+ posters that were submitted. These were from Thomas Kellock for his poster on "Spiral Microfluidics for Circulating Tumour Cell Isolation" who is supervised by Yi Sui and ... [more]

ILF 2020 in full swing

Another Hugely Successful ILF Completed

The School of Engineering and Materials Science hosted another successful Industrial Liaison Forum (ILF) on Wednesday 26th February 2020 which attracted 85 visitors during the day. The focus was on our Taught Programme Student Projects with more than 100 of our students having the opportunity to discuss their projects with each other, QMUL ... [more]

The MEng group being congratulated by Dr Adrian Briggs (on the right)

Robot Hand Team Wins Top Prize at ILF

A team of 4th year MEng students Jamie SENGUN, Ahmed DEIRI, Talha TAILOR, Kai PAGE & Mohammed KHAN who have been working on the "Soft 3D-printed Robotic Hand" project supervised by Dr Lorenzo Jamone & Dr Ketao Zhang won the best MEng group project prize at the Annual SEMS taught student Industrial ... [more]

Hacking Hearts illustration by Libby Morrell who followed the workshop with her amazing line drawings

First outcome of our 'Hacking Hearts' art and science outreach collaboration with Central Saint Martins released online

Central Saint Martins published a first story about the outcome or our art and science collaboration. This fast-paced project saw postgraduate students from across disciplines hack the research of our inaugural Scientists in Residence over the course of a week. You can read here: https://www.arts.ac.uk/colleges/... [more]

Professor Hazel Screen

Join us for Professor Hazel Screen's Inaugural Lecture

We are delighted to announce that Professor Hazel Screen's Inaugural Lecture will be taking place on Thursday 19 March. Hazel's research spans from the nano-scale to whole body mechanics, where she utilises a bioengineering approach to explore the relationships between tissue health and disease, and the surrounding mechanical environment. Hazel will ... [more]

Knee replacement implant (https://bonesmart.org/knee/choosing-a-knee-implant-prosthesis/)
Image credit: Conformis

New paper on the anti-inflammatory effects of low levels of cobalt ions

Cobalt ions from some orthopaedic implants induce a dose-dependent cytotoxic and pro-inflammatory response. However, this new paper from Prof Knight and Prof Shelton's groups shows that low levels of cobalt are in fact beneficial and block pro-inflammatory signalling in cartilage. The authors showed that sub-toxic levels of cobalt (50uM) prevented ... [more]

The Organ-on-a-chip team, L to R: Martin, Julia, Sarah, Aysha, Angel, Stephen, Matthew, Luana, Paul, Mina, Elisabete, Ashley, Chrysanthi, Stefaan, Clare & Natt

The Organ-on-a-Chip Shop – a Science Museum highlight!

On 29 January, Organ-on-a-Chip Technologies Network scientists and engineers swapped their lab coats for aprons, to run the Organ on a Chip shop at the hugely popular Science Museum Lates in London. This Lates night celebrated the launch of the Museum’s new Medicine Galleries and attracted over 4,000 visitors. Promoted as ... [more]

Prof Dan Bader

Dan Bader Gives His Valedictory Lecture in Technical University of Eindhoven

During his time as Professor of Medical Engineering at Queen Mary University of London, Prof Bader was also a part-time visiting professor in the Technical University of Eindhoven (Tu/E). There he worked closely with Prof Cees Oomens in the area of pressure ulcers as well as continuing his work ... [more]

We're hiring!

We are currently hiring, with both a PDRA and PhD studentship in the organ-on-a-chip field. If you're interested in building new musculoskeletal in vitro models with us, we'd be delighted to hear from you! PhD Studentship: The interfascicular matrix niche – novel approaches to identify the aetiology of tendinopathy: https://www.... [more]

Emulate's organs-on-chips technology. Credit: Emulate

Queen Mary opens Organs-on-Chips Centre for advancements in medical research and drug development

A new research centre which aims to revolutionise medical research and drug development using microengineered Organs-on-Chips has opened at Queen Mary University of London. Organs-on-Chips contain tiny hollow channels lined by living human cells that recreate the microenvironment experienced by cells within the human body.  As miniaturised living systems with ... [more]

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Profs Knight and Screen interviewed for report on organ-on-a-chip

Profs Knight and Screen were recently interviewed for a news article on organ-on-a-chip which has just been published in the magazine Engineering & Technology. The article explored the potential of organ-on-a-chip technology for testing the safety and efficacy of new pharmaceuticals and the impact on conventional animal testing. [more]

Mechanobiology : From Molecular Sensing to Disease

Clare Thompson and Megan McFie publish chapter in new mechanobiology book.

