Dr Thomas Iskratsch
Dipl.-Ing. (Equiv. to MSc/MEng), PhD

 

Key Publications

  • Iskratsch T, Hawkes W, Marhuenda E, Reynolds P, O'Neill C, PANDEY P, Wilson D, FREELEY M, HUANG D, Junquiang H, Gondarenko S, Hone J, Gadegaard N and Palma M (2022). "Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM." The Royal Society  Philosophical Transactions of The Royal Society B: Biological Sciences 
    21-11-2022
  • Iskratsch T, Wilson D and Tinker A (2022). "The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction." Nature Research  Communications Biology 
    27-09-2022
  • Swiatlowska P, Sit BHM, Zhen F, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones G, Yu C-H and Iskratsch T (2022). "Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching." American Association For The Advancement of Science  Science Advances 
    15-04-2022
  • Iskratsch T (2020). "Cell scientist to watch." Journal of Cell Science  vol. 133, (15)
    03-08-2020
  • Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T and Palma M (2019). "Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control." Royal Society of Chemistry (Rsc)  Faraday Discussions 
    18-03-2019

All Publications

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    2022

    • Iskratsch T, Hawkes W, Marhuenda E, Reynolds P, O'Neill C, PANDEY P, Wilson D, FREELEY M, HUANG D, Junquiang H, Gondarenko S, Hone J, Gadegaard N and Palma M (2022). "Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM." The Royal Society  Philosophical Transactions of The Royal Society B: Biological Sciences
      21-11-2022
    • Olson W, He R, Benedetto A, Iskratsch T, Shaitan K and Hall D (2022). "Editors’ roundup: October 2022." Biophysical Reviews vol. 14 (5), 1085-1091.
      01-10-2022
    • Iskratsch T, Wilson D and Tinker A (2022). "The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction." Nature Research  Communications Biology
      27-09-2022
    • Swiatlowska P, Sit BHM, Zhen F, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones G, Yu C-H and Iskratsch T (2022). "Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching." American Association For The Advancement of Science  Science Advances
      15-04-2022
    • Wilson DGS and Iskratsch T (2022). "Factoring in the force: A novel role for eIF6." The Journal of Cell Biology vol. 221 (2)
      01-02-2022

    2021

    • Swiatlowska P and Iskratsch T (2021). "Tools for studying and modulating (cardiac muscle) cell mechanics and mechanosensing across the scales." Biophysical Reviews vol. 13 (5), 611-623.
      01-10-2021
    • Swiatlowska P and Iskratsch T (2021). "Cardiovascular mechanobiology—a Special Issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology and disease." Springer (Part of Springer Nature)  Biophysical Reviews vol. 13 (5), 575-577.
      11-09-2021
    • Swiatlowska P and Iskratsch T (2021). "Announcing the call for the Special Issue on “Cardiovascular mechanobiology—a special issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology, and disease”." Biophysical Reviews vol. 13 (3), 307-308.
      01-06-2021
    • Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot JP, Duffau H, Dennis JW, Cornu D and Bakalara N (2021). "Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing." Journal of Experimental and Clinical Cancer Research vol. 40 (1)
      24-04-2021

    2020

    2019

    • Di Cio S, Iskratsch T, Connelly JT and Gautrot JE (2019). "Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing." Elsevier  Biomaterials vol. 232
      16-12-2019
    • Xanthis I and Iskratsch T (2019). "Lamin-A Mechano-Protects the Heart." Developmental Cell
      17-06-2019
    • Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T and Hodivala-Dilke K (2019). "Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation." American Association For Cancer Research  Cancer Research
      12-06-2019
    • Sit B, Gutmann D and Iskratsch T (2019). "Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing." Journal of Muscle Research and Cell Motility vol. 40 (2), 197-209.
      01-06-2019
    • Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T and Palma M (2019). "Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control." Royal Society of Chemistry (Rsc)  Faraday Discussions
      18-03-2019

