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Queen Mary University of LondonQueen Mary University of London
Research menu
Current research funding in the Division of Bioengineering
£10,749,745

Division of Bioengineering

Research Projects

The following are current externally funded research projects taking place within the Division of Bioengineering at Queen Mary University of London. (The funding values represents the QMUL portion in multi centre grants)

Diagram showing omental metastasis in high grade serous ovarian cancerTargeting the innate immune system in high grade serous ovarian cancer


Principal Investigator: Fran Balkwill
Co-investigator(s): Olive Pearce, Daniellea Loessner, Michel Lockley, R Manchanda, Quezada S and Martin KNIGHT
Funding source: CRUK
Start: 01-10-2018  /  End: 01-10-2023
Amount: £2,028,756

This 5-year CRUK Programme Grant is led by Prof Fran Balkwill from Barts Cancer Institute with a multidisciplinary team of co-investigators including Prof Martin Knight representing cancer bioengineering and mechanobiology.

Bottom up structuring of liquids without external fields or molds.
Manufacturing of anisotropic nano and micro- particles.Molecular Manufacturing of Macroscopic Objects - fellowship Stoyan Smoukov


Principal Investigator: Stoyan SMOUKOV
Funding source: EPSRC Engineering and Physical Sciences Research Council
Start: 01-09-2018  /  End: 31-08-2023
Amount: £1,180,624

This interdisciplinary proposal proposes a molecular basis for Manufacturing for the Future,[a1] to grow many types of particles in a nature-inspired way. It offers scalability, near-full utilization of the material, and the ability to carry out transformations at near ambient conditions. Manufacturing in nature spans the scales from intricate ...

Cells growing at the surface of oil dropletsEngineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue Engineering


Principal Investigator: Julien GAUTROT
Funding source: EU Commission - Horizon 2020
Start: 01-09-2018  /  End: 31-08-2023
Amount: £2,011,161

ProLiCell will design the biochemical and mechanical properties of extracellular matrix (ECM) protein nanosheets that can sustain the formation of adhesion protein complexes and support cell proliferation and culture on materials with very weak bulk mechanical properties (liquids).

UKRMP2 Acellular / Smart Materials


Principal Investigator: Alvaro MATA
Funding source: MRC Medical Research Council
Start: 06-04-2018  /  End: 15-04-2023
Amount: £40,983

Modulating tendon micromechanics for injury prevention or management


Principal Investigator: Hazel SCREEN
Funding source: EPSRC & TRB Chemedica
Start: 02-10-2017  /  End: 01-10-2021
Amount: £140,000

We are working with TRB Chemedica to understand how bio-lubricants may modulate local tendon mechanics and help manage or prevent tendon injury

Multiscale nuclear mechanobiology within the skin: from biophysical cues to epigenetic effects


Principal Investigator: Núria GAVARA
Co-investigator(s): John Connelly
Funding source: BBSRC
Start: 01-10-2017  /  End: 30-09-2021
Amount: £469,683

The overall objective of the proposed project is to understand how forces are transmitted from the external environment to the nucleus and to determine the subsequent effects on nuclear structure, gene expression, and cell function within the epidermis of the skin. We will use advanced biophysical and imaging techniques to apply forces to single cells, and systems biology methodologies to analyse the changes in DNA structure and gene expression. In addition, we will test the role of internal cellular structures, such as the cytoskeleton, to gain mechanistic insight into these processes. Finally, we will investigate the influence of nuclear mechano-sensing in more complex 3D models of human skin. This is a collaboration with Dr John Connelly (PI)

Cardiomyocyte on PDMS nanopillarInvestigating the cardiomyocyte rigidity sensing mechanism with micro patterned surfaces and nanopil


Principal Investigator: Thomas ISKRATSCH
Funding source: BBSRC Biotechnology and Biological Sciences Research Council
Start: 01-09-2018  /  End: 31-08-2021
Amount: £490,545

The composition and the stiffness of the cardiac extracellular matrix change during development or in heart disease. Cardiomyocytes and their progenitors sense these changes, which decides over Cardiomyocyte fate. Our preliminary data suggested a cardiomyocyte specific rigidity sensing mechanism which we will investigate here in detail.

