Prof Martin Knight
BEng, MSc, PhD, FHEA


Research Group Members

Prof Knight has a large multidisciplinary research group with expertise including biomedical engineering, biomechanics, cell biology, organ-on-a-chip technology, cancer and musculoskeletal disease. We are actively seeking collaboration with externally funded research fellows and PhD students.

Research Assistants

Dr Heywood
Dr Thompson
Prof Knight
Dr Inamdar
INAMDAR, Sheetal
Dr Nolan
NOLAN, Joanne
Dr Hopkins
HOPKINS, Timothy

Current PhD Projects

Thesis Title
Biophysical biomarkers to characterize cancer-associated fibroblasts in drug screening strategies.
Development of a Polycystic Kidney Disease organ-chip model to study therapeutic regulation of primary cilia mechanobiology
Development of an arterial organ-chip to study the role of primary cilia in atherosclerosis
High throughput confocal screen of 1727 compounds to identify novel regulators of primary cilia structure
Microfluidics for sorting circulating tumor cells
Nanoscale damage markers for early osteoarthritis detection in the bone-cartilage unit
Novel Models of Tendinopathy on a Chip
Organ-on-a-chip model of cartilage disease
The effect of substrate stiffness on primary cilia and regulation of the tumour microenvironment.
The interfascicular matrix niche ? novel approaches to identify the aetiology of tendinopathy

Past PhD Projects

Thesis TitleYear
Synthesis of hybrid perovskite single crystals and study of their optoelectronic and photonic properties with nano/microstructures2021
The role of phosphorylation Ezrin in regulating the relationship between biophysical properties and cell migration2020
Mircrofluidic-based Model of the Microvasculature to Study the Impact of Glycocalyx on Angiogenesis2019
The role of primary cilia in the anti-inflammatory effects of mechanical loading in cartilage cells.2019
Nanoscale mechanics of collagen in articular cartilage2018
The effects of cobalt and chromium ions and nanoparticles on macrophage and fibroblast behaviour2018
The role of primary cilia in tendinopathy2018
Roles of primary cilia in hMSC in differentiation2016
The effects of the rate of hypo-osmotic challenge and IFT88 mutation on the biomechanics of chondrocytes.2016
Mechanical properties of stem cells using micropipette aspiration2015
Accelerated wear protocols for understanding clinical wear in modern hip prostheses2014
Interaction between primary cilia length and hedgehog signalling in response to mechanical and thermal stress2013
Nuclear Related Responses to Osmotic Challenge in Chondrocytes2013
Viscoelastic Response of Cells and the Role of Actin Cytoskeletal Remodelling2012
Development of a non-invasive method to detect pericellular spatial oxygen gradients using FLIM2011
The potential of pulsed low-intensity ultrasound to stimulate chondrocytes in a 3D model system2009
Calcium mediated signalling pathways for chondrocytes in 3D constructs subjected to cyclic loading2006
Modulation of the effect of tensile strain on fibroblasts by extracellular matrix molecules and serum2006