Prof Martin Knight
BEng, MSc, PhD, FHEA
Research Group Members
Prof Knight has a large multidisciplinary research group with expertise including biomedical engineering, biomechanics, cell biology, organ-on-a-chip technology, cancer and musculoskeletal disease. We are actively seeking collaboration with externally funded research fellows and PhD students.
Research Assistants
 GROSSEMY, Simon |  HOPKINS, Timothy |  MUñOZ CASTRO, Natalia | AGRAWAL, Ayushi |
Current PhD Projects
| Thesis Title |
|---|
| Biophysical biomarkers to characterize cancer-associated fibroblasts in breast cancer |
| Development of a Polycystic Kidney Disease organ-chip model to study therapeutic regulation of primary cilia mechanobiology |
| Development of an arterial organ-chip to study the role of primary cilia in atherosclerosis |
| Development of an Organ-chip Model to examine Muscle Degeneration |
| Development of organ-chip models of the growth plate with mechanical stimulation |
| Exploring tendon health and disease with tendon-on-a-chip models |
| Investigating the influence of synovium on cartilage response to inflammatory stimuli using predictive invitro models. |
| Long-term Tracking and Targeted Therapy of Mesenchymal Stem Cell Labeled Nanoparticles |
| Nanoscale damage markers for early osteoarthritis detection in the bone-cartilage unit |
| Novel Models of Tendinopathy on a Chip |
| The interfascicular matrix niche ? novel approaches to identify the aetiology of tendinopathy |
Past PhD Projects
| Thesis Title | Year |
|---|---|
| A Single Cell Analysis Approach for Viscoelastic Characterization Using Microfluidics. | 2023 |
| The role of YAP and primary cilia in regulating inflammatory responses of cartilage | 2023 |
| High throughput confocal screen of 1727 compounds to identify novel regulators of primary cilia structure | 2022 |
| Synthesis of hybrid perovskite single crystals and study of their optoelectronic and photonic properties with nano/microstructures | 2021 |
| The role of phosphorylation Ezrin in regulating the relationship between biophysical properties and cell migration | 2020 |
| Mircrofluidic-based Model of the Microvasculature to Study the Impact of Glycocalyx on Angiogenesis | 2019 |
| The role of primary cilia in the anti-inflammatory effects of mechanical loading in cartilage cells. | 2019 |
| Nanoscale mechanics of collagen in articular cartilage | 2018 |
| The effects of cobalt and chromium ions and nanoparticles on macrophage and fibroblast behaviour | 2018 |
| The role of primary cilia in tendinopathy | 2018 |
| Roles of primary cilia in hMSC in differentiation | 2016 |
| The effects of the rate of hypo-osmotic challenge and IFT88 mutation on the biomechanics of chondrocytes. | 2016 |
| Mechanical properties of stem cells using micropipette aspiration | 2015 |
| Accelerated wear protocols for understanding clinical wear in modern hip prostheses | 2014 |
| Interaction between primary cilia length and hedgehog signalling in response to mechanical and thermal stress | 2013 |
| Nuclear Related Responses to Osmotic Challenge in Chondrocytes | 2013 |
| Viscoelastic Response of Cells and the Role of Actin Cytoskeletal Remodelling | 2012 |
| Development of a non-invasive method to detect pericellular spatial oxygen gradients using FLIM | 2011 |
| The potential of pulsed low-intensity ultrasound to stimulate chondrocytes in a 3D model system | 2009 |
| Calcium mediated signalling pathways for chondrocytes in 3D constructs subjected to cyclic loading | 2006 |
| Modulation of the effect of tensile strain on fibroblasts by extracellular matrix molecules and serum | 2006 |