Organ-on-a-Chip Technologies


Principal Investigator: Hazel SCREEN
Co-investigator(s): Martin KNIGHT
Funding source: MRC Medical Research Council
Start: 01-08-2018  /  End: 31-07-2021
Amount: £479,339

We are excited to host the UKRI Technology Touching Life funded Organ-on-a-Chip Network out of QMUL. The network aims to bring together the vibrant, multidisciplinary UK research community interested in developing and using organ-on-a-chip models and support the on going exciting research activity in this field.

The instrument will combine two electrochemical imaging techniques which measure cell responses apically and basally.Combined LAPS and SICM for multimodal live cell imaging


Principal Investigator: Steffi KRAUSE
Co-investigator(s): Wen WANG
Funding source: EPSRC Engineering and Physical Sciences Research Council
Start: 01-06-2018  /  End: 31-05-2021
Amount: £571,839

A novel instrument will be developed that will revolutionise the ability to monitor cellular processes and cell communication in polarised cells by simultaneously imaging cells apically and basally. This will provide information about apical cell morphology and basal ion concentrations and electrical signals such as cell surface charge and impedance.

Identifying the causes of age-related tendon injury


Principal Investigator: Hazel SCREEN
Funding source: DMT Dunhill Medical Trust, The
Start: 01-10-2018  /  End: 31-03-2021
Amount: £190,374

The primary goal of this project is to establish how and where in tendon tendinopathy originates, and to define how the age-related changes in tendon accelerate progression to tendinopathy. Our goal is to identify the specific IFM changes that drive increased injury risk with ageing. This is exciting as we can then continue, in future studies, to develop treatments specifically aimed at preventing, reversing, or mitigating the effects of these changes.

Development of mechanically enhanced osteoinductive synthetic bone graft substitutes


Principal Investigator: Karin HING
Funding source: Apatech Ltd
Start: 01-10-2017  /  End: 31-03-2021
Amount: £87,500

The aim of this project is to develop and test a series of bone graft substitutes with novel pore structures using a perfusion based bioreactor system with flow to waste and closed loop capabilities, that is also able to subject real bone graft substitute granules to direct mechanical perturbation. This system has been validated using human mesenchymal stem cells seeded on BGS with varied strut porosity and will be further optimised to enable screening of new structures.

Cells proliferating on nanosheets self-assembled at liquid-liquid interfaces2D composites with controlled nano-mechanisms


Principal Investigator: Julien GAUTROT
Funding source: Leverhulme Trust
Start: 01-03-2018  /  End: 28-02-2021
Amount: £231,825

A long standing dogma in cell-based technologies is that bulk mechanical properties of solid substrates are essential to enable cell adhesion, proliferation and differentiation. However, the use of solid materials for cell culture constitutes an important hurdle for the scale up and automation of processes. We recently discovered that protein assembly at liquid-liquid interfaces results in mechanically strong protein layers sustaining cell spreading and directing fate decision. For long term culture, such interfaces lacked toughness and ruptured. This project will develop tough 2D nanocomposites assembled at oil-water interfaces and sustaining long term stem cell culture for applications in regenerative medicine.

Hole found in the fetal membranes ten weeks after fetoscopic intervention. The surgeon created a hole through the fetal membranes to fix the problem with the baby's placenta. However, the hole never healed leading to premature rupture of the fetal membranHealing the fetal membranes after iatrogenic PPROM


Principal Investigator: Tina CHOWDHURY
Co-investigator(s): Anna David, Alvaro MATA, Dan BADER, David Becker and Jan Deprest
Funding source: Sparks charity
Start: 01-02-2018  /  End: 31-01-2021
Amount: £148,863

The integrity of the fetal membranes that surrounds the baby in the womb during pregnancy are vital for normal development. Once the fetal membranes have ruptured or are damaged, they fail to heal leaving a defect until the end of pregnancy. Bacteria may subsequently ascend from the vagina into the womb, causing infection both to the fetus and mother. This condition is called pre-term premature rupture of the foetal membrane (PPROM), and is a common cause of preterm birth. PPROM also complicates 30% of fetal surgeries that are increasingly being used to treat abnormalities in the unborn baby such as spine, diaphragmatic and placental defects. However, PPROM and subsequent preterm birth compromises the outcome of treated babies, reducing the clinical effectiveness of foetal surgery. There are no clinical solutions to improve healing of the foetal membrane after it ruptures.