Clare Thompson and Megan Mcfie have helped write a chapter on primary cilia mechanobiology in an excellent new book entitled Mechanobiology : From Molecular Sensing to Disease. The chapter reviews the role of primary cilia in mechanosignalling in a variety of tissues and the effect of mechanical forces on cilia structure ... [more]

Liz presents plans for 2020

Planning Meeting for World Biomaterials Congress

On 3 and 4 December the Executive Committee, Liz Tanner, Lucy Di Silvio King's and Nicholas Dunne Dublin City University for the 2020 World Biomaterials Congress meet in Glasgow. We have received over 2,800 abstracts with spaces for 1,200 Oral presentations so have offered the remainder Poster Presentations. The e-mails should be sent before Christmas ... [more]

Visitors can see the Organ-on-a-Chip Technologies Network

Organ-on-a-Chip on show at Science Museum Lates

Science Museum Lates: Medicine, 18.45 - 22.00, Wednesday 29 January 2020 (over -18s only) Organ on a Chip Shop - a Lates highlight! Organ-on a-Chip Technologies Network members from across the UK will be running the shop at this hugely popular event. Based on the concept of a fish & chip takeaway, this 'make ... [more]

Megan presenting at the International Conference on Cilia, Flagella and Centrosomes in Paris

Knight group presentations at the International Cilia & Centrosomes Conference

Several members of the Knight group have been at the excellent International Conference on Cilia, Flagella and Centrosomes organised by the French and UK Cilia Networks. On the first day Megan gave a fantastic presentation on her PhD project screening >1700 compounds for effects on primary cilia structure as part of ... [more]

Megan (left) and Hudair (2nd from right) collecting their poster prizes

PhD poster prizes to Megan and Hudair

Congratulations to Megan and Hudair who both won prizes for their PhD research posters at the Industrial Liaison Forum organised by the School of Engineering and Materials Science. Both Megan and Hudair are part of Knight’s research group. Megan’s PhD is co-supervised by Dr Cleo Bishop at the ... [more]

Networking Session in Action

Industrial Liaison Forum is a Tremendous Success

The biannual Industrial Liaison Forum was held on Wednesday November 20th November in the Octagon. The event was well attended with over eighty industrialists from more than sixty organisations attending. The event was broken up into four parts, starting in the morning with the PhD research poster exhibition, followed by ... [more]

From left to right Valeriia Kudriavtceva, Megan McFie, Julia Strudwick from Polymax, Hudair Samad  and Prof Martin Knight

Award Winning Research Students in SEMS

At the SEMS annual research led Industrial Liaison Forum, there was a research showcase from 80 of our current PhD students. The panel of judges this year were made up a wide range of academics from each division. They decided after a careful deliberation to award the following prizes: 1st Prize: ... [more]

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SEMS at 'Hacking Hearts' at Central Saint Martins

We're excited to be participating in 'Hacking Hearts' at Central St Martins in London. The event is a ‘Hackathon’, a week-long project re-imagining heart research artistically by Central St Martins Arts Students. Dr Thomas Iskratsch, with help of his group, will be Scientist in Residence. The workshop finishes with a ... [more]

AC photocurrent imaging at an epitaxial layer of InGaN/GaN on sapphire was shown to be sensitive to the impedance of a polymer dot and the negative surface charge of an isolated cell. AC photocurrents were excited with a focused, intensity-modulated 405 nm laser and measured with a lock-in amplifier. Images were obtained by measuring the photocurrent while moving the electrochemical cell with respect to the laser beam using an XYZ positioning system.

InGaN suitable as a substrate for photoelectrochemical imaging in life sciences

Bo's paper on the use of InGaN as the semiconductor substrate for AC photoelectrochemical imaging has been accepted by Sensors. AC photocurrent imaging at metal oxide semiconductors auch as ITO and ZnO nanorods has been shown to suitable for bioimaging applications such as the measurement of the negative surface charge ... [more]

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Lei Su nominated as committee member of IEEE Photonics Conference Council

IEEE (Institute of Electrical and Electronics Engineers) Conference Council regularly review the Society's meetings portfolio, including major conferences in the field of Photonics. The Conference Council is also responsible for reviewing and approving requests for technical co-sponsorship, Chairs and Representatives for selected conferences, and location and venue selections for the ... [more]

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Professor Wen Wang elected FREng

Professor Wen Wang has been elected a Fellow of the Royal Academy of Engineering today. This is as: Wen Wang is distinguished for his insightful achievements in cardiovascular bioengineering, specifically in biofluid mechanics related to the molecular lining of blood vessels and the transport of fluid and solutes across the ... [more]

Super resolution microscopy images of polycystin-2 and primary cilia

New research published in Nature Communications, reveals how the location of the protein Polycystin-2 (PC2) on primary cilia regulates Polycystic Kidney Disease.

Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a common yet devastating disease. It is a heritable disorder characterised by development of kidney cysts which slowly overtake the kidney’s structure, destroying its function, and often resulting complete kidney failure by the of age 60. ADPKD affects as many as 1 in 400 people ... [more]

Video.

Bioengineers and Cancer Biologists develop a complex in vitro model of the human tumour - new Ideaslab video

Bioengineers are trying to grow human organs, so could growing human tumours help us to understand the microenvironment in which they spread – and how the immune system might be persuaded to attack them? Frances Balkwill explains in this new Ideaslab video for the World Economic Forum how our research at ... [more]

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Liz Tanner gives Lecture in Sichuan University

While in China to present the 11th World Biomaterials Congress 2020 to the Chinese Society for Biomaterials, Liz Tanner also visited Professor Zhang Xingdong (former Research Visitor to the Department of Materials) at Sichuan University and gave a lecture entitled "Composite Materials for Bone Augmentation". [more]

Dr Chowdhury present a quote from Professor Peter McOwan

Talk about saving babies' lives inspires young people to become bioengineers

Queen Mary researcher Dr Tina Chowdhury gave an inspiring talk to young people about saving babies’ lives at the eighth St Paul’s Way Trust Science Summer School chaired by Professor Brian Cox (OBE) and Lord Andrew Mason (OBE). Dr Chowdhury’s research is investigating ways to repair holes in ... [more]

Biomin toothpaste developed by Robert Hill and staff at Queen Mary University of London

Queen Mary Dental Professor becomes first British winner of prestigeous Varshneya Award

Professor Hill, the first British scientist to win this award, was presented with his prize at the 25th International Glass Congress in Boston. The Award was made by the American Ceramic Society.  An expert on fluorine containing glasses and glass-ceramics, Professor Hill initially worked on high fluorine content glasses used ... [more]

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Mexican government presents Queen Mary academic with prestigious award

Professor Teresa Alonso-Rasgado, Queen Mary’s Dean for Global Engagement in the Faculty of Science and Engineering, has been awarded the highest distinction possible for her academic excellence in Mexico. The Lazaro Cardenas Medal for academic excellence was presented to Professor Alonso-Rasgado by the Secretary of Education, Esteban Moctezuma Barragá... [more]

https://www.oatechnetwork.org/

Funding awarded for mechanobiology research into osteoarthritis

Queen Mary Researchers have been awarded funding for three separate biomechanics and mechanobiology pump priming projects. Professors Hazel Screen and David Lee of the School of Engineering and Materials Science were awarded funding from the OAtech+ Network to develop projects relating to mechanobiology aimed at targeting the chronic, degenerative disease ... [more]

Protease sensitive hydrogels based on peptide cross-linked poly(2-oxazoline) co-polymer

ACS Biomacromolecules paper on peptide cross-linked poly(2-oxazoline) as a sensor material for the detection of proteases accepted

Norlaily Ahamad's paper on peptide cross-linked poly(2-oxazoline) as a sensor material for the detection of proteases has been accepted by Biomacromolecules. Increased levels of active proteases are frequently associated with inflammatory conditions, and there is increasing demand for point of care devices for monitoring inflammation. Norlaily cross-linked a poly(2... [more]

Muchun answering questions at the end of her talk.

Muchun and Bo present at the XXV. International Symposium on Bioelectrochemistry and Bioenergetics in Limerick

Muchun Zhong's and Bo Zhou's presentations were well received by the Bioelectrochemistry community. Muchun presented her work on light-addressable potentiometric sensors for the detection of zinc, and Bo talked about photoelectrochemical imaging with iron oxide nanorods. [more]

Microvascularised organ-on-chip platform developed in the Gautrot Lab

Funding awarded to develop kidney-on-a-chip for animal free drug testing

A Queen Mary researcher has been awarded funding to develop artificial kidneys, known as kidney-on-a-chip, to avoid testing drugs on animals. Dr Julien Gautrot, from the School of Engineering and Materials Science, was awarded the £50,000 grant from The National Centre for the Replacement, Refinement and Reduction of Animals in Research (... [more]

A close-up of Dr Hing's stamp

Synthetic bone graft research gets stamp of approval

The pioneering work of a Queen Mary researcher has been celebrated with a stamp as part of a new series launched by Royal Mail. The six stamp set, launched today, marks innovations in British engineering from the last 50 years including the development of a synthetic bone graft by Dr Karin ... [more]

Tina's podcast with The Naked Scientists https://www.bbc.co.uk/sounds/play/p077kmvf

New approach to repair fetal membranes may prevent birth complications

Researchers from Queen Mary University of London and University College London have developed a new approach to repair defects in fetal membranes which could prevent life-long medical conditions and disabilities associated with preterm birth. The integrity of the fetal membranes that surrounds the baby in the womb during pregnancy is ... [more]

The negative surface charge of the cell reduces the amount of hydroxide ions diffusing to the sensor surface thereby decreasing the local photocurrent.

