Prof Martin Knight
BEng, MSc, PhD, FHEA
Key Publications
- A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells
Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR and Knight MM
Advanced Science, Wiley vol. 11 (2), 2305842-2305842.
15-11-2023 - YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression
Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 31 (5), 600-612.
08-11-2022 - Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM
Cancers, Mdpi vol. 13 (12)
10-06-2021 - Polycystin-2 is required for chondrocyte mechanotransduction and traffics to the primary cilium in response to mechanical stimulation
Thompson C, Mcfie M, Chapple J, BEALES P and Knight M
International Journal of Molecular Sciences, Mdpi Ag
21-04-2021 - Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers.
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR
Cancer Discov
01-12-2017
All Publications
Page 1 of 3
2025
- Engineering growth factor gradients to drive spatiotemporal tissue patterning in organ-on-a-chip systems
Hopkins T, Midha S, Grossemy S, Screen HRC, Wann AKT and Knight MM
Journal of Tissue Engineering vol. 16
18-04-2025
2024
- Nonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit
Badar W, Inamdar SR, Fratzl P, Snow T, Terrill NJ, Knight MM and Gupta HS
Advanced Science, Wiley, e2407649-e2407649.
11-11-2024 - Air Pollution and Osteoporosis
Allen O, Knight MM and Verbruggen SW
Current Osteoporosis Reports, Springer Science and Business Media Llc
20-09-2024 - A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer
Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT, Scarpa A, Wang W, Knight M, Loessner D, Heeschen C, Mata A and Pearce OMT
Advanced Healthcare Materials, Wiley vol. 13 (17)
22-03-2024
2023
- A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells
Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR and Knight MM
Advanced Science, Wiley vol. 11 (2), 2305842-2305842.
15-11-2023 - Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment
Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT and Knight MM
Biomedical Materials, Iop Publishing vol. 18 (6)
10-10-2023 - Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW
Cancers, Mdpi vol. 15 (3)
19-01-2023
2022
- YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression
Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 31 (5), 600-612.
08-11-2022 - Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion
Hayward M-K, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF and Jones JL
Npj Breast Cancer, Springer Nature vol. 8 (1)
20-09-2022 - Collagen pre-strain discontinuity at the bone—Cartilage interface
Badar W, Ali H, Brooker ON, Newham E, Snow T, Terrill NJ, Tozzi G, Fratzl P, Knight MM and Gupta HS
Plos One, Public Library of Science (Plos) vol. 17 (9)
15-09-2022 - Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems
Heywood HK, Gardner L, Knight MM and Lee DA
In Vitro Models, Springer Nature, 1-8.
31-08-2022
2021
- Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage
Inamdar SR, Prévost S, Terrill NJ, Knight MM and Gupta HS
Acta Biomaterialia, Elsevier vol. 136, 314-326.
24-11-2021 - Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM
Cancers, Mdpi vol. 13 (12)
10-06-2021 - A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion
Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M, Boot G, Mackerodt J, Lockley M, Knight MM, Balkwill FR and Pearce OMT
Iscience, Elsevier vol. 24 (6)
29-05-2021 - Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT, Knight MM and Balkwill FR
Iscience, Elsevier vol. 24 (6)
29-05-2021 - Polycystin-2 is required for chondrocyte mechanotransduction and traffics to the primary cilium in response to mechanical stimulation
Thompson C, Mcfie M, Chapple J, BEALES P and Knight M
International Journal of Molecular Sciences, Mdpi Ag
21-04-2021 - Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening.
Wu H, Wang Z, Liu S, Meng H, Shelton JC, Thompson CL, Fu S and Knight MM
Biochem Biophys Res Commun
15-04-2021 - Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD
Frontiers in Bioengineering and Biotechnology, Frontiers vol. 9
18-02-2021 - Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O, Knight M and Balkwill F
, Editors: Balkwill F. Biorxiv.Org
02-02-2021 - Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction
Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson C and Knight M
, Editors: Block JA. Osteoarthritis and Cartilage, Elsevier
01-01-2021
2020
- Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD
Frontiers in Bioengineering and Biotechnology, Frontiers Media Sa vol. 8
10-12-2020 - Solution-Processed Epitaxial Growth of Arbitrary Surface Nanopatterns on Hybrid Perovskite Monocrystalline Thin Films.
Zhang J, Guo Q, Li X, Li C, Wu K, Abrahams I, Yan H, Knight MM, Humphreys CJ and Su L
Acs Nano, American Chemical Society
27-08-2020 - Nanoscale mapping reveals functional differences in ion channels populating the membrane of primary cilia
Torres-Pérez JV, Naeem H, Thompson CL, Knight MM and Novak P
Cellular Physiology and Biochemistry vol. 54 (1), 15-26.
