Prof Martin Knight
BEng, MSc, PhD, FHEA

 

Key Publications

  • Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR and Knight MM (2023). A Novel Primary Cilium-Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells. Advanced Science 
    01-01-2023
  • Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N and Knight MM (2022). YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression. Elsevier  Osteoarthritis and Cartilage  vol. 31, (5) 600-612.
    08-11-2022
  • Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM (2021). Mechanical stimulation modulates osteocyte regulation of cancer cell phenotype. Cancers  vol. 13, (12)
    02-06-2021
  • Thompson C, Mcfie M, Chapple J, BEALES P and Knight M (2021). Polycystin-2 is required for chondrocyte mechanotransduction and traffics to the primary cilium in response to mechanical stimulation. Mdpi Ag  International Journal of Molecular Sciences 
    21-04-2021
  • Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR (2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov 
    01-12-2017

All Publications

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    2023

    2022

    • Hayward MK, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF and Jones JL (2022). Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion. Npj Breast Cancer vol. 8 (1)
      01-12-2022
    • Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N and Knight MM (2022). YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression. Elsevier  Osteoarthritis and Cartilage vol. 31 (5), 600-612.
      08-11-2022
    • Badar W, Ali H, Brooker ON, Newham E, Snow T, Terrill NJ, Tozzi G, Fratzl P, Knight MM and Gupta HS (2022). Collagen pre-strain discontinuity at the bone—Cartilage interface. Plos One vol. 17 (9 September)
      01-09-2022
    • Heywood HK, Gardner L, Knight MM and Lee DA (2022). Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems. Springer Nature  In Vitro Models, 1-8.
      31-08-2022

    2021

    • Inamdar SR, Prévost S, Terrill NJ, Knight MM and Gupta HS (2021). Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage. Elsevier  Acta Biomaterialia vol. 136, 314-326.
      24-11-2021
    • Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M, Boot G, Mackerodt J, Lockley M, Knight MM, Balkwill FR and Pearce OMT (2021). A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion. Iscience vol. 24 (6)
      25-06-2021
    • Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT, Knight MM and Balkwill FR (2021). Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer. Iscience vol. 24 (6)
      25-06-2021
    • Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM (2021). Mechanical stimulation modulates osteocyte regulation of cancer cell phenotype. Cancers vol. 13 (12)
      02-06-2021
    • Thompson C, Mcfie M, Chapple J, BEALES P and Knight M (2021). Polycystin-2 is required for chondrocyte mechanotransduction and traffics to the primary cilium in response to mechanical stimulation. Mdpi Ag  International Journal of Molecular Sciences
      21-04-2021
    • Wu H, Wang Z, Liu S, Meng H, Shelton JC, Thompson CL, Fu S and Knight MM (2021). Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening. Biochem Biophys Res Commun
      15-04-2021
    • Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD (2021). Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models (Front. Bioeng. Biotechnol., (2020), 8, 602646, 10.3389/fbioe.2020.602646). Frontiers in Bioengineering and Biotechnology vol. 9
      18-02-2021
    • Delaine-Smith R, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones R, Lecker L, Pearce O, Knight M and Balkwill F (2021). Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer., Editors: Balkwill F. Biorxiv.Org
      02-02-2021
    • Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson C and Knight M (2021). Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction., Editors: Block JA. Elsevier  Osteoarthritis and Cartilage
      01-01-2021

    2020

    • Thompson CL, Fu S, Heywood HK, Knight MM and Thorpe SD (2020). Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models. Frontiers Media Sa  Frontiers in Bioengineering and Biotechnology vol. 8
      10-12-2020
    • Fu S, Meng H, Freer F, Kwon J, Shelton JC and Knight MM (2020). Sub-toxic levels of Co2+ are anti-inflammatory and protect cartilage from degradation caused by IL-1β. Clinical Biomechanics vol. 79
      01-10-2020
    • Zhang J, Guo Q, Li X, Li C, Wu K, Abrahams I, Yan H, Knight MM, Humphreys CJ and Su L (2020). Solution-Processed Epitaxial Growth of Arbitrary Surface Nanopatterns on Hybrid Perovskite Monocrystalline Thin Films. American Chemical Society  Acs Nano
      27-08-2020
    • Torres-Pérez JV, Naeem H, Thompson CL, Knight MM and Novak P (2020). Nanoscale mapping reveals functional differences in ion channels populating the membrane of primary cilia. Cellular Physiology and Biochemistry vol. 54 (1), 15-26.
      10-01-2020