First report of cell surface charge mapping with a photoelectrochemical imaging system appears in Analytical Chemistry

Fan's and Bo's paper on the photoelectrochemical imaging of cell surface charges has been been accepted by Analytical Chemistry. Photoanodic currents at indium tin oxide (ITO) coated glass immersed in an electrolyte solution were shown to be sensitive to surface charge, pH and impedance. Our laser scanning setup allows photoelectrochemical ... [more]

https://www.organonachip.org.uk/

QM hosts Organ-on-a-chip Technologies Network meeting

Queen Mary hosted the UK Organ-on-a-chip Technologies Network for a special Learning and Collaborative Event. The network has over 450 members from 50+ academic institutions with over 50 partners from industry and other stake holders. The network event included a programme of research talks, discussion groups, industry demonstrations and special training sessions on ... [more]

Principle of the collagenase sensor

Norlaily's paper about collagenase sensor accepted

Our paper entitled 'Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(ethylene glycol) Hydrogel Films' written by Norlaily Ahmad, Burcu Colak, De-Wen Zhang, Michael Watkinson, Remzi Becer, Julien Gautrot and Steffi Krause has been published in Sensors 2019, 19(7), 1677; doi:10.3390/s19071677. Peptide cross-linked hydrogels were deposited on gold coated, piezoelectric ... [more]

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Exercise helps prevent cartilage damage caused by arthritis

Exercise helps to prevent the degradation of cartilage caused by osteoarthritis, according to a new study from Queen Mary University of London. The researchers show for the first time how mechanical forces experienced by cells in joints during exercise prevent cartilage degradation by suppressing the action of inflammatory molecules which ... [more]

https://www.bbc.co.uk/news/health-26617285

New research identifies optimal ventilation protocol for premature babies

A new paper from Prof Martin Knight's group examines the use of two different methods of providing mechanical ventilation to premature babies. The study led by Prof Anne Greenough and colleagues at King's College London, explores the effect of lung inflation volume on inflammation within the alveolar epithelial cells. The ... [more]

Rashna being congratulated by Dr Carolyn Small from Arconic, who is the Chair of the Materials Division Industrial Advisory Board.

3rd Year Project Poster Winners Announced

The Spring Industrial Liaison Forum played host to the 3rd year project student poster showcase. This year two winners were selected from the 300+ posters that were submitted. These were from Fatou CHANG for her poster on "Solar drier for agricultural food preservation in developing countries" who is supervised by Henri ... [more]

Moresche's Poster from the ILF

Moresche Bartley wins the best MSc student Poster Award

Moresche Bartley won the best MSc student prize at the 2019 Industrial Liaison Forum in SEMS for her poster called, "An in vitro study of myocyte and fibroblast co-culture response to degraded Mg alloy". Her project is being supervised by Prof. Liz Tanner [more]

The KYKLO team presenting their ideas at the ILF

Bike Design Team Wins Top Prize

A team of 4th year students: Arya LI, Bijoy DAS, Lydia DENTON & Yue MENG, who have been working on project to design a totally new road bike have won the top prize at the 2019 Industrial Liaison Forum. The students, supervised by Dr. Emiliano Bilotti and Dr. Han Zhang, presented their ... [more]

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Giant ‘nerve cell’ science education centre lands in London’s East End

‘Neuron Pod’ - a striking 23-metre long and 10-metre high free-standing structure – has opened its doors as an informal science learning centre at Queen Mary University of London’s Whitechapel campus. The launch was marked by a visit from children from Christ Church Primary School, Brick Lane, who took part ... [more]

Norlaily and Steffi after the viva

Norlaily Ahmad passes her PhD viva

Congratulations to Norlaily Ahmad who passed her PhD viva today. Norlaily's thesis title is "Biosensor for matrix metalloproteinase-9 (MMP-9) based on peptide-linked polymers". She was supervised by Steffi Krause and Remzi Becer and also had significant input from Julien Gautrot and Michael Watkinson. She presented her work at two international ... [more]

Women in STEM committee after the talk

Liz talks at Bristol University Women in STEM event

On Tuesday 5th February Liz Tanner gave a talk in the Senate House at Bristol University to the student's Women in STEM society as part of the Women in Conversation week of talks. A lively discussion afterwards with enthusiastic students from first year undergraduates to PhD students. [more]

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Feng Yang passes her PhD

Dr Feng Yang has successfully completed her corrections having defended her PhD thesis entitled "The Synergistic effect of Bone Graft Substitute Architecture and Mechanical Environment on hMSCs Responses in vitro". Her research on the development of 3D bioreactors to facilitate in vitro investigation of bone graft substitute bioactivity demonstrated the ... [more]

Nanopillar measurements of traction forces in absence of calponin-3.

