Prof Thomas Iskratsch
Dipl.-Ing. (Equiv. to MSc/MEng), PhD


Research Funding

On this page:

Current Funded Research Projects

The role of novel mechanosensitive complex in cardiomyocyte pathophysiology

Funding source: BHF British Heart Foundation
Start: 01-10-2024  /  End: 30-09-2027
Amount: £285,532

Talin dependent mechanical imprinting as driver for cardiac disease progression

Funding source: BHF British Heart Foundation
Start: 08-01-2024  /  End: 07-01-2027
Amount: £718,167

Current PhD Studentship Projects

Thermochemical patterning to generate Bionanoarrays

Funding source: Heidelberg Instruments Nano AG
Start: 18-01-2024  /  End: 17-01-2027

Virtual Atria with Personalised Electrophysiology for Atrial Fibrillation Therapy Planning - SEMS Industry-supported PhD Studentship

Funding source: Acutus Medical UK Ltd
Start: 01-10-2022  /  End: 30-09-2025

Development of functional 3D eccrine sweat gland model

Funding source: Unilever UK Ltd
Start: 04-10-2021  /  End: 03-10-2024

Development of functional 3D eccrine sweat gland model


Funding source: Fondazione Dompé
Start: 01-07-2021  /  End: 30-06-2024

Previous Funded Research Projects

The regulation of mechanosensing in healthy and atherosclerotic VSMC

Funding source: BHF British Heart Foundation
Start: 01-12-2020  /  End: 30-11-2023

Vascular smooth muscle cellsplay a central role in the onset and progression of many cardiovascular diseases, from atherosclerosis to vascular injury, where their migration, matrix secretion, or degradation functions are deregulated. Here we are investigating how the phenotypic switch is regulated through physical/mechanical stimuli.

3D Photoelectrochemical Imaging in Porous Light-Addressable Structures

Funding source: EPSRC Engineering and Physical Sciences Research Council
Start: 04-01-2021  /  End: 30-04-2023

The project aims to develop a photoelectrochemical imaging system for mapping of electrochemical processes in three dimensions within porous electrode structures. The new technology will aid the development of novel electrode materials for energy harvesting devices and be suitable for in-situ 3D functional imaging in 3D tissue culture.

Investigating the cardiomyocyte rigidity sensing mechanism with micro patterned surfaces and nanopil

Funding source: BBSRC Biotechnology and Biological Sciences Research Council
Start: 01-02-2019  /  End: 31-03-2023

The composition and the stiffness of the cardiac extracellular matrix change during development or in heart disease. Cardiomyocytes and their progenitors sense these changes, which decides over Cardiomyocyte fate. Our preliminary data suggested a cardiomyocyte specific rigidity sensing mechanism which we will investigate here in detail.

Mechano-regulation of myofibril formation and cardiac remodelling

Funding source: British Heart Foundation
Start: 01-01-2015  /  End: 31-12-2018

While chemical cues have well-established roles in guiding cell differentiation, there is growing evidence of a role for mechanical stimuli, such as matrix rigidity during heart development and disease. However, the mechanisms that underlie this mechanical signalling remain elusive. Here we will study this by combining cell biology, biophysics and nanotechnology in a three-tiered approach in which we examine the cardiomyocyte response to A) passive resistance and varying rigidity; B) active force; C) no force. Detailed understanding will lead to novel and valuable insights into mechanisms of cardiac mechanosensing and could result in novel or improved therapeutic strategies for cardiac diseases.