Prof Thomas Iskratsch
Dipl.-Ing. (Equiv. to MSc/MEng), PhD
Key Publications
- Faleeva M, Ahmad S, Theofilatos K, Lynham S, Watson G, Whitehead M, Marhuenda E, Iskratsch T, Cox S and Shanahan CM (2024). Sox9 Accelerates Vascular Ageing by Regulating Extracellular Matrix Composition and Stiffness. American Heart Association: Circulation Research
05-01-2024 - Iskratsch T, Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D and Shanahan C (2023). Hypertensive pressure mechanosensing alone triggers lipid droplet accumulation and transdifferentiation of vascular smooth muscle cells to foam cells. Wiley Open Access: Advanced Science
25-12-2023 - Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones GE, Yu C-H and Iskratsch T (2022). Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching. Science Advances vol. 8 (15)
01-04-2022 - (2020). Cell scientist to watch – Thomas Iskratsch. The Company of Biologists: Journal of Cell Science vol. 133 (15)
01-08-2020 - Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Dev Cell vol. 44 (3), 326-336.e3.
05-02-2018
All Publications
2024
- Fromager B, Cambedouzou J, Marhuenda E, Iskratsch T, Pinault M, Bakalara N and Cornu D (2024). Tunable electrospun scaffolds of polyacrylonitrile loaded with carbon nanotubes: from synthesis to biological applications. Chembiochem, Wiley
14-02-2024 - Faleeva M, Ahmad S, Theofilatos K, Lynham S, Watson G, Whitehead M, Marhuenda E, Iskratsch T, Cox S and Shanahan CM (2024). Sox9 Accelerates Vascular Ageing by Regulating Extracellular Matrix Composition and Stiffness. Circulation Research, American Heart Association
05-01-2024
2023
- Iskratsch T, Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D and Shanahan C (2023). Hypertensive pressure mechanosensing alone triggers lipid droplet accumulation and transdifferentiation of vascular smooth muscle cells to foam cells. Advanced Science, Wiley Open Access
25-12-2023 - Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D, Prin F, Mohun T, Catibog N, Tapia O, Gerace L, Iskratsch T, Shah AM and Stroud MJ (2023). Lem2 is essential for cardiac development by maintaining nuclear integrity. Cardiovascular Research, Oxford University Press vol. 119 (11), 2074-2088.
17-04-2023 - Swiatlowska P and Iskratsch T (2023). Cardiovascular Mechano-Epigenetics: Force-Dependent Regulation of Histone Modifications and Gene Regulation. Cardiovascular Drugs and Therapy, Springer
18-01-2023 - Battey E, Ross JA, Hoang A, Wilson DGS, Han Y, Levy Y, Pollock RD, Kalakoutis M, Pugh JN, Close GL, Ellison‐Hughes GM, Lazarus NR, Iskratsch T, Harridge SDR, Ochala J and Stroud MJ (2023). Myonuclear alterations associated with exercise are independent of age in humans. The Journal of Physiology, Wiley
04-01-2023
2022
- Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T and Krause S (2022). Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids. Biosensors and Bioelectronics, Elsevier
21-12-2022 - Iskratsch T, Hawkes W, Marhuenda E, Reynolds P, O'Neill C, PANDEY P, Wilson D, FREELEY M, HUANG D, Junquiang H, Gondarenko S, Hone J, Gadegaard N and Palma M (2022). Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM. Philosophical Transactions of The Royal Society B: Biological Sciences, The Royal Society
21-11-2022 - Iskratsch T, Wilson D and Tinker A (2022). The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction. Communications Biology, Nature Research
27-09-2022 - Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones GE, Yu C-H and Iskratsch T (2022). Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching. Science Advances vol. 8 (15)
01-04-2022 - Wilson DGS and Iskratsch T (2022). Factoring in the force: A novel role for eIF6. The Journal of Cell Biology vol. 221 (2)
21-01-2022
2021
- Swiatlowska P and Iskratsch T (2021). Cardiovascular mechanobiology—a Special Issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology and disease. Biophysical Reviews, Springer (Part of Springer Nature) vol. 13 (5), 575-577.
11-09-2021 - Swiatlowska P and Iskratsch T (2021). Tools for studying and modulating (cardiac muscle) cell mechanics and mechanosensing across the scales. Biophysical Reviews, Springer Nature vol. 13 (5), 611-623.
05-09-2021 - Swiatlowska P and Iskratsch T (2021). Announcing the call for the Special Issue on “Cardiovascular mechanobiology—a special issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology, and disease”. Biophysical Reviews, Springer Nature vol. 13 (3), 307-308.
03-05-2021 - Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot JP, Duffau H, Dennis JW, Cornu D and Bakalara N (2021). Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing. Journal of Experimental and Clinical Cancer Research vol. 40 (1)
24-04-2021
2020
- (2020). Cell scientist to watch – Thomas Iskratsch. Journal of Cell Science, The Company of Biologists vol. 133 (15)
01-08-2020
2019
- Di Cio S, Iskratsch T, Connelly JT and Gautrot JE (2019). Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing. Biomaterials, Elsevier vol. 232
16-12-2019 - Xanthis I and Iskratsch T (2019). Lamin-A Mechano-Protects the Heart. Developmental Cell
17-06-2019 - Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T and Hodivala-Dilke K (2019). Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation. Cancer Research, American Association For Cancer Research
12-06-2019 - Sit B, Gutmann D and Iskratsch T (2019). Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing. Journal of Muscle Research and Cell Motility, Springer Nature vol. 40 (2), 197-209.
