Prof Rob Krams
MD, PhD
All Publications
Page 1 of 5
2024
- Bourantas C, Torii R, Karabasov S and Krams R (2024). Editorial: Computational modelling of cardiovascular hemodynamics and machine learning. Frontiers in Cardiovascular Medicine, Frontiers vol. 11
22-02-2024 - Savvopoulos F, Keeling MC, Carassiti D, Fogell NA, Patel MB, Naser J, Gavara N, de Silva R and Krams R (2024). Assessment of the nano-mechanical properties of healthy and atherosclerotic coronary arteries by atomic force microscopy. Journal of The Royal Society Interface, The Royal Society vol. 21 (211)
01-02-2024 - Popovs S, Munkevics M, Krama T, Krams R, Sledevskis E, Trakimas G, Zants K, Grigorjeva T, Mizers V, Kolbjonoks V, Jõers P and Krams I (2024). Explaining the survival of the sickest: altered walking patterns are linked with improved adult survival in Drosophila melanogaster grown with predators during larval development. Behaviour, Brill Academic Publishers vol. 161 (2), 133-148.
09-01-2024
2023
- Bajaj R, Huang X, Alves-Kotzev N, Weyers J, Levine M, Garg M, Maung S, Bransby K, Torii R, Krams R, Garcia-Garcia HM, Raber L, Mathur A, Baumbach A, Zhang Q, Courtney B and Bourantas C (2023). TCT-613 Comparison of Histology-Trained Deep Learning Approach With Human Expert Analysts for Automated Plaque Component Classification in Hybrid Intravascular Ultrasound-Optical Coherence Tomography Images. Journal of The American College of Cardiology, Elsevier vol. 82 (17), b246-b247.
01-10-2023 - Morgan B, Murali AR, Preston G, Sima YA, Chamorro LM, Bourantas C, Torii R, Mathur A, Baumbach A, Jacob M, Karabasov S and Krams R (2023). A physics-based machine learning technique rapidly reconstructs the wall-shear stress and pressure fields in coronary arteries. Frontiers in Cardiovascular Medicine, Frontiers Media
29-09-2023 - Fogell NAT, Patel M, Yang P, Ruis RM, Garcia DB, Naser J, Savvopoulos F, Davies Taylor C, Post AL, Pedrigi RM, de Silva R and Krams R (2023). Considering the Influence of Coronary Motion on Artery-Specific Biomechanics Using Fluid–Structure Interaction Simulation. Annals of Biomedical Engineering, Springer vol. 51 (9), 1950-1964.
12-07-2023 - Çap M, Torii R, Onuma Y, Krams R, Bennett MR, Stone PH, Serruys PW and Bourantas CV (2023). Editorial: Computational modeling for assessing coronary artery pathophysiology. Frontiers in Cardiovascular Medicine, Frontiers Media vol. 10
17-01-2023 - Krama T, Munkevics M, Krams R, Grigorjeva T, Trakimas G, Jõers P, Popovs S, Zants K, Elferts D, Rantala MJ, Sledevskis E, Contreras-Garduño J, de Bivort BL and Krams IA (2023). Development under predation risk increases serotonin-signaling, variability of turning behavior and survival in adult fruit flies Drosophila melanogaster. Frontiers in Behavioral Neuroscience vol. 17
01-01-2023
2022
- Souilhol C, Ayllon BT, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ, Ariaans M, Li J, Fang Y, Jørgensen HF, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, Francis SE, Chico TJA, Serbanovic-Canic J and Evans PC (2022). JAG1-NOTCH4 mechanosensing drives atherosclerosis. Science Advances, American Association For The Advancement of Science vol. 8 (35)
02-09-2022 - Bajaj R, Huang X, Alves N, Weyers J, Levine M, Garg M, Maung S, Bransby K, Torii R, Krams R, Garcia-Garcia H, Mathur A, Baumbach A, Zhang Q, Courtney B and Bourantas C (2022). TCT-254 Histology-Trained Deep Learning Methodology for Automated Coronary Plaque Component Classification in Combined Intravascular Ultrasound-Optical Coherence Tomography Images. Journal of The American College of Cardiology, Elsevier vol. 80 (12)
01-09-2022
2021
- Herault S, Naser J, Carassiti D, Chooi KY, Nikolopoulou R, Font ML, Patel M, Pedrigi R and Krams R (2021). Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells. Biophysical Reviews, Springer (Part of Springer Nature) vol. 13 (5), 787-796.
