Prof David Lee
BSc (Hons), MA, PhD
All Publications
Page 1 of 5
2022
- Modulation of sirtuins during monolayer chondrocyte culture influences cartilage regeneration upon transfer to a 3D culture environment
Heywood HK, Thorpe SD, Jeropoulos RM, Caton PW and Lee DA
Frontiers in Bioengineering and Biotechnology, Frontiers Media vol. 10
06-12-2022 - Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems
Heywood HK, Gardner L, Knight MM and Lee DA
In Vitro Models, Springer Nature, 1-8.
31-08-2022 - Covariation of Pluripotency Markers and Biomechanical Properties in Mouse Embryonic Stem Cells
Brookes O, Thorpe SD, Evans OR, Keeling MC and Lee DA
Frontiers in Cell and Developmental Biology, Frontiers vol. 10
16-05-2022
2021
- G Protein-Coupled Estrogen Receptor Regulates Actin Cytoskeleton Dynamics to Impair Cell Polarization
Lachowski D, Cortes E, Matellan C, Rice A, Lee DA, Thorpe SD and del Río Hernández AE
Frontiers in Cell and Developmental Biology, Frontiers Media vol. 8, 592628-592628.
22-01-2021
2020
- GPER activation inhibits cancer cell mechanotransduction and basement membrane invasion via RhoA
Rice A, Cortes E, Lachowski D, Oertle P, Matellan C, Thorpe SD, Ghose R, Wang H, Lee DA, Plodinec M and Del Río Hernández AE
Cancers, Mdpi Ag vol. 12 (2)
25-01-2020 - Syndecan-4 tunes cell mechanics by activating the kindlin-integrin-RhoA pathway
Thorpe S, Chronopoulos A, Cortes E, Lachowski D, Rice A, Mykuliak V, Róg T, Lee D, Hytonen V and del Río Hernández A
Nature Materials, Nature Research
06-01-2020
2018
- Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor
Cortes E, Lachowski D, Rice A, THORPE SD, Robinson B, Yeldag G, LEE DA, Ghemtio L, Rombouts K and del Río Hernández AE
Oncogene, Springer Nature [Academic Journals On Nature.Com]
21-12-2018 - Tamoxifen mechanically reprograms the tumor microenvironment via HIF‐1A and reduces cancer cell survival
Cortes E, Lachowski D, Robinson B, Sarper M, Teppo JS, Thorpe SD, Lieberthal TJ, Iwamoto K, Lee DA, Okada‐Hatakeyama M, Varjosalo MT and del Río Hernández AE
Embo Reports, Springer Nature vol. 20 (1)
12-12-2018 - GPER is a mechanoregulator of pancreatic stellate cells and the tumor microenvironment
Cortes E, Sarper M, Robinson B, Lachowski D, Chronopoulos A, Thorpe SD, Lee DA and del Río Hernández AE
Embo Reports, Springer Nature vol. 20 (1)
11-12-2018 - RAR‐β is downregulated in HCC & cirrhosis and its expression inhibits myosin‐driven activation and durotaxis in hepatic stellate cells
Cortes E, Lachowski D, Rice A, Chronopoulos A, Robinson B, THORPE SD, LEE DA, Possamai LA, Wang H, Pinato DJ and del Rio Hernández AE
Hepatology, Wiley
28-07-2018
2017
- Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification
Elyasigomari V, Lee DA, Screen HRC and SHAHEED MH
Journal of Biomedical Informatics vol. 67 (2017), 11-20.
03-02-2017 - Dynamic regulation of nuclear architecture and mechanics—a rheostatic role for the nucleus in tailoring cellular mechanosensitivity
THORPE SD and Lee DA
Nucleus, Taylor & Francis vol. 8 (3), 287-300.
02-02-2017
2016
- Differentiation alters stem cell nuclear architecture, mechanics, and mechano-sensitivity.
Heo S-J, Driscoll TP, Thorpe SD, Nerurkar NL, Baker BM, Yang MT, Chen CS, Lee DA and Mauck RL
Elife, Elife Sciences Publications Ltd vol. 5
30-11-2016 - Oxygen tension modulates the effects of TNFα in compressed chondrocytes.
Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL and Chowdhury TT
Inflamm Res
22-09-2016 - Mechanically Induced Chromatin Condensation Requires Cellular Contractility in Mesenchymal Stem Cells
Heo SJ, Han WM, Szczesny SE, Cosgrove BD, Elliott DM, Lee DA, Duncan RL and Mauck RL
Biophysical Journal vol. 111 (4), 864-874.
23-08-2016 - Bioenergetic reprogramming of articular chondrocytes by exposure to exogenous and endogenous reactive oxygen species and its role in the anabolic response to low oxygen
Heywood HK and Lee DA
Journal of Tissue Engineering and Regenerative Medicine vol. 11 (8), 2286-2294.
22-06-2016 - Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion
Sliogeryte K, Botto L, Lee DA and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 24 (5), 912-920.
01-05-2016 - States rights and Australia’s adoption of the statute of Westminster, 1931–1942
Lee D
History Australia, Taylor & Francis vol. 13 (2), 258-274.
02-04-2016 - Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility
Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT
Journal of Investigative Dermatology, Elsevier vol. 136 (1), 74-83.
01-01-2016 - Type VI Collagen Regulates Dermal Matrix Assembly and Fibroblast Motility.
Theocharidis G, Drymoussi Z, Kao AP, Barber AH, Lee DA, Braun KM and Connelly JT
J Invest Dermatol vol. 136 (1), 74-83.
01-01-2016
2015
- Biophysical Regulation of Chromatin Architecture Instills a Mechanical Memory in Mesenchymal Stem Cells
Heo S-J, Thorpe SD, Driscoll TP, Duncan RL, Lee DA and Mauck RL
Scientific Reports, Springer Nature vol. 5 (1)
23-11-2015 - FINITE ELEMENT ANALYSIS OF MECHANICAL DEFORMATION OF CHONDROCYTE TO 2D SUBSTRATE AND 3D SCAFFOLD
CHEN J, BADER DL, LEE DA and KNIGHT MM
Journal of Mechanics in Medicine and Biology, World Scientific Publishing vol. 15 (05)
01-10-2015
2014
- Stem cell differentiation increases membrane-actin adhesion regulating cell blebability, migration and mechanics
Sliogeryte K, Thorpe SD, Lee DA, Botto L and Knight MM
Scientific Reports, Springer Nature vol. 4 (1)
04-12-2014 - Quantification of chromatin condensation level by image processing.
Irianto J, Lee DA and Knight MM
Med Eng Phys vol. 36 (3), 412-417.
01-03-2014 - Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture.
Heywood HK, Nalesso G, Lee DA and Dell'accio F
Biores Open Access vol. 3 (1), 9-18.
01-02-2014
2013
- Osmotic challenge drives rapid and reversible chromatin condensation in chondrocytes.
Irianto J, Swift J, Martins RP, McPhail GD, Knight MM, Discher DE and Lee DA
Biophys J vol. 104 (4), 759-769.
19-02-2013 - Continuous and Uninterrupted Oxygen Tension Influences the Colony Formation and Oxidative Metabolism of Human Mesenchymal Stem Cells
Pattappa G, Thorpe SD, Jegard NC, Heywood HK, de Bruijn JD and Lee DA
Tissue Engineering Part C-Methods vol. 19 (1)
01-01-2013 - Reluctant relaxation
Lee D
History Australia, Taylor & Francis vol. 10 (3), 149-170.
01-01-2013
2012
- New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures
Sillitoe I, Cuff AL, Dessailly BH, Dawson NL, Furnham N, Lee D, Lees JG, Lewis TE, Studer RA, Rentzsch R, Yeats C, Thornton JM and Orengo CA
Nucleic Acids Research, Oxford University Press (Oup) vol. 41 (D1), d490-d498.
29-11-2012 - Cell mechanics, structure, and function are regulated by the stiffness of the three-dimensional microenvironment.
Chen J, Irianto J, Inamdar S, Pravincumar P, Lee DA, Bader DL and Knight MM
Biophys J vol. 103 (6), 1188-1197.
19-09-2012 - Dynamic compressive strain influences chondrogenic gene expression in human periosteal cells: a case study.
Bonzani IC, Campbell JJ, Knight MM, Williams A, Lee DA, Bader DL and Stevens MM
J Mech Behav Biomed Mater vol. 11, 72-81.