01-06-2019 - Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T and Palma M (2019). Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control. Faraday Discussions, Royal Society of Chemistry (Rsc)
18-03-2019 - Ward M and Iskratsch T (2019). Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart. Biochimica Et Biophysica Acta (Bba) - Molecular Cell Research, Elsevier vol. 1867 (3)
08-02-2019
2018
- Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, ISKRATSCH T and Lappalainen P (2018). Calponin-3 is critical for coordinated contractility of actin stress fibers. Scientific Reports, Nature Publishing Group
05-12-2018 - Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions. Dev Cell vol. 44 (3), 326-336.e3.
05-02-2018
2017
- Lee NM, Erisken C, Iskratsch T, Sheetz M, Levine WN and Lu HH (2017). Polymer fiber-based models of connective tissue repair and healing. Biomaterials vol. 112, 303-312.
01-01-2017
2016
- Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML and Sheetz MP (2016). Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability. Immunol Cell Biol vol. 94 (10), 981-993.
30-06-2016 - Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N, Tabdanov E, Lohner J, Gondarenko A, Chander AC, Roca-Cusachs P, O'Shaughnessy B, Hone J and Sheetz MP (2016). α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions. Mol Biol Cell vol. 27 (22), 3471-3479.
27-04-2016
2015
- Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B, Hone J and Sheetz MP (2015). Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices. Nat Cell Biol vol. 18 (1), 33-42.
30-11-2015 - Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC and Iskratsch T (2015). Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells. Integr Biol (Camb) vol. 7 (10), 1272-1284.
03-07-2015
2014
- Wolfenson H, Iskratsch T and Sheetz MP (2014). Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events. Biophysical Journal, Elsevier vol. 107 (11), 2508-2514.
01-12-2014 - Iskratsch T, Wolfenson H and Sheetz MP (2014). Appreciating force and shape—the rise of mechanotransduction in cell biology. Nature Reviews. Molecular Cell Biology vol. 15 (12), 825-833.
30-10-2014 - Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG and Ehler E (2014). The formin FHOD1 in cardiomyocytes. Anat Rec (Hoboken) vol. 297 (9), 1560-1570.
14-08-2014 - Zhang X, Moore SW, Iskratsch T and Sheetz MP (2014). N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading. Journal of Cell Science, The Company of Biologists vol. 127 (7), 1394-1405.
01-01-2014
2013
- Iskratsch T, Yu C-H, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E and Sheetz M (2013). FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration. Developmental Cell, Elsevier vol. 27 (5), 545-559.
01-12-2013
2012
- Lynch CD, Lazar AM, Iskratsch T, Zhang X and Sheetz MP (2012). Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions. Molecular Biology of The Cell, American Society For Cell Biology (Ascb) vol. 24 (1), 21-30.
31-10-2012 - Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I and Ehler E (2012). Two distinct phosphorylation events govern the function of muscle FHOD3. Cellular and Molecular Life Sciences, Springer Nature vol. 70 (5), 893-908.
04-10-2012 - Roca-Cusachs P, Iskratsch T and Sheetz MP (2012). Finding the weakest link – exploring integrin-mediated mechanical molecular pathways. Journal of Cell Science, The Company of Biologists vol. 125 (13), 3025-3038.
01-01-2012
2011
- Dwyer J, Iskratsch T and Ehler E (2011). Actin in striated muscle: recent insights into assembly and maintenance. Biophysical Reviews, Springer Nature vol. 4 (1), 17-25.
20-12-2011 - Iskratsch T and Ehler E (2011). Formin-g muscle cytoarchitecture. Bioarchitecture, Taylor & Francis vol. 1 (2), 66-68.
01-03-2011
2010
- Iskratsch T, Lange S, Dwyer J, Kho AL, Remedios CD and Ehler E (2010). Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. The Journal of General Physiology, Rockefeller University Press vol. 137 (1), i1-i1.
27-12-2010 - Iskratsch T, Lange S, Dwyer J, Kho AL, dos Remedios C and Ehler E (2010). Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance. Journal of Cell Biology, Rockefeller University Press vol. 191 (6), 1159-1172.
13-12-2010
2009
- Herbst R, Iskratsch T, Unger E and Bittner RE (2009). Aberrant development of neuromuscular junctions in glycosylation-defective Largemyd mice. Neuromuscular Disorders, Elsevier vol. 19 (5), 366-378.
05-04-2009 - Gutternigg M, Rendić D, Voglauer R, Iskratsch T and Wilson IBH (2009). Mammalian cells contain a second nucleocytoplasmic hexosaminidase. Biochemical Journal, Portland Press vol. 419 (1), 83-90.
13-03-2009
2008
- Iskratsch T, Braun A, Paschinger K and Wilson IBH (2008). Specificity analysis of lectins and antibodies using remodeled glycoproteins. Analytical Biochemistry, Elsevier vol. 386 (2), 133-146.
14-12-2008