23-10-2021 - Naser J, Fogell N, Patel M, Yang P, Krams R, Wentzel JJ, Aben JP and De Silva R (2021). Moving shear stress towards the clinic: preclinical comparison of optical coherence tomography-based versus angiography-based time-averaged wall shear stress estimations. European Heart Journal vol. 42 (Supplement_1)
12-10-2021 - (2021). Correction: BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model. Heart, Bmj vol. 107 (19), e10-e10.
14-09-2021 - Patel M, Savvopoulos F, Berggren CC, Aslanidou L, Timmins LH, de Silva R, Pedrigi RM and Krams R (2021). Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis. Journal of Biomechanics, Elsevier vol. 128
28-08-2021
2020
- Post AL, Cernohorsky P, Pedrigi RM, Streekstra GJ, d’Hooghe JNS, Annema JT, Strackee SD, Krams R, van Leeuwen TG, de Bruin DM and Faber DJ (2020). 3D co-registration algorithm for catheter-based optical coherence tomography. Optics Continuum, Optica Publishing Group vol. 3 (10)
17-09-2020 - Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU, Koning G, Onuma Y, Zanchin C, Krams R, Mathur A, Baumbach A, Mintz G, Windecker S, Lansky A, Maehara A, Stone PH, Raber L and Stone GW (2020). Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events. Jacc Cardiovascular Imaging, Elsevier vol. 13 (10), 2206-2219.
13-05-2020 - Evans RJ, Lavin B, Phinikaridou A, Chooi KY, Mohri Z, Wong E, Boyle JJ, Krams R, Botnar R and Long NJ (2020). Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque. Nanotheranostics, Ivyspring International Publisher vol. 4 (4), 184-194.
01-01-2020
2019
- Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J, Edelman E, Evans P, van der Heiden K, Hose R, Koo B-K, Krams R, Marsden A, Migliavacca F, Onuma Y, Ooi A, Poon E, Samady H, Stone P, Takahashi K, Tang D, Thondapu V, Tenekecioglu E, Timmins L, Torii R, Wentzel J and Serruys P (2019). Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications. European Heart Journal, Oxford University Press (Oup)
30-09-2019 - Baumbach A (2019). Reliable in Vivo Intravascular Imaging Plaque Characterisation: A Challenge Unmet. American Heart Journal, Elsevier
23-07-2019 - Mohri Z, Del Rio Hernandez A and Krams R (2019). The emerging role of YAP/TAZ in mechanotransduction. J Thorac Dis vol. 9 (5), E507-E509.
01-05-2019 - Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR, Bijlenga P, Cuhlmann S, Evans P, Kwak BR, Ventikos Y and Krams R (2019). Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo. Sci Rep vol. 9 (1), 4738-4738.
18-03-2019 - Poulsen CB, Pedrigi RM, Pareek N, Kilic ID, Holm NR, Bentzon JF, Bøtker HE, Falk E, Krams R and de Silva R (2019). Plaque burden influences accurate classification of fibrous cap atheroma by in vivo optical coherence tomography in a porcine model of advanced coronary atherosclerosis. Eurointervention vol. 14 (10), 1129-1135.
20-02-2019
2018
- Abuammah A, Maimari N, Towhidi L, Frueh J, Chooi KY, Warboys C and Krams R (2018). New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress. Current Opinion in Biomedical Engineering vol. 5, 96-104.
