SEMS Research Seminars
Institute of Bioengineering Seminars
| Wed 20 Feb 2019 12:00 - 13:00 | 'A super-resolved look at synthetic nanomaterials' |  |
| Wed 27 Feb 2019 15:00 - 16:00 | Professor Dustin was trained in Tim Springer’s lab at Harvard Medical School and Stuart Kornfeld’s lab at Washington University in St Louis. He started his Lab at Washington University in St Louis using supported lipids bilayers to study dynamics of the immunological synapse. Work at NYU School of Medicine focused on in vivo analysis of immune cell function in multiple tissues with a focus on tolerance, cancer and infection models. In Oxford he has focused on the immune T cell immunological synapse and the formation of nanoscale extracellular vesicles. This is a unique form of communication that allows the T cell to send out particles with a combination of antigen specificity and effector function. The system is also amenable to analysis by nanofabrication methods. In work started at NYU and continued at Oxford. Professor Dustin has used 3D nano position of T cell receptor ligands to determine the role of phosphatase exclusion in control of T cell responses. | |
| Wed 20 Mar 2019 15:00 - 16:00 | Abstract: | |
| Wed 3 Apr 2019 15:00 - 16:00 | By developing and employing high-resolution live-cell imaging techniques, Dr Draviam has significantly contributed to the molecular understanding of how microtubule-mediated forces ensure proper cell division. Microtubules capture chromosomes and pull them apart into two sets; simultaneously, microtubules rotate the mitotic spindle to dictate the plane of division. The group demonstrated that human chromosomes are captured along microtubule-walls and then brought to microtubule-ends, without detachment, and termed this the end-on conversion process. The group has identified several proteins important for the multi-step end-on conversion process, and genome stability. Searching for similar microtubule wall interaction at other subcellular spaces led to the discovery of MARK2 as a microtubule length regulator needed to push the spindle to the cell's center for normal rotation. While pulling forces are known to be important for spindle rotation, the Draviam group revealed the importance of spindle pushing forces. These, molecular findings on microtubule-mediated force generation has implications for cancer cell biology and epithelial tissue engineering. | |
| Wed 1 May 2019 15:00 - 16:00 | Light-based technologies such as florescence, multispectral and polarisation resolved imaging are opening up the possibility for in vivo tissue characterisation and image-guided surgery using live information feedback. | |
Materials Reseach Institute Seminars
| Wed 20 Feb 2019 09:00 - 17:00 | | |
| Wed 27 Feb 2019 09:00 - 17:00 | | |
| Thu 7 Mar 2019 17:00 - 19:30 | Beñat Gurrutxaga-Lerma (University of Cambridge), TYC Soiree: “Structural Materials” | |
| Wed 10 Apr 2019 15:00 - 16:00 | | |
| Thu 2 May 2019 17:00 - 19:30 | |