£13,765,664
Centre for Bioengineering
Funded Research Projects
The following are current funded research projects taking place within the research centre:
Mapping populations to patients: designing optimal ablation therapy for atrial fibrillation through simulation and deep learning of digital twinPrincipal Investigator: Caroline RONEY Funding source: UKRI Medical Research Council Start: 01-11-2022 / End: 31-10-2026 Amount: £1,224,259 We will combine biophysical simulation and deep learning methods with a longitudinal digital twin approach to optimise risk prediction and choice of therapy for atrial fibrillation. We aim to move predictions from the acute response to the long-term response; from the average patient to an individual patient; from standard treatments to any treatment approach; from small patient cohorts to large virtual trials; and from long simulation times to short clinical timescales. |
Talin dependent mechanical imprinting as driver for cardiac disease progressionPrincipal Investigator: Thomas ISKRATSCH Funding source: BHF British Heart Foundation Start: 01-09-2023 / End: 31-08-2026 Amount: £718,167 |
Engineered Recombinant Strategies to Organogel Design for Food Product FormulationsPrincipal Investigator: Julien GAUTROT Funding source: Motif Food Works Inc Start: 01-09-2022 / End: 31-08-2026 Amount: £32,500 |
Tomo-SAXS: Imaging full-field molecular-to-macroscale biophysics of fibrous tissuesPrincipal Investigator: Himadri GUPTA Funding source: EPSRC Engineering and Physical Sciences Research Council Start: 01-01-2021 / End: 25-10-2025 Amount: £451,556 This project will combine X-ray phase-contrast tomographic imaging and small-angle X-ray scattering to develop a path-breaking new technique - TomoSAXS – for the multiscale biophysics of tissues. We will develop advanced reconstruction algorithms to generate full-field 3D images of molecular to macroscale soft tissue structure, using the intervertebral disc as a prototypical organ. |
G1F1 Application of a new high throughput platform for validation of mechanosensitive miRNAPrincipal Investigator: Rob KRAMS Co-investigator(s): Gleb SUKHORUKOV Funding source: BHF British Heart Foundation Start: 03-10-2022 / End: 02-10-2025 Amount: £117,986 |
Designing motile and chemotactic protocells and exploit cellular collective behavioursPrincipal Investigator: Claudia CONTINI Funding source: BBSRC Biotechnology and Biological Sciences Research Council Start: 02-01-2023 / End: 30-09-2025 Amount: £371,059 |
Human synovium-cartilage organ-chip for personalised surgical screeningPrincipal Investigator: Timothy HOPKINS Co-investigator(s): Martin KNIGHT Funding source: AR-UK Versus Arthritis Start: 01-04-2022 / End: 31-03-2025 Amount: £311,203 Scientists at Queen Mary University of London are creating a human knee-on-a-chip device to understand how arthritis develops in individual patients and to test treatment strategies. The so-called organ-on-a-chip will consist of living cells taken from the knee joints of patients with osteoarthritis. The cells from patient’s cartilage and other tissues within the knee, will be grown within the laboratory in a carefully bioengineering organ-on-a-chip and used to understand which patients respond well to treatment. This will ultimately allow clinicians to optimise therapies to individual patients in an approach known as precision medicine or personalised medicine. |
AI-guided Prostate BiopsyPrincipal Investigator: Zion TSE Funding source: AMS Academy of Medical Sciences Start: 31-03-2023 / End: 30-03-2025 Amount: £497,258 The AMS Professorship will enable Prof. Tse's team to clinically validate next-generation interventional technology for affordable image fusion with a small footprint and translate it to clinical practice. Zion’s planned project, a collaboration between his lab and Addenbrooke’s Hospital, will aim to improve freehand transperineal prostate cancer biopsy by developing an integrated 3D MRI-US image fusion system built upon state-of-the-art AI techniques. This system will help clinicians precisely navigate needles to lesions in the prostate for more effective diagnosis and treatment. |
MRI-guided Focal Laser Ablation for Prostate Cancer TreatmentPrincipal Investigator: Zion TSE Funding source: Start: 01-03-2020 / End: 28-02-2025 Prostate cancer is one of the most common malignancies in males and has now become the second leading cause of cancer mortality. Prostate cancer diagnosis has increased from 3.9% to 8.2% of the population in the past decade. Approximately 52,300 new cases of prostate cancer are diagnosed in the United Kingdom every year, which is more than 140 every day. In this study, a robotic platform used for MRI-guided prostate therapy, including both biopsy and ablation, will be developed and validated. Compared with all the listed MR-safe robot platforms, the presented design will have a compact size, allowing it to be placed inside the scanner quickly. Moreover, the use of pneumatic stepper actuators will reduce the affection of EMI generated by piezoelectric motors and all the other parts are made of plastic, making the whole system to be MR safe. |