    2019

    • Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM and Norris DP (2019). Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model. Nature Communications vol. 10 (1)
      01-12-2019
    • Inamdar SR, Barbieri E, Terrill NJ, Knight MM and Gupta HS (2019). Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage. Elsevier  Acta Biomaterialia vol. 97, 437-450.
      30-07-2019
    • Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT and Knight MM (2019). Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation. Osteoarthritis and Cartilage vol. 27 (7), 1064-1074.
      01-07-2019
    • Delaine-Smith R, Wright N, Hanley C, Hanwell R, Bhome R, Bullock M, Drifka C, Eliceiri K, Thomas G, Knight M, Mirnezami A and Peake N (2019). Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression. Mdpi Ag  Cancers
      21-05-2019
    • Harris C, THORPE SD, Rushwan S, Wang W, THOMPSON C, Peacock J, KNIGHT M, Gooptu B and Greenough A (2019). An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation. Elsevier  Journal of Biomechanics
      22-03-2019
    • O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM, Sharp TV, Barnes MR, Srirangalingam U, Drake WM and Chapple JP (2019). Oncometabolite induced primary cilia loss in pheochromocytoma. Endocrine-Related Cancer vol. 26 (1), 165-180.
      01-01-2019

    2018

    • Rowson DT, Shelton JC, Screen HRC and Knight MM (2018). Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6. Scientific Reports vol. 8 (1)
      01-12-2018
    • Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM and Shelton JC (2018). Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages. European Cells and Materials vol. 36, 142-155.
      01-07-2018
    • Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP and Connelly JT (2018). Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling. Journal of Cell Science vol. 131 (10), 215780-215780.
      15-05-2018
    • Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM and Shelton JC (2018). Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression. Acta Biomater vol. 72, 434-446.
      09-04-2018

    2017

    • Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR (2017). Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers. Cancer Discov
      01-12-2017
    • Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL, Petricci E, Manetti F, Taddei M, Knight MM and Santucci A (2017). Smoothened-antagonists reverse homogentisic acid-induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria. Journal of Cellular Physiology vol. 232 (11), 3103-3111.
      01-11-2017
    • Thompson CL, Plant JC, Wann AK, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP and Knight MM (2017). Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling. Eur Cell Mater vol. 34, 128-141.
      20-09-2017
    • Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM and Gupta HS (2017). The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization During Physiological Loading of Cartilage. Acs Nano
      11-08-2017
    • Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA, Chapple JP, Knight MM and Yuan H (2017). Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis. Acta Biomater vol. 57, 487-497.
      15-07-2017
    • THORPE SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A and Knight MM (2017). Reduced Primary Cilia Length and Altered Arl13b Expression Are Associated with Deregulated Chondrocyte Hedgehog Signalling in Alkaptonuria. John Wiley & Sons Inc.  Journal of Cellular Physiology
      03-02-2017

    2016

    • Delaine-Smith RM, Burney S, Balkwill FR and Knight MM (2016). Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics. Elsevier  Journal of The Mechanical Behavior of Biomedical Materials vol. 60, 401-415.
      01-07-2016
    • Sliogeryte K, Botto L, Lee DA and Knight MM (2016). Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion. Elsevier  Osteoarthritis and Cartilage vol. 24 (5), 912-920.
      01-05-2016
    • Rowson D, Knight MM and Screen HRC (2016). Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon. J Orthop Res vol. 34 (12), 2146-2153.
      23-03-2016
    • KNIGHT MM, wang W, wang Z, wann A, thompson C and hassen A (2016). IFT88 influences chondrocyte actin organization and biomechanics. Osteoarthritis and Cartilage
      01-03-2016
    • Thompson CL, Wiles A, Poole CA and Knight MM (2016). Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. Faseb Journal vol. 30 (2), 716-726.
      01-02-2016
    • Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N and Knight MM (2016). Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration. Elsevier  Journal of Biomechanics vol. 49 (2), 310-317.
      25-01-2016
    • Knight M, Buchholz N and Bourdoumis A (2016). Physiology of urethral flow. In Handbook of Urinary Stents: Basic Science and Clinical Applications  Jaypee Brothers Medical Publishing  219-219.
      01-01-2016

    2015

    • Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP and Knight MM (2015). Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β. Arthritis Research & Therapy vol. 17 (1)
      24-12-2015
    • Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL and Hung CT (2015). Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult. Arthritis Res Ther vol. 17, 361-361.
      14-12-2015
    • Thompson CL, Poole CA and Knight MM (2015). Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling. Federation of American Society of Experimental Biology  The Faseb Journal vol. 100 (4), A39-A40.
      23-10-2015
    • Chen J, Bader DL, Lee DA and Knight MM (2015). FINITE ELEMENT ANALYSIS of MECHANICAL DEFORMATION of CHONDROCYTE to 2D SUBSTRATE and 3D SCAFFOLD. Journal of Mechanics in Medicine and Biology vol. 15 (5)
      01-10-2015
    • KNIGHT MM, Thompson CL, Yasmin H, Varone A, Wiles A and Poole CA (2015). Lithium chloride prevents interleukin- 1β induced cartilage degradation and loss of mechanical properties. Wiley: 12 Months  Journal of Orthopaedic Research
      01-10-2015
    • Dalbay MT, Thorpe SD, Connelly JT, Chapple JP and Knight MM (2015). Adipogenic differentiation of hMSCs is mediated by recruitment of IGF-1r onto the primary cilium associated with cilia elongation. Stem Cells vol. 33 (6), 1952-1961.
      01-06-2015

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