British Heart Foundation – 4 year Doctoral Training Programme

Led by Professors Amrita Ahluwalia and Tim Warner and involving 23 named researchers, the BHF DTP Programme provides cohort training leading to a PhD in cardiovascular research.

Tomo-SAXS: Imaging full-field molecular-to-macroscale biophysics of fibrous tissues

KTP with Lucideon: Cell testing to assist development of novel biomaterials

The aim of this programme is to transfer and embed knowledge of in vitro cell testing from QMUL to Lucideon to enable them to offer clients integrated physico-chemical and biological characterisation of materials used in medical devices & implants to improve the safety & efficacy of healthcare treatments.

The regulation of mechanosensing in healthy and atherosclerotic VSMC

Vascular smooth muscle cellsplay a central role in the onset and progression of many cardiovascular diseases, from atherosclerosis to vascular injury, where their migration, matrix secretion, or degradation functions are deregulated. Here we are investigating how the phenotypic switch is regulated through physical/mechanical stimuli.

A Biophysical Model of Gum Reintegration on enamel

Organ-on-a-chip Centre of Excellence

The QM-Emulate Organs-on-Chips Centre provides access to Emulate’s Organs-on-Chips technology to enable researchers to develop organ models of their design to expedite their experiments. Expert staff are on hand to support with training and use of the platform as well as pushing forward new organ-on-a-chip research projects led by Knight and Screen. The Centre also provides opportunities for collaboration with Emulate and support for commercialisation and translational impact. The centre is part of the new Centre for Predictive in vitro Models (CPM). Visit the web site to see full details of this and the new Emulate centre: https://www.cpm.qmul.ac.uk/emulate/

Targeting the innate immune system in high grade serous ovarian cancer

This 5-year CRUK Programme Grant is led by Prof Fran Balkwill from Barts Cancer Institute with a multidisciplinary team of co-investigators including Prof Martin Knight representing cancer bioengineering and mechanobiology.

Molecular Manufacturing of Macroscopic Objects - fellowship Stoyan Smoukov

This interdisciplinary proposal proposes a molecular basis for Manufacturing for the Future,[a1] to grow many types of particles in a nature-inspired way. It offers scalability, near-full utilization of the material, and the ability to carry out transformations at near ambient conditions. Manufacturing in nature spans the scales from intricate ...

Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue Engineering

ProLiCell will design the biochemical and mechanical properties of extracellular matrix (ECM) protein nanosheets that can sustain the formation of adhesion protein complexes and support cell proliferation and culture on materials with very weak bulk mechanical properties (liquids).

MICA: Organ-on-a-chip models for safety testing of regenerative medicine products

We are building novel organ-on-a-chip models of our musculoskeletal tissues, to learn more about disease processes and how this might be managed with regenerative medicine approaches

Organ-on-a-chip model of breast cancer bone metastases

Background A common site for invasive ductal carcinomas (IDC) metastasis is bone, affecting about 70% of patients. Once metastasis to bone has occurred the five-year survival rate drops from 99% to 29%.  How breast cancer metastasises to bone is poorly understood, partly because of the lack of appropriate models. Organ-on-a-chip technology is …

UKRMP2 Acellular / Smart Materials

Graphene Flagship Core Project 3

This grant will cofund the establishing of a mini-CDT with 5 PhD studentships in Graphene materials at QMUL.

Emulate Organs-on-Chips Centre Technician

Body-Worn Sensor for Point-of-Care Vascular Access Monitoring

In this project, we will develop a body-worn sensor for cardiovascular monitoring, particularly to address a long-standing clinical challenge in vascular access health surveillance.

3D Photoelectrochemical Imaging in Porous Light-Addressable Structures

The project aims to develop a photoelectrochemical imaging system for mapping of electrochemical processes in three dimensions within porous electrode structures. The new technology will aid the development of novel electrode materials for energy harvesting devices and be suitable for in-situ 3D functional imaging in 3D tissue culture.

Combined LAPS and SICM for multimodal live cell imaging

A novel instrument will be developed that will revolutionise the ability to monitor cellular processes and cell communication in polarised cells by simultaneously imaging cells apically and basally. This will provide information about apical cell morphology and basal ion concentrations and electrical signals such as cell surface charge and impedance.

Protein Nanosheet-Stabilised Emulsions for Next Generation Biomanufacturing

Investigating the cardiomyocyte rigidity sensing mechanism with micro patterned surfaces and nanopil

The composition and the stiffness of the cardiac extracellular matrix change during development or in heart disease. Cardiomyocytes and their progenitors sense these changes, which decides over Cardiomyocyte fate. Our preliminary data suggested a cardiomyocyte specific rigidity sensing mechanism which we will investigate here in detail.