3D Printed Osteogenic & Hierarchal Bio Mineralizing Scaffold


Principal Investigator: Alvaro MATA
Funding source: AO Foundation
Start: 01-06-2017  /  End: 30-11-2020
Amount: £114,082

The project will look to develop 3D printed polymeric scaffolds capable of acellular mineralization for enhancing integration of implants in maxillofacial applications.

Biomineralizing coatings for maxillofacial implants


Principal Investigator: Alvaro MATA
Funding source: EU Commission - Horizon 2020
Start: 01-05-2019  /  End: 31-10-2020
Amount: £112,347

The project aims to translate a mineralising coating that can be grown on 3D printed implants for bone augmentation of the mandibular area.

Raster scanning the focusing at the tip of an imaging optical fibreTHESIS


Principal Investigator: Lei SU
Co-investigator(s): Martin KNIGHT and Luming ZHAO
Funding source: EU Commission - Horizon 2020
Start: 01-10-2018  /  End: 30-09-2020
Amount: £156,364

In this project, the Marie Curie Fellow will develop an optical fibre based image-guided surgery system based on the state-of-the-art optical-fibre laser technologies.

Micropatterned siliconesNovel Cross-linking Strategy


Principal Investigator: Julien GAUTROT
Funding source: FormFormForm Ltd
Start: 01-10-2017  /  End: 30-09-2020
Amount: £105,971

This project focuses on the design of novel crosslinking strategies for silicone materials. These will enable the design of a new generation of silicone based composites with controlle mechanical properties and displaying conductive behaviour. The project will explore the use of these materials for 3D printing.

Fibrillar level mechanisms underlying transient change in pre-strain in cartilage: Under loading, loss of water molecules and structural collapse in the proteoglycan network lead a transient reduction of pre-strain (reduction in D-period) in the collagenThe mechanics of the collagen fibrillar network in ageing cartilage


Principal Investigator: Himadri GUPTA
Co-investigator(s): Martin KNIGHT
Funding source: B.B.S.R.C.
Start: 01-10-2017  /  End: 30-09-2020
Amount: £369,875

We seek to understand how age-related changes in articular cartilage link to alterations in its nanoscale mechanics – and eventually to joint breakdown. We use high-brilliance synchrotron X-ray scattering to track fibrillar deformation dynamics in the matrix (hydrated proteoglycans restrained by collagen fibrils), combined with proteomics to assess compositional changes.

Biomechanical determinants of advanced coronary atherosclerotic plaque formation in transgenic hyperlipidaemic minipigs


Principal Investigator: Rob KRAMS
Funding source: BHF British Heart Foundation
Start: 01-11-2018  /  End: 03-09-2020
Amount: £167,563

Sensory and Supporting Cells in the Organ of Corti


Principal Investigator: Nuria GAVARA
Funding source: M.R.C.
Start: 01-09-2015  /  End: 31-08-2020
Amount: £44,946

The aim of this project is to study force transmisison within the cochlea as it is mechanically stimulated by sound. This programme grant is lead by Brighton U. and features a combination of experimental approaches and novel modelling analysis. Our lab uses AFM to mechanically characterize speciallized cells in the cochlea, so that mechanical parameters can be fed into new models.

THaCH - The effects of hypercholesterolemia on tendon health


Principal Investigator: Hazel SCREEN
Co-investigator(s): Charlotte Waugh and Alex Scott
Funding source: Commission of the European Community / Commission of the European Community
Start: 31-08-2016  /  End: 21-08-2020
Amount: £64,209

Musculoskeletal diseases cause pain and suffering to millions of people worldwide. This proposal aims to significantly enhance our understanding of hypercholesterolemia on aspects of tendon health, a highly under-researched area and one of significant clinical importance. The findings from the proposed research are likely to have major implications for orthopedic sciences and preventative medicine as well as rehabilitation services, strategies and technology. Such knowledge has the potential to improve quality of life and reduce socio-economic costs associated with the disability resulting from orthopedic and musculoskeletal diseases.

META-DORM


Principal Investigator: Martin KNIGHT
Co-investigator(s): Stefaan VERBRUGGEN
Funding source: Commission of the European Community
Start: 01-01-2018  /  End: 31-07-2020
Amount: £137,844

This study seeks to explore the interactions between bone cells, cancer cells and their physical environment and the role of primary cilia, aiming to expand our knowledge of how cancer spreads to bone from other organs.