New paper out from collaboration with the Lappalainen Lab!

This study shows a surprising role for Calponin-3 in controlling proper contractility of the stress fiber network. Will Hawkes collaborated with the Lappalainen lab and performed nanopillar assays to measure the traction forces that are associated with stress fibers. He could indeed detect higher forces in the knockout cells, as ... [more]

www.techrepublic.com - Soft Robotics

New video report on soft robotics for keyhole surgery

Breaking news on the EU robotics project STIFF-FLOP Research on soft robotics for keyhole surgery by Professor Althoefer, head of Advanced Robotics @ Queen Mary (ARQ) is highlighted in the new TechRepublic video on '5 things to know about soft robotics': 1. It doesn't mean pillows. 2. Search and rescue. 3. Medicine. (STIFF-FLOP features ... [more]

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Congratulations to Marta Godinho!

Marta Godinho has successfully completed her PhD viva today on a thesis entitled, "Investigating the role of elastin in tendon mechanics." She was supervised by Hazel Screen and Steve Greenwald with significant input from Chavaunne Thorpe, and was recipient of the Bonfield Scholarship though the Institute of Bioengineering. Marta has ... [more]

View of the altar waiting for the service to start

Liz Tanner attends Service to celebrate Year of Engineering

Liz Tanner was one of the 2000 guests at the ecumenical "National Service to Celebrate the Year of Engineering" held at Westminster Abbey. The address was given by Dame Anne Dowling OM DBDE FRS FREng President of the Royal Academy of Engineering. One of the lessons was read by Chris Grayling, ... [more]

President and Principal, Professor Colin Bailey with Honorary Professor Wang Jinsong, 2017

Queen Mary jointly hosts Sino-UK Symposium on advanced materials and structures

Nine academics from Queen Mary University of London presented at the Sino-UK Symposium attended by prestigious researchers and enterprises in thermoelectrics and advanced materials from China and the United Kingdom. The Sino-UK Symposium on Advanced Materials and Structures and UK-China Partnership Forum in Themoelectrics and Clean Energy took place in ... [more]

New article on our research in The Horse

we are excited to see an article in leading equine health magazine "The Horse" talking about our latest research findings and how we are working to understand and manage equine tendinopathy: https://thehorse.com/159937/tendon-problems-in-old-horses-what-goes-wrong/ [more]

Professor Althoefer

Professor Kaspar Althoefer interviewed about robot-assisted minimally invasive surgery.

Professor Kaspar Althoefer was interviewed about his research on soft robotics for robot-assisted minimally invasive surgery. "We wanted to take our inspiration from biology – so octopus tentacles were our inspiration....making something that was made of soft materials, to achieve more dexterous behaviour but also to increase patient safety." The ... [more]

Welcome to Antonios!

We are delighted to welcome Antonios Giannopoulos as a PDRA working on a Dunhill funded project, looking to investigate the early initiation of tendinopathy and why risk increases with ageing.

Professor Screen giving the opening keynote at this year's ISTS conference

Some of the group will be travelling to the 5th International Scientific Tendinopathy Symposium (ISTS) next week in Groningen. Prof Screen will give the opening keynote lecture about tendon ageing, where she will describe the ageing changes in the interfascicular matrix and how this may contribute to tendon injury risk [more]

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New Paper Accepted

Congratulations to Renjie (Jacky) Lui for the acceptance of his paper "Guided cell attachment via aligned electrospinning of glycopolymers" in MacroMolecular Bioscience. The work constitutes a large part of his PhD which he submitted earlier this month. Lui R, Becer CR, Screen HRC (2018) Guided cell attachment via aligned electrospinning of ... [more]

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Liz Tanner Returns to QMUL

After just over 11 years at the University of Glasgow, Liz Tanner has returned to School of Engineering and Materials Science to become the first Bonfield Professor of Biomedical Materials. Liz's first job was as a post doc in Bill Bonfield's Biomaterials Group, before the foundation of the IRC in Biomedical ... [more]

Launch event group photo on Graduate Centre terrace at QMUL

Organ-on-a-Chip Network launch a great success

The UK Organ-on-a-Chip Network official launch took place last week. On the 6th of September there was a conference day, held in conjunction with the BioMedEng18 Conference, taking place at Imperial College London and followed by a launch day at Queen Mary’s Graduate Centre on Friday the 7th. This ... [more]

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Scientists design material that can store energy like an eagle’s grip

What do a flea and an eagle have in common? They can store energy in their feet without having to continuously contract their muscles to then jump high or hold on to prey. Now scientists at Queen Mary University of London and University of Cambridge have created materials that can ... [more]

Confocal microscopy images showing tendon cells with primary cilia. Top image is a cell within tendon tissue. Bottom image is an isolated tendon cell growing in vitro. Nucleus labelled in blue, primary cilia labelled with acetylated alpha tubulin (red)

Mechanical regulation of primary cilia in tendon cells suggests a novel feedback mechanism controlling tendon health and mechanosensitivity.