01-03-2018
2017
- Seneviratne AN, Edsfeldt A, Cole JE, Kassiteridi C, Swart M, Park I, Green P, Khoyratty T, Saliba D, Goddard ME, Sansom SN, Goncalves I, Krams R, Udalova IA and Monaco C (2017). Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis. Circulation, American Heart Association, Inc vol. 136 (12), 1140-1154.
11-07-2017 - Denis J-F, Scheckenbach KEL, Pfenniger A, Meens MJ, Krams R, Miquerol L, Taffet S, Chanson M, Delmar M and Kwak BR (2017). Connexin40 controls endothelial activation by dampening NFκB activation. Oncotarget, Impact Journals vol. 8 (31), 50972-50986.
22-03-2017
2016
- Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C, Bowden N, Ashton J-P, Walczak H, Firmin D, Krams R, Mason JC, Haskard DO, Sherwin S, Ridger V, Chico TJA and Evans PC (2016). Zebrafish Model for Functional Screening of Flow-Responsive Genes. Arterioscler Thromb Vasc Biol, Wolters Kluwer Health, Inc vol. 37 (1), 130-143.
10-11-2016 - Pedrigi RM, Papadimitriou KI, Kondiboyina A, Sidhu S, Chau J, Patel MB, Baeriswyl DC, Drakakis EM and Krams R (2016). Disturbed Cyclical Stretch of Endothelial Cells Promotes Nuclear Expression of the Pro-Atherogenic Transcription Factor NF-κB. Ann Biomed Eng, Springer Nature vol. 45 (4), 898-909.
27-10-2016 - Pedrigi RM, Mehta VV, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L, de Silva R, Petretto E and Krams R (2016). Influence of shear stress magnitude and direction on atherosclerotic plaque composition. Royal Society Open Science, The Royal Society vol. 3 (10)
01-10-2016 - Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Del Rio Hernandez A, Towhidi L, Pedrigi RM, Homma T and Krams R (2016). Development of a synthetic gene network to modulate gene expression by mechanical forces. Sci Rep, Springer Nature vol. 6, 29643-29643.
12-07-2016 - Denis J-F, Scheckenbach L, Pfenniger A, Meens M, Krams R, Miquerol L, Taffet S, Chanson M, Delmar M and Kwak B (2016). 0109 : Connexin40 controls endothelial activation by dampening NF B activation. Archives of Cardiovascular Diseases Supplements vol. 8 (3), 203-203.
01-04-2016 - Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW, Delorenzi M and Krams R (2016). Comparison between direct and reverse electroporation of cells in situ: a simulation study. Physiological Reports, Wiley vol. 4 (6)
01-03-2016 - Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R and Monaco C (2016). Corrigendum to “Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques” [J Mol Cell Cardiol] 89B (2015) 168–172. Journal of Molecular and Cellular Cardiology, Elsevier vol. 91
01-02-2016 - Maimari N, Pedrigi RM, Russo A, Broda K and Krams R (2016). Integration of flow studies for robust selection of mechanoresponsive genes. Thrombosis and Haemostasis, Thieme vol. 115 (03), 474-483.
01-01-2016
2015
- Antonacci G, Pedrigi RM, Kondiboyina A, Mehta VV, de Silva R, Paterson C, Krams R and Török P (2015). Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma. Journal of The Royal Society Interface, The Royal Society vol. 12 (112)
01-11-2015 - Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R and Monaco C (2015). Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques. Journal of Molecular and Cellular Cardiology, Elsevier vol. 89 (Pt B), 168-172.
30-10-2015 - Pfenniger A, Meens MJ, Pedrigi RM, Foglia B, Sutter E, Pelli G, Rochemont V, Petrova TV, Krams R and Kwak BR (2015). Shear stress-induced atherosclerotic plaque composition in ApoE−/− mice is modulated by connexin37. Atherosclerosis, Elsevier vol. 243 (1), 1-10.