Wearable sensor for vascular access home monitoringPrincipal Investigator: Lei SU Co-investigator(s): Haixue YAN Funding source: Kidney Research UK Start: 01-01-2023 / End: 31-12-2024 Amount: £30,000 Kidney Research UK Dialysis Competition |
Remote Vital Signs Monitor for Infection Control or Fall PreventionPrincipal Investigator: Zion TSE Funding source: Start: 01-11-2022 / End: 31-10-2024 Recent miniaturisation developments in electronic systems have resulted in a wearable technology boom. This in turn has led to an increase in both vital sign monitoring and research into non-invasive and continuous monitoring methods. Various studies have shown the feasibility of using seismocardiogram (SCG) in heart rate variation (HRV) analysis and diagnostic purposes. This study aims to build upon the research done on SCG through development of a novel, real time Android based system which can calculate the heart rate and the respiratory rate of patients. |
Engineering Circadian Biology into Human Induced Pluripotent Stem Cell Organ-on-a-Chip modelsPrincipal Investigator: David LEE Funding source: BBSRC Biotechnology and Biological Sciences Research Council Start: 01-02-2022 / End: 31-08-2024 Amount: £201,874 |
British Heart Foundation – 4 year Doctoral Training ProgrammePrincipal Investigator: Amrita Ahluwalia Co-investigator(s): David LEE Funding source: British Heart Foundation Start: 01-09-2017 / End: 31-08-2024 Amount: £2,300,000 Led by Professors Amrita Ahluwalia and Tim Warner and involving 23 named researchers, the BHF DTP Programme provides cohort training leading to a PhD in cardiovascular research. |
Dual targeting and triggered delivery of biomacromolecules from layer-by-layer decorated gas filledPrincipal Investigator: Gleb SUKHORUKOV Funding source: Ionis Pharmaceuticals, Inc. Start: 01-07-2022 / End: 01-07-2024 Amount: £292,164 |
Organ-on-a-chip model of breast cancer bone metastasesPrincipal Investigator: Martin KNIGHT Co-investigator(s): Funding source: CR-UK Cancer Research UK Start: 01-01-2021 / End: 31-05-2024 Amount: £268,711 Background A common site for invasive ductal carcinomas (IDC) metastasis is bone, affecting about 70% of patients. Once metastasis to bone has occurred the five-year survival rate drops from 99% to 29%. How breast cancer metastasises to bone is poorly understood, partly because of the lack of appropriate models. Organ-on-a-chip technology is … |
KTP with Lucideon: Cell testing to assist development of novel biomaterialsPrincipal Investigator: Karin HING Co-investigator(s): Simon RAWLINSON Funding source: Innovate UK Start: 17-02-2021 / End: 17-02-2024 Amount: £249,854 The aim of this programme is to transfer and embed knowledge of in vitro cell testing from QMUL to Lucideon to enable them to offer clients integrated physico-chemical and biological characterisation of materials used in medical devices & implants to improve the safety & efficacy of healthcare treatments. |
Production of a human growth plate organ-chip model of skeletal developmentPrincipal Investigator: Martin KNIGHT Co-investigator(s): Timothy HOPKINS and Joanne NOLAN Funding source: National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) and BBSRC Start: 01-01-2023 / End: 01-01-2024 Amount: £201,240 This award aims to develop a human cell-based skeletal growth plate organ-on-a-chip to replace the use of rodents in some studies of development, ageing and disease |
Body-Worn Sensor for Point-of-Care Vascular Access MonitoringPrincipal Investigator: Lei SU Funding source: EPSRC Engineering and Physical Sciences Research Council Start: 01-10-2021 / End: 31-12-2023 Amount: £378,651 In this project, we will develop a body-worn sensor for cardiovascular monitoring, particularly to address a long-standing clinical challenge in vascular access health surveillance. |
Organ-on-a-chip Centre of ExcellencePrincipal Investigator: Martin KNIGHT Co-investigator(s): Hazel SCREEN and Funding source: Emulate Inc. Start: 20-08-2019 / End: 31-12-2023 Amount: £525,375 The QM-Emulate Organs-on-Chips Centre provides access to Emulate’s Organs-on-Chips technology to enable researchers to develop organ models of their design to expedite their experiments. Expert staff are on hand to support with training and use of the platform as well as pushing forward new organ-on-a-chip research projects led by Knight and Screen. The Centre also provides opportunities for collaboration with Emulate and support for commercialisation and translational impact. The centre is part of the new Centre for Predictive in vitro Models (CPM). Visit the web site to see full details of this and the new Emulate centre: https://www.cpm.qmul.ac.uk/emulate/ |
The regulation of mechanosensing in healthy and atherosclerotic VSMCPrincipal Investigator: Thomas ISKRATSCH Funding source: BHF British Heart Foundation Start: 01-12-2020 / End: 30-11-2023 Amount: £238,021 Vascular smooth muscle cellsplay a central role in the onset and progression of many cardiovascular diseases, from atherosclerosis to vascular injury, where their migration, matrix secretion, or degradation functions are deregulated. Here we are investigating how the phenotypic switch is regulated through physical/mechanical stimuli. |