New research from Prof Martin Knight and Prof Hazel Screen's group at Queen Mary University of London reveals a novel feedback mechanism regulating tendon health and homeostasis during mechanical loading. The study published in Scientific Reports investigates primary cilia in tendon cells subject to physiological and pathological mechanical loading. Primary ... [more]

A close-up of the enamel-like material

Scientists develop material that could regenerate dental enamel

Researchers at Queen Mary University of London have developed a new way to grow mineralised materials which could regenerate hard tissues such as dental enamel and bone. Enamel, located on the outer part of our teeth, is the hardest tissue in the body and enables our teeth to function for ... [more]

The instrument will combine two electrochemical imaging techniques which measure cell responses on the top and bottom layer

Queen Mary awarded funding to build instrument which will revolutionise monitoring of cellular processes

Queen Mary University of London has been awarded funding to lead a joint project to build an instrument which will revolutionise the monitoring of cellular processes in tissues that line organs. The grant from the Engineering and Physical Sciences Research Council (EPSRC) has a total value of £823,329 over three years, ... [more]

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Technology network awarded funding to capture musculoskeletal degeneration

Queen Mary University of London - as part of a group of universities, hospitals and research centres - has been awarded funding to create a network seeking to develop new, high energy imaging methods to capture the dynamic biochemical and biophysical processes in biological samples. The human body is highly ... [more]

An Organ-on-a-Chip device (Emulate, Inc.)

Queen Mary Awarded Funding to Establish Organ-on-a-Chip UK Network

Queen Mary University of London has been awarded funding to lead a UK network in the development of ‘Organ-on-a-chip’ devices. The network will be part of a major new Research Councils UK (RCUK) funding venture, Technology Touching Life [1], which aims to foster interdisciplinary research into innovative technology in the health ... [more]

Dan Rowson

Dan Rowson passes his PhD on the effect of mechanical loading on tendon cells

Congratulations to Dan Rowson who passed his PhD viva. Dan's PhD thesis investigated the effect of mechanical stimulation on tendon cells in order to better understand the process of tendon injury. In particular, Dan investigated the effect of mechanical forces on tiny hair-like cellular structures structures, known as primary cilia. ... [more]

Prof Screen

New Dunhill Medical Trust grant awarded to Prof Hazel Screen to investigate the development of tendon injury with ageing.

Professor Hazel Screen has been awarded a Dunhill Medical Trust grant of £190,000, to investigate the causes of age-related tendon injury. Tendon injuries are extremely painful and highly debilitating, and become increasingly common as we age, where they can dramatically affect quality-of-life. Developing treatments is of the utmost importance, but scientists ... [more]

Dr Tina Chowdhury

Storytelling project for engineers and young east Londoners wins funding

A Queen Mary University of London project which aims to give engineers the skills to create digital stories about how their work can improve the world has received funding from the Ingenious Awards. ‘Engineer the Story’ will bring together engineers to work alongside disadvantaged young people from east London who ... [more]

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New animation from the British Heart Foundation shows how SEMS research into tiny tech is helping to treat heart failure

Heart failure affects an estimated 920,000 people in the UK. It means that your heart can't pump blood as well as it should do. One of the most common causes of heart failure is a heart attack. After a heart attack the damaged heart muscle can become stiff. This means your ... [more]

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Institute of Mechanical Engineers confirms accreditation of SEMS programmes

The Institute of Mechanical Engineers (IMechE) has confirmed the accreditation details for our programmes following their re-accreditation visit to SEMS in November. Students completing an IMechE accredited degree are deemed to have met part or all of the academic requirements for registration as a Chartered or Incorporated Engineer and are ... [more]

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Exciting New Paper on the Tumour Microenvironment

A new paper published in the journal Cancer Discovery, by Prof Martin Knight and colleagues describes, for the first time, an evolving human metastatic microenvironment. The work led by Prof Fran Balkwill measures gene expression, matrisome proteomics, cytokine and chemokine levels, cellularity, extracellular matrix organization, and relates this to changes ... [more]

Jake is being congratulated by Wen Wang and Lorenzo Botto

Best 3rd Year Project Student Awards Awarded at the Spring Industrial Liaison Forum

At the Spring Industrial Liaison Forum (ILF) every 3rd year project student was invited to submit a poster on their research. The best 50 posters were displayed to the visitors and the students competed for the best 3rd Year Project Prize. The judges deliberated at length and decided to split the ... [more]

Prof Wen Wang (Head of School) congratulates Philomena on her project poster competition win.