EPSRC Core Equipment 2020

Bench-top single optical fibre microendoscope- IAA Large grant

This project aims to develop a benchtop single optical fibre imaging probe.

Super-Resolution Microscopy of live cells in 3D

This project funds the acquisition of a novel super resolution microscope, OMX-FLEX, which will be used to develop a range of new techniques enabled by fast 3D Super-Resolution imaging of live-cells.

Healing the fetal membranes after iatrogenic PPROM

The integrity of the fetal membranes that surrounds the baby in the womb during pregnancy are vital for normal development. Once the fetal membranes have ruptured or are damaged, they fail to heal leaving a defect until the end of pregnancy. Bacteria may subsequently ascend from the vagina into the womb, causing infection both to the fetus and mother. This condition is called pre-term premature rupture of the foetal membrane (PPROM), and is a common cause of preterm birth. PPROM also complicates 30% of fetal surgeries that are increasingly being used to treat abnormalities in the unborn baby such as spine, diaphragmatic and placental defects. However, PPROM and subsequent preterm birth compromises the outcome of treated babies, reducing the clinical effectiveness of foetal surgery. There are no clinical solutions to improve healing of the foetal membrane after it ruptures.

Drug repurposing for treatment of cilia-related pathologies

This project funded by Queen Mary Innovations, will identify compounds for the treatment of a rare genetic disease, Jeune Syndrome, that disrupts skeletal formation associated with dysregulation of primary cilia.

Newton International Fellowship 2019: Dynamics of microcapsules in inertial two-phase flows

Dynamics of microcapsules in inertial two-phase flows

Incorporating the circadian clock into organ-on-a-chip systems

Studies to support the development of more physiologically relevant in vitro model systems which incorporate the circadian clock.

Incorporating the circadian clock into Organ-on-a-chip (OOAC) devices

Studies to support the development of more physiologically relevant in vitro model systems which incorporate the circadian clock

Bioresorbable bioactive composites Kick off

Novel capsule based smell test for the assessment of hyposmia/anosmia

This project is to develop a cheap, scalable and rapid smell test for the assessment of hyposmia/anosmia including COVID19 related symptom in humans. The prototype test consists of a standardized number of aromatic oils capsules fabricated by coaxial dripping and placed between adhesive strips that users crush and pull apart to release the smell.

Newton Mobility Grant-Prof B Garipcan: Directing fibre orientation in self-assembling peptide/polymer hydrogels via thermal manipulation

Open characterisation and modelling environment to drive innovation in advanced nano-architectured and bio-inspired hard/soft interfaces (OYSTER)

Major focus of the project is in surface design, controlled adhesion and development of surface characterisation techniques and their standardization. In particular, Nanoforce contribution in the project and relevant tasks are crossing other activity at SEMS what includes biofunctionalisation of surfaces to make hydrophobic surface hydrophilic and to produce thin polymeric films with micro-packaged bioactive agents. Also SEMS expertise in polymer processing will be expanded on polymer with drug coating. Further goal would be to make such a coating on various implants and stents. Developments of implants with designed mechanical properties could benefit with extra function added on it such as “micro-packaged” drug what could be used either to proliferate cell grow in case of grow factor encapsulation or, if needed, coatings antibacterial properties.

Light4Sight - Light-activated carriers for the controlled delivery of therapeutic peptides in posterior segment eye diseases

The growth of the ophthalmic drug market is primarily driven by an increasing aged population suffering from age- and lifestyle-related diseases such as macular degeneration, diabetic retinopathy, glaucoma, among others. These diseases cause moderate or complete vision loss, resulting in significant reduction in quality of life. Consequently, innovative approaches for the effective delivery of biopharmaceuticals for the treatment of chronic intraocular diseases are required. Currently, intravitreal injection of drugs is the most acceptable and effective method to treat vitreoretinal diseases. By placing the drug in the posterior eye, it evades the ocular barriers common in topical and systemic delivery, allowing higher drug doses to reach the target site. However, treatments require frequent injections to maintain adequate intraocular concentration, which are invasive, increase the risk of adverse effects and pose significant treatment burden on patients and healthcare providers. Thus, alternative ways to deliver these drugs that require less frequent administration need to be developed. Light4Sight aims to develop a novel delivery platform consisting of self-assembling nanocarriers incorporating therapeutic peptides and suspended within a light-sensitive supramolecular hydrogel. The hydrogel can be injected in the vitreous and release of nanocarriers be activated through the irradiation of visible light. This approach provides several benefits: 1) minimizes the use of repeated injections reducing treatment burden; 2) reduces burst release of the nanocarriers avoiding potential dose related toxicity; 3) on-demand release to match patient needs; 4) allows high drug loading for longterm therapy; 5) protects peptide drugs from rapid clearance in the vitreous increasing their half-life.