Cost-effective Lung Biopsy with Intraoperative Electrical Impedance Sensing and Artificial Intelligence NavigationPrincipal Investigator: Zion TSE Funding source: NIH National Institutes of Health - USA Start: 01-11-2022 / End: 31-10-2023 Amount: £25,611 Lung cancer is the second most common cancer in both men and women. More than one million lung cancer cases are diagnosed worldwide each year. It has the highest death rate among all types of cancers in the United States and worldwide. Early detection with higher yield tissue diagnosis as well as an accurate localization during lung interventions may help reduce the impact, death rate, and overall population cost of lung cancer. Accurate and timely clinical information facilitates patient-specific therapy decisions, resulting improved clinical outcomes. Engineering approaches that are low cost and also Accurate localization of biopsy devices alongside of verification that biopsy needle is within solid abnormal tissue (and not normal non-target lung) can signi?cantly improve the accuracy of the diagnosis, which further helps clinicians make the optimal decision via a lung treatment decision tree. |
A Biophysical Model of Gum Reintegration on enamelPrincipal Investigator: Julien GAUTROT Funding source: GSK GlaxoSmithKline UK Ltd Start: 01-10-2019 / End: 30-09-2023 Amount: £32,000 |
Smartphone Application For Effective Prostate Cancer Screening With Machine Learning Enhanced PSA-density MeasurementPrincipal Investigator: Zion TSE Funding source: CR-UK Cancer Research UK Start: 25-06-2022 / End: 30-09-2023 Amount: £66,298 Prostate cancer (PCa) is the commonest male cancer. Prostate-specific antigen (PSA) testing is the first-line investigation used for referral to secondary care. Less than half of the 120,000 patients/year referred in the UK are ultimately diagnosed with PCa, highlighting the inefficiencies in the system, including the use of MRI as an expensive resource and biopsy as an invasive procedure. A common reason for raised PSA levels is benign gland overgrowth, and therefore PSA-density corrects for overgrowing gland volume, and therefore has utility for and indicating the presence of clinically significant cancer. Ultrasound (US) can measure gland volume provide such information, however, currently thisUS is currently performed in secondary care by specialized specialised practitioners, which increases costs and may delay cancer pathways. Making US volume calculations automated, cheap, and potentially available in primary care would avoid such limitations. The aims of this project are to develop a prototype device for automated US measurement of prostate volume and validate performance in a patient cohort. |
Targeting the innate immune system in high grade serous ovarian cancerPrincipal Investigator: Fran Balkwill Co-investigator(s): Olive Pearce, Daniellea Loessner, Michel Lockley, R Manchanda, Quezada S and Martin KNIGHT Funding source: CRUK Start: 01-10-2018 / End: 01-09-2023 Amount: £2,028,756 This 5-year CRUK Programme Grant is led by Prof Fran Balkwill from Barts Cancer Institute with a multidisciplinary team of co-investigators including Prof Martin Knight representing cancer bioengineering and mechanobiology. |
Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue EngineeringPrincipal Investigator: Julien GAUTROT Funding source: EU Commission - Horizon 2020 Start: 01-09-2018 / End: 31-08-2023 Amount: £2,011,161 ProLiCell will design the biochemical and mechanical properties of extracellular matrix (ECM) protein nanosheets that can sustain the formation of adhesion protein complexes and support cell proliferation and culture on materials with very weak bulk mechanical properties (liquids). |
MICA: Organ-on-a-chip models for safety testing of regenerative medicine productsPrincipal Investigator: Hazel SCREEN Co-investigator(s): Martin KNIGHT Funding source: MRC Medical Research Council Start: 24-08-2020 / End: 23-08-2023 Amount: £504,557 We are building novel organ-on-a-chip models of our musculoskeletal tissues, to learn more about disease processes and how this might be managed with regenerative medicine approaches |
The mechanics of the collagen fibrillar network in ageing cartilagePrincipal Investigator: Himadri GUPTA Co-investigator(s): Martin KNIGHT Funding source: Biotechnology and Biological Sciences Research Council Start: 01-10-2017 / End: 24-07-2023 Amount: £371,095 We seek to understand how age-related changes in articular cartilage link to alterations in its nanoscale mechanics – and eventually to joint breakdown. We use high-brilliance synchrotron X-ray scattering to track fibrillar deformation dynamics in the matrix (hydrated proteoglycans restrained by collagen fibrils), combined with proteomics to assess compositional changes. https://gtr.ukri.org/projects?ref=BB%2FR003610%2F1 |
Wafer-Scale Manufacturing of Single-Crystal Perovskite OptoelectronicsPrincipal Investigator: Lei SU Funding source: EPSRC Engineering and Physical Sciences Research Council Start: 05-07-2021 / End: 04-07-2023 Amount: £316,308 In this project we aim to develop a scalable and high-yield manufacturing process for mass-producing single-crystal perovskite optoelectronics. |