Best MSc Student Project Poster

At the Spring Industrial Liaison Forum (ILF) all the MSc students were invited to submit a poster on their research topics. The best posters were invited to compete for the DePuy Synthes' MSc student Prize. The standard was once again very high this year but after careful deliberations the award ... [more]

Marie Currie Actions H2020

Marie Curie Fellowship Award for Dr Luming Zhao

Congratulations to Dr Luming Zhao, who has been awarded a two-year H2020 Marie Curie Fellowship (€200k), supervised by Dr Lei Su, Prof Martin Knight and Dr Manoj Ramachandran. He will develop novel compact optical fibre lasers for clinical imaging and laser surgery. [more]

Best MEng  group from the 2018 ILF

Best MEng Group in SEMS Award

At the Spring Industrial Liaison Forum (ILF) event all the 4th year MEng group project students in SEMS had the opportunity to present their projects and compete for the DePuy Synthes Group Project Prize. The standard was once again very high this year but after careful deliberations the award for ... [more]

Students talking to an alumni visitor about career options after QMUL

SEMS Industrial Liaison Forum is a Great Success

The Spring SEMS Industrial Liaison Forum was a very popular event again this year. In the morning the annual taught student showcase took place in the Octagon which was followed in the afternoon by a wide range of alumni lead panel and networking sessions. There was also an Industrial Advisory ... [more]

Professor Gleb Sukhorukov

Professor Gleb Sukhorukov reaches an h-index of 95

Congratulations to Professor Gleb Sukhorukov whose h-index has recently reached 95, as per Google Scholar. The h-index is a numerical indicator of how productive and influential a researcher is. Gleb is author and co-author of more than 300 papers whose impact is reflected in more than 30 000 citations of his works. He pioneered ... [more]

Cells can ‘walk’ on liquids a bit like the way geckos stick to other surfaces using shear forces

Cells ‘walk’ on liquids a bit like geckos

Researchers at Queen Mary University of London have discovered that cells can ‘walk’ on liquids a bit like the way geckos stick to other surfaces. Cells are typically grown on solid materials, such as tissue culture plastic, degradable polymers and bioceramics. It is thought that the strong mechanical properties of ... [more]

Cells spreading on the outside of a scaffold

New printing technique uses cells and molecules to recreate biological structures

Researchers from Queen Mary University of London have developed a printing technique using cells and molecules normally found in natural tissues to create constructs that resemble biological structures. These structures are embedded in an ink which is similar to their native environment and opens the possibility to make them behave ... [more]

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Fake a knee at the Science Museum

When we loose cartilage tissue in the knee joint and suffer from knee pain, the joint function is impaired and the patient may need a total knee replacement surgery. The procedure involves removal of the damaged and diseased joint and replacement with an artificial joint. Most patients who undergo knee ... [more]

New research grant on bone cancer mechanobiology and primary cilia funded by the EU.

New grant on mechanobiology of bone tumours

Dr Stefaan Verbruggen has recently joined the bioengineering group at Queen Mary on a Marie Sklodowska-Curie Actions Individual Fellowship. Stefaan is working in Prof Martin Knight's research group investigating the role of mechanical forces in bone cancer and the involvement of primary cilia. Stefaan's project is entitled 'META-DORM: Mechanobiology of ... [more]

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New Published Research: Cells in the heart sense stiffness by measuring contraction forces and resting tension simultaneously

Researchers from Queen Mary University of London have identified a new mechanism in which adhesive structures within the cells of the heart sense stiffness through muscle contractions and resting tension at the same time. The study, published in Developmental Cell, further shows that the resting tension in the heart cells ... [more]

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Cells in the heart sense stiffness by measuring contraction forces and resting tension simultaneously

Researchers from Queen Mary University of London have identified a new mechanism in which adhesive structures within the cells of the heart sense stiffness through muscle contractions and resting tension at the same time. The study, published in Developmental Cell, further shows that the resting tension in the heart cells ... [more]

Fluorescently-labeled protein patterns within different types of 3D hydrogels

New molecular printing technology could recreate complex chemical environments that resemble the human body

New patterning technology which could open opportunities to recreate complex biological environments has been developed by researchers at Queen Mary University of London (QMUL). '3DEAL' is a simple and inexpensive fabrication technique able to generate complex molecular patterns within soft matter, such as hydrogels, with microscale resolution and up ... [more]

Dr Wei Ding

PhD success for Dr Wei Ding

Congratulations to Dr Wei Ding who passed his PhD viva on the 31st of October 2017. Wei worked with Professor Wen Wang and Dr Mario Orsi on molecular dynamic simulation of lipid bilayer membranes. He was jointly funded by QMUL and the China Scholarship Council. During his PhD study, Wei has ... [more]

Super resolution microscopy images of chondrocyte primary cilia showing the reduction in cilia length in an expanded cell (right) compared to a freshly isolated cell (left). The scale bars are 2 microns.