10-01-2020
2019
- Sub-toxic levels of Co2+ are anti-inflammatory and protect cartilage from degradation caused by IL-1β
Fu S, Meng H, Freer F, Kwon J, Shelton JC and Knight MM
Clinical Biomechanics, Elsevier vol. 79
24-12-2019 - Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model
Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM and Norris DP
Nature Communications, Springer Nature vol. 10 (1)
06-09-2019 - Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage
Inamdar SR, Barbieri E, Terrill NJ, Knight MM and Gupta HS
Acta Biomaterialia, Elsevier vol. 97, 437-450.
30-07-2019 - Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression
Delaine-Smith R, Wright N, Hanley C, Hanwell R, Bhome R, Bullock M, Drifka C, Eliceiri K, Thomas G, Knight M, Mirnezami A and Peake N
Cancers, Mdpi Ag
21-05-2019 - Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation
Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 27 (7), 1064-1074.
25-03-2019 - An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation
Harris C, THORPE SD, Rushwan S, Wang W, THOMPSON C, Peacock J, KNIGHT M, Gooptu B and Greenough A
Journal of Biomechanics, Elsevier
22-03-2019 - Oncometabolite induced primary cilia loss in pheochromocytoma
O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM, Sharp TV, Barnes MR, Srirangalingam U, Drake WM and Chapple JP
Endocrine-Related Cancer vol. 26 (1), 165-180.
01-01-2019
2018
- Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6
Rowson DT, Shelton JC, Screen HRC and Knight MM
Scientific Reports, Springer Nature vol. 8 (1)
23-07-2018 - Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages
Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM and Shelton JC
European Cells and Materials vol. 36, 142-155.
01-07-2018 - Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling
Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP and Connelly JT
Journal of Cell Science vol. 131 (10), 215780-215780.
15-05-2018 - Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression.
Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM and Shelton JC
Acta Biomater vol. 72, 434-446.
09-04-2018
2017
- Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers.
Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR
Cancer Discov
01-12-2017 - Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling.
Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP and Knight MM
Eur Cell Mater vol. 34, 128-141.
20-09-2017 - The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage.
Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM and Gupta HS
Acs Nano
11-08-2017 - Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis.
Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA, Chapple JP, Knight MM and Yuan H
Acta Biomater vol. 57, 487-497.
15-07-2017 - Smoothened‐antagonists reverse homogentisic acid‐induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria
Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL, Petricci E, Manetti F, Taddei M, Knight MM and Santucci A
Journal of Cellular Physiology, Wiley vol. 232 (11), 3103-3111.
29-03-2017 - Reduced Primary Cilia Length and Altered Arl13b Expression Are Associated with Deregulated Chondrocyte Hedgehog Signalling in Alkaptonuria
THORPE SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A and Knight MM
Journal of Cellular Physiology, John Wiley & Sons Inc.
03-02-2017
2016
- Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics
Delaine-Smith RM, Burney S, Balkwill FR and Knight MM
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 60, 401-415.
01-07-2016 - Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion
Sliogeryte K, Botto L, Lee DA and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 24 (5), 912-920.
01-05-2016 - Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon.
Rowson D, Knight MM and Screen HRC
J Orthop Res vol. 34 (12), 2146-2153.
23-03-2016 - IFT88 influences chondrocyte actin organization and biomechanics
KNIGHT MM, wang W, wang Z, wann A, thompson C and hassen A
Osteoarthritis and Cartilage
01-03-2016 - Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling
Thompson CL, Wiles A, Poole CA and Knight MM
Faseb Journal vol. 30 (2), 716-726.
01-02-2016 - Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration
Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N and Knight MM
Journal of Biomechanics, Elsevier vol. 49 (2), 310-317.
25-01-2016
2015
- Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β
Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP and Knight MM
Arthritis Research & Therapy vol. 17 (1)
24-12-2015 - Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult.
Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL and Hung CT
Arthritis Res Ther vol. 17, 361-361.
14-12-2015 - Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling
Thompson CL, Poole CA and Knight MM
The Faseb Journal, Federation of American Society of Experimental Biology vol. 100 (4), A39-A40.
23-10-2015 - FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD
CHEN J, BADER DL, LEE DA and KNIGHT MM
Journal of Mechanics in Medicine and Biology, World Scientific Publishing vol. 15 (05)
01-10-2015