01-07-2012 - The attachment of intrinsic and extrinsic, mobilized and immobilized adhesion cells to collagen and fibronectin
Branford OA, Lee DA, Rolfe KJ and Grobbelaar AO
Journal of Hand Surgery: European Volume vol. 37 (6), 564-572.
01-07-2012 - The mechanics of flexor tendon adhesions
Branford OA, Lee DA, Bader DL and Grobbelaar AO
Journal of Hand Surgery: European Volume vol. 37 (6), 555-563.
01-07-2012 - Improving metabolic flux predictions using absolute gene expression data
Lee D, Smallbone K, Dunn WB, Murabito E, Winder CL, Kell DB, Mendes P and Swainston N
Bmc Systems Biology, Springer Nature vol. 6 (1)
19-06-2012 - Stanley Melbourne Bruce in London, 1938–41
Lee D
The Journal of Imperial & Commonwealth History, Taylor & Francis vol. 40 (1), 45-65.
01-03-2012 - Scaling and mesostructure of Carbopol dispersions
Gutowski IA, Lee D, de Bruyn JR and Frisken BJ
Rheologica Acta, Springer Nature vol. 51 (5), 441-450.
18-01-2012 - Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading
Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA
Biomechanics and Modeling in Mechanobiology vol. 11 (3-4), 439-447.
01-01-2012 - Mechanical regulation of nuclear structure and function.
Martins RP, Finan JD, Guilak F and Lee DA
Annu Rev Biomed Eng vol. 14, 431-455.
01-01-2012 - Single photon counting fluorescence lifetime detection of pericellular oxygen concentrations.
Hosny NA, Lee DA and Knight MM
J Biomed Opt vol. 17 (1)
01-01-2012
2011
- White Globules in Melanocytic Neoplasms: In Vivo and Ex Vivo Characteristics
Jaimes N, Scope A, Welzel J, Wang KX, Lee DA, Siegel DM and Marghoob AA
Dermatologic Surgery, Wolters Kluwer vol. 38 (1), 128-132.
31-10-2011 - The metabolism of human mesenchymal stem cells during proliferation and differentiation.
Pattappa G, Heywood HK, de Bruijn JD and Lee DA
J Cell Physiol vol. 226 (10), 2562-2570.
01-10-2011 - Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment.
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC
Proc Inst Mech Eng H vol. 225 (8), 821-830.
01-08-2011 - Extensive oral herpes simplex virus type 1 infection in a haematopoietic stem cell transplant recipient not responding to aciclovir
Moses SE, Osborne W, Valappil M, Collin M, Lee D, Waugh S, Jackson G, Parry CM and Crowley B
Journal of Clinical Virology, Elsevier vol. 52 (2), 67-69.
14-06-2011 - Investigating the microstructure of a yield-stress fluid by light scattering
Lee D, Gutowski IA, Bailey AE, Rubatat L, de Bruyn JR and Frisken BJ
Physical Review E, American Physical Society (Aps) vol. 83 (3)
01-03-2011 - 1,000 structures and more from the MCSG
Lee D, de Beer TA, Laskowski RA, Thornton JM and Orengo CA
Bmc Molecular and Cell Biology, Springer Nature vol. 11 (1)
01-01-2011 - Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment
Lewinsohn AD, Anssari-Benham A, Lee DA, Taylor PM, Chester AH, Yacoub MH and Screen HRC
P I Mech Eng H vol. 225 (H8), 821-830.
01-01-2011 - Electrospray deposited fibronectin retains the ability to promote cell adhesion
Martyn SV, Heywood HK, Rockett P, Paine MD, Wang MJ, Dobson PJ, Sheard SJ, Lee DA and Stark JPW
Journal of Biomedical Materials Research - Part B Applied Biomaterials vol. 96 B (1), 110-118.
01-01-2011 - Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading
Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA
Biomechanics and Modeling in Mechanobiology, 1-9.
01-01-2011 - Novel devices for diagnosis and treatment.
Lee DA and Siegel DM
Journal of Drugs in Dermatology vol. 10 (1), 21-22.
01-01-2011 - Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs.
Lee DA, Brand J, Salter D, Akanji O-O and Chowdhury TT
Methods Mol Biol vol. 695, 77-97.
01-01-2011