Supramolecular peptide nanotechnology for antimicrobial therapies


Principal Investigator: Helena AZEVEDO
Funding source: Wellcome Trust
Start: 01-05-2019  /  End: 30-04-2020
Amount: £99,986

Antimicrobials remain the main means to treat and control bacterial infections. Their efficacy is now compromised due to overuse in humans, animals, agriculture, with bacteria developing resistance that renders certain antibiotics ineffective. Infections due multi-drug resistant (MDR) bacteria have emerged as one of the most significant global threats to human and animal health in the 21st century. Thus, the development of new antibiotics, or better ways to deliver conventional antibiotics more effectively, is an urgent priority. This project is focused on the formulation and assessment of novel self-assembled peptide nanocarriers, able to restore and/or enhance the activity of known antibiotics against MDR bacteria.

Investigation of chemotaxis in modulating smart behaviour in synthetic bone graft substitutes


Principal Investigator: Karin HING
Co-investigator(s): Simon Rawlinson
Funding source: Baxter Healthcare Corporation
Start: 01-01-2015  /  End: 31-03-2020
Amount: £66,099

Silicate substituted apatite bone grafts have an enhanced capacity to stimulate bone regeneration. Moreover, altering the level of strut porosity has the capacity to confer osteoinductive behaviour to these graft materials. The aim of this project is to investigate whether these phenomena are related to more efficient cell recruitment and tasking, through (i) exchange of Ca, PO4 and SiO4 ions, and/or (ii) optimal sequestering and enrichment of native signalling molecules.

Thin polymer films and surface functionalisation chemistry.


Principal Investigator: Pankaj VADGAMA
Funding source: Camstech Ltd, Campus Technology Hub,
Start: 15-10-2018  /  End: 31-12-2019
Amount: £3,109

Polymer thin films are being coated on optically active silver and gold nanoparticles for hand held biosensing.

Mechno-regulation of genome function to direct stem cell rate


Principal Investigator: David LEE
Co-investigator(s): Nuria GAVARA
Funding source: B.B.S.R.C.
Start: 01-01-2017  /  End: 31-12-2019
Amount: £436,194

Mechno-regulation of genome function to direct stem cell rate

Osteoarthritis may be treated as an environmental ciliopathy


Principal Investigator: Martin KNIGHT
Co-investigator(s): Paul Chapple, Phil Beales, Hannah Mitchinson and
Funding source: MRC
Start: 01-09-2014  /  End: 30-11-2019
Amount: £365,598

This study tests the hypothesis that pathological alterations in the cartilage microenvironment regulate chondrocyte primary cilia structure leading to changes in cilia signalling which drive cartilage degradation.    Increasing evidence suggests that primary cilia and the associated signalling pathways are critical for the health of articular cartilage ...

Impact of Physiogel on tribological properties and structural integrity of the skin


Principal Investigator: Julien GAUTROT
Funding source: GSK GlaxoSmithKline UK Ltd
Start: 01-09-2018  /  End: 30-11-2019
Amount: £144,385

Super resolution image of a primary ciliumInnovation Fund: High-throughput Library Screen


Principal Investigator: Martin KNIGHT
Co-investigator(s): Clare THOMPSON and Chleo Bishop
Funding source: B.B.S.R.C.
Start: 01-09-2016  /  End: 31-10-2019
Amount: £9,960

Measuring local strain distributions through the equine SDFT as a novel indicator of injury risk: effective injury management and prevention


Principal Investigator: Hazel SCREEN
Funding source: Horserace Betting Levy Board
Start: 01-07-2016  /  End: 10-05-2019
Amount: £167,426

In this project we are developing novel uses of ultrasound imaging, to investigate the strains in the equine SDFT during use. We think that alterations in strain fields in the tendon occur during injury and by finding methods to measure these we can more easily manage tendon health

Biomimetic mineralization for enamel regeneration - ENAMULATE


Principal Investigator: Alvaro MATA
Funding source: Commission of the European Community
Start: 01-11-2017  /  End: 30-04-2019
Amount: £112,296

Dental enamel has a unique chemical composition and a remarkable well-defined hierarchical structure, which together are responsible for its outstanding properties and critical functionality. Once lost, this tissue cannot be regenerated and is directly involved in a variety of dental problems that affect a large percentage of the world population. ...