25-08-2015 - Pedrigi RM, Poulsen CB, Mehta VV, Ramsing Holm N, Pareek N, Post AL, Kilic ID, Banya WAS, Dall'Ara G, Mattesini A, Bjørklund MM, Andersen NP, Grøndal AK, Petretto E, Foin N, Davies JE, Di Mario C, Fog Bentzon J, Erik Bøtker H, Falk E, Krams R and de Silva R (2015). Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs. Circulation, Wolters Kluwer vol. 132 (11), 1003-1012.
15-07-2015 - Shamout FE, Pouliopoulos AN, Lee P, Bonaccorsi S, Towhidi L, Krams R and Choi JJ (2015). Enhancement of Non-Invasive Trans-Membrane Drug Delivery Using Ultrasound and Microbubbles During Physiologically Relevant Flow. Ultrasound in Medicine & Biology, Elsevier vol. 41 (9), 2435-2448.
09-06-2015 - Kis Z, Pereira HS, Homma T, Pedrigi RM and Krams R (2015). Mammalian synthetic biology: emerging medical applications. Journal of The Royal Society Interface, The Royal Society vol. 12 (106)
01-05-2015 - Dent MR, López-Duarte I, Dickson CJ, Geoghegan ND, Cooper JM, Gould IR, Krams R, Bull JA, Brooks NJ and Kuimova MK (2015). Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors. Physical Chemistry Chemical Physics, Royal Society of Chemistry (Rsc) vol. 17 (28), 18393-18402.
01-01-2015
2014
- Mohri Z, Rowland EM, Clarke LA, De Luca A, Peiffer V, Krams R, Sherwin SJ and Weinberg PD (2014). Elevated Uptake of Plasma Macromolecules by Regions of Arterial Wall Predisposed to Plaque Instability in a Mouse Model. Plos One, Public Library of Science (Plos) vol. 9 (12)
22-12-2014 - Towhidi L, Maimari N, Kis Z, Khodadadi D and Krams R (2014). A novel high-throughput platform for siRNA transfection of primary mammalian cells. Atherosclerosis, Elsevier vol. 237 (2)
01-12-2014 - Maimari N, Towhidi L, Oh D, Broda K, Russo A and Krams R (2014). A novel integrated platform for gene network inference and validation: beyond the dream consortium. Atherosclerosis, Elsevier vol. 237 (2)
01-12-2014 - Pereira G and Krams R (2014). Forecasting vulnerable plaque response to aemorheological flow. Atherosclerosis, Elsevier vol. 237 (2)
01-12-2014 - Mehta VV, Pedrigi RM, Bovens SM, Tremoleda JL, Gsell W and Krams R (2014). Longitudinal predictive analysis of vulnerable plaques in a mouse model of atherosclerosis. Atherosclerosis, Elsevier vol. 237 (2)
01-12-2014 - Maimari N, Broda K, Kakas A, Russo A and Krams R (2014). Symbolic representation and inference of regulatory networks: uncovering mechanosensitive gene networks. Atherosclerosis, Elsevier vol. 237 (2)
01-12-2014 - Kwak BR, Bäck M, Bochaton-Piallat M-L, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ and Evans PC (2014). Biomechanical factors in atherosclerosis: mechanisms and clinical implications. European Heart Journal, Oxford University Press (Oup) vol. 35 (43), 3013-3020.
17-09-2014 - Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC (2014). In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106. Molecular Imaging, Sage Publications vol. 13 (6)
01-08-2014 - Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC (2014). In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106. Mol Imaging vol. 13 (6)
01-08-2014 - Pedrigi RM, de Silva R, Bovens SM, Mehta VV, Petretto E and Krams R (2014). Thin-Cap Fibroatheroma Rupture Is Associated With a Fine Interplay of Shear and Wall Stress. Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 34 (10), 2224-2231.
24-07-2014