Prof Martin Knight
BEng, MSc, PhD, FHEA


Research Group Members

Prof Knight has a large multidisciplinary research group with expertise including biomedical engineering, biomechanics, cell biology, organ-on-a-chip technology, cancer and musculoskeletal disease. The group includes multiple post docs and PhD students. We also have a strong track record of hosting research fellows funded via various routes including EU Marie Curie Fellowships, Versus Arthritis Fellowships, etc.

Please contact Martin if you are applying for funding and are interested in joining the group as either a post doc or PhD student.

Research Assistants

Dr Grossemy
Dr Hopkins
HOPKINS, Timothy
Prof Knight

Current PhD Projects

Thesis Title
Development of a Polycystic Kidney Disease organ-chip model to study therapeutic regulation of primary cilia mechanobiology
Development of an arterial organ-chip to study the role of primary cilia in atherosclerosis
Development of an Organ-chip Model to examine Muscle Degeneration
Development of organ-chip models of the growth plate with mechanical stimulation
Exploring tendon health and disease with tendon-on-a-chip models
Investigating the influence of synovium on cartilage response to inflammatory stimuli using predictive invitro models.
Long-term Tracking and Targeted Therapy of Mesenchymal Stem Cell Labeled Nanoparticles
Long-term Tracking and Targeted Therapy of Mesenchymal Stem Cell Labeled Nanoparticles
Mechanical, inflammatory, and pharmaceutical regulation of cell polarity and the role of primary cilia in a human kidney-organ chip model
Nanoscale damage markers for early osteoarthritis detection in the bone-cartilage unit
Novel Models of Tendinopathy on a Chip
The interfascicular matrix niche ? novel approaches to identify the aetiology of tendinopathy

Past PhD Projects

Thesis TitleYear
A Single Cell Analysis Approach for Viscoelastic Characterization Using Microfluidics.2023
Biophysical biomarkers to characterize cancer-associated fibroblasts in breast cancer2023
The role of YAP and primary cilia in regulating inflammatory responses of cartilage2023
High throughput confocal screen of 1727 compounds to identify novel regulators of primary cilia structure2022
Synthesis of hybrid perovskite single crystals and study of their optoelectronic and photonic properties with nano/microstructures2021
The role of phosphorylation Ezrin in regulating the relationship between biophysical properties and cell migration2020
Mircrofluidic-based Model of the Microvasculature to Study the Impact of Glycocalyx on Angiogenesis2019
The role of primary cilia in the anti-inflammatory effects of mechanical loading in cartilage cells.2019
Nanoscale mechanics of collagen in articular cartilage2018
The effects of cobalt and chromium ions and nanoparticles on macrophage and fibroblast behaviour2018
The role of primary cilia in tendinopathy2018
Roles of primary cilia in hMSC in differentiation2016
The effects of the rate of hypo-osmotic challenge and IFT88 mutation on the biomechanics of chondrocytes.2016
Mechanical properties of stem cells using micropipette aspiration2015
Accelerated wear protocols for understanding clinical wear in modern hip prostheses2014
Interaction between primary cilia length and hedgehog signalling in response to mechanical and thermal stress2013
Nuclear Related Responses to Osmotic Challenge in Chondrocytes2013
Viscoelastic Response of Cells and the Role of Actin Cytoskeletal Remodelling2012
Development of a non-invasive method to detect pericellular spatial oxygen gradients using FLIM2011
The potential of pulsed low-intensity ultrasound to stimulate chondrocytes in a 3D model system2009
Calcium mediated signalling pathways for chondrocytes in 3D constructs subjected to cyclic loading2006
Modulation of the effect of tensile strain on fibroblasts by extracellular matrix molecules and serum2006