    2018

    • Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, ISKRATSCH T and Lappalainen P (2018). "Calponin-3 is critical for coordinated contractility of actin stress fibers." Nature Publishing Group  Scientific Reports
      05-12-2018
    • Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). "Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions." Dev Cell vol. 44 (3), 326-336.e3.
      05-02-2018

    2017

    2016

    • Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML and Sheetz MP (2016). "Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability." Immunol Cell Biol vol. 94 (10), 981-993.
      30-06-2016
    • Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N, Tabdanov E, Lohner J, Gondarenko A, Chander AC, Roca-Cusachs P, O'Shaughnessy B, Hone J and Sheetz MP (2016). "α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions." Mol Biol Cell vol. 27 (22), 3471-3479.
      27-04-2016

    2015

    • Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B, Hone J and Sheetz MP (2015). "Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices." Nat Cell Biol vol. 18 (1), 33-42.
      30-11-2015
    • Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC and Iskratsch T (2015). "Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells." Integr Biol (Camb) vol. 7 (10), 1272-1284.
      03-07-2015

    2014

    • Wolfenson H, Iskratsch T and Sheetz MP (2014). "Early events in cell spreading as a model for quantitative analysis of biomechanical events." Biophysical Journal vol. 107 (11), 2508-2514.
      02-12-2014
    • Iskratsch T, Wolfenson H and Sheetz MP (2014). "Appreciating force and shape—the rise of mechanotransduction in cell biology." Nature Reviews. Molecular Cell Biology vol. 15 (12), 825-833.
      01-12-2014
    • Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG and Ehler E (2014). "The formin FHOD1 in cardiomyocytes." Anat Rec (Hoboken) vol. 297 (9), 1560-1570.
      14-08-2014
    • Zhang X, Moore SW, Iskratsch T and Sheetz MP (2014). "N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading." Journal of Cell Science vol. 127 (7), 1394-1405.
      01-01-2014

    2013

    • Iskratsch T, Yu CH, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E and Sheetz M (2013). "FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration." Developmental Cell vol. 27 (5), 545-559.
      09-12-2013
    • Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I and Ehler E (2013). "Two distinct phosphorylation events govern the function of muscle FHOD3." Cellular and Molecular Life Sciences vol. 70 (5), 893-908.
      01-03-2013
    • Lynch CD, Lazar AM, Iskratsch T, Zhang X and Sheetz MP (2013). "Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions." Molecular Biology of The Cell vol. 24 (1), 21-30.
      01-01-2013

    2012

    • Roca-Cusachs P, Iskratsch T and Sheetz MP (2012). "Finding the weakest link-exploring integrin-mediated mechanical molecular pathways." Journal of Cell Science vol. 125 (13), 3025-3038.
      01-07-2012
    • Dwyer J, Iskratsch T and Ehler E (2012). "Actin in striated muscle: Recent insights into assembly and maintenance." Biophysical Reviews vol. 4 (1), 17-25.
      01-03-2012

    2011

    2010

    • Iskratsch T, Lange S, Dwyer J, Kho AL, Remedios CD and Ehler E (2010). "Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance." The Journal of General Physiology vol. 137 (1), i1-i1.
      27-12-2010
    • Iskratsch T, Lange S, Dwyer J, Kho AL, Dos Remedios C and Ehler E (2010). "Formin follows function: A muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance." Journal of Cell Biology vol. 191 (6), 1159-1172.
      13-12-2010

    2009

    • Herbst R, Iskratsch T, Unger E and Bittner RE (2009). "Aberrant development of neuromuscular junctions in glycosylation-defective Largemyd mice." Neuromuscular Disorders vol. 19 (5), 366-378.
      01-05-2009
    • Gutternigg M, Rendić D, Voglauer R, Iskratsch T and Wilson IBH (2009). "Mammalian cells contain a second nucleocytoplasmic Hexosaminidase." Biochemical Journal vol. 419 (1), 83-90.
      01-04-2009
    • Iskratsch T, Braun A, Paschinger K and Wilson IBH (2009). "Specificity analysis of lectins and antibodies using remodeled glycoproteins." Analytical Biochemistry vol. 386 (2), 133-146.
      15-03-2009