Study reveals how manipulation of primary cilia may improve cartilage tissue engineering

A new paper from Prof Knight's group shows how expansion of cartilage cells for tissue engineering disrupts primary cilia expression inhibiting associated cellular signalling. Primary cilia are specialised, hair-like structures found singly in the majority of cell types where they coordinate a variety of cell processes important for tissue development, ... [more]

The findings of this research study may help explain why cartilage breaks down with ageing or arthritis.

Research paper identifies the secret life of collagen

Dr Gupta and Prof Knight have just published exciting results which cast light on how cartilage is able to withstand the demanding mechanical environment of the joint and may eventually help to explain why cartilage breaks down with ageing or arthritis. Collagen changes its crystallinity in response to physical forces, ... [more]

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Repair of fetal membranes could reduce preterm births

Life-long medical conditions and disabilities associated with preterm birth could be prevented with a new bioengineering approach led by researchers at Queen Mary University of London (QMUL). Bioengineers from SEMS working together with clinical practitioners have potentially found a way to reduce preterm births and prevent early deaths of young ... [more]

David Barrett

PhD student David Barrett wins 2016 Malcolm Ferguson-Smith Young Investigator award

Congratulations to our PhD student David Barrett, who has won the prestigious 2016 Malcolm Ferguson-Smith Young Investigator Award for his article published in the October 2016 issue of the Prenatal Diagnosis journal. The title of David's article is “Connexin 43 is overexpressed in human fetal membrane defects after fetoscopic surgery”. The Young Investigator ... [more]

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Research to heal fetal membranes receives funding from Great Ormond Street and Sparks Charity.

Dr Tina Chowdhury has been awarded a project grant by GOSH and Sparks charity (£148, 862). The project will develop a novel therapy to heal fetal membrane defects in the womb with Anna David (fetal medicine professor, UCL), Alvaro Mata (nanotechnology professor, SEMS), Jan Deprest (fetal surgeon/professor, Leuven), Dan Bader (biomechanics ... [more]

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Virtual Lab project wins prestigious higher education award

The Virtual Lab, a platform that allows students to learn lab skills in bioengineering and the life sciences, has won the Gold Award at the Life Sciences category. The Awards celebrate innovative higher education pedagogies which enhance learning and employability across the globe. The Virtual Lab uses the latest games ... [more]

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The Virtual Lab shortlisted for prestigious higher education award

The Virtual Lab, a platform that allows students to learn lab skills in bioengineering and the life sciences has been nominated for the e-Learning Innovation category in the Reimagine Education Awards 2016. Dr Tina Chowdhury, Senior Lecturer in Regenerative Medicine at the School of Engineering and Materials Science, said: “I’m ... [more]

The children make biomaterials with James Taylor. Examples include worms and beans from seaweed and sugar that can easily change shape.

Opening young minds to bioengineering

A pioneering scheme called The Bioengineering Experience, developed for school children to explore advances in science, engineering and materials hosted a group of ten-year olds from St Joseph’s in the Park returning for their second visit to Queen Mary University of London (QMUL). Led by Dr Tina Chowdhury from ... [more]

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New generation of synthetic bone grafts created

Scientists led by Queen Mary University of London (QMUL) have developed a new type of synthetic bone graft that boosts the body’s own ability to regenerate bone tissue and could produce better outcomes for patients. The research, which is published in the Journal of Materials Science: Materials in Medicine ... [more]

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The Bioengineering Experience 2015

Dr Tina Chowdhury's new fillm called "The Bioengineering Experience" can be seen here:

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The bioengineering experience 2015

Children aged 10 from St Joseph’s in the Park visited the Institute of Bioengineering and experienced real, hands on lab activities at the School of Engineering and Materials Science. The project funded by the Center for Public Engagement, was a fantastic event encouraging young people to experience bioengineering first hand. ... [more]

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Can a protein help to protect osteoarthritic joints? Dr Tina Chowdhury and team investigate

For more information on this story, please see the interview on Youtube with Dr Nick Peake, one of the researchers involved in the project.