Prof Thomas Iskratsch
Dipl.-Ing., PhD, FHEA
All Publications
Page 1 of 2
2026
- O21 Development of a functional 3D eccrine sweat gland model
Brook HB, Iskratsch T, Evans R, Connelly J
British Journal of Dermatology, Oxford University Press (Oup) vol. 194 (1)
06-01-2026
2025
- Mitochondrial Adaptation to Mechanical Stress in Cardiac Ageing and Disease
Prakash A, Iskratsch T
Advanced Science, Wiley vol. 13 (4)
28-11-2025 - Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI
Kapustin AN, Tsakali SS, Whitehead M, Chennell G, Wu M-Y, Molenaar C, Kutikhin A, Chen Y et al.
Elife, Elife vol. 12
30-09-2025 - Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling
Marhuenda E, Xanthis I, Smith PO, Prakash A, Kallem T, Pandey P, Wilson DGS, Azad A et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 11 (36)
05-09-2025 - Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes
Hargreaves E, Collinson R, Jenks AD, Staszewski A, Tsalikis A, Bodoque R, Arias-Garcia M, Abdi Y et al.
Life Science Alliance, Life Science Alliance vol. 8 (10)
18-08-2025 - Role of the extracellular matrix in cardiac ageing
Prakash A, Smith PO, Iskratsch T
Nature Materials, Springer Nature vol. 24 (9), 1337-1339.
18-08-2025
2024
- Biocooperative Regenerative Materials by Harnessing Blood‐Clotting and Peptide Self‐Assembly
Padilla‐Lopategui S, Ligorio C, Bu W, Yin C, Laurenza D, Redondo C, Owen R, Sun H et al.
Advanced Materials, Wiley vol. 36 (52)
14-11-2024 - Covariance estimation: Optimal dimension-free guarantees for adversarial corruption and heavy tails
Abdalla P, Zhivotovskiy N
Journal of The European Mathematical Society, European Mathematical Society - Ems - Publishing House vol. 28 (4), 1809-1847.
08-08-2024 - Mechano-epigenetic regulation of vascular smooth muscle cell phenotype in atherosclerosis
Swiatlowska P, Iskratsch T, Shanahan C
Atherosclerosis, Elsevier vol. 395
01-08-2024 - Tunable electrospun scaffolds of polyacrylonitrile loaded with carbon nanotubes: from synthesis to biological applications
Fromager B, Cambedouzou J, Marhuenda E, Iskratsch T, Pinault M, Bakalara N, Cornu D
Chembiochem, Wiley vol. 25 (7)
12-03-2024 - Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells (Adv. Sci. 9/2024)
Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D et al.
Advanced Science, Wiley vol. 11 (9)
01-03-2024 - Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness
Faleeva M, Ahmad S, Theofilatos K, Lynham S, Watson G, Whitehead M, Marhuenda E, Iskratsch T et al.
Circulation Research, Wolters Kluwer vol. 134 (3), 307-324.
05-01-2024 - Selective placement of functionalised DNA origami via thermal scanning probe lithography patterning
Zheng T, O’Neill C, Marshall JF, Iskratsch T, Palma M
Materials Advances, Royal Society of Chemistry (Rsc) vol. 5 (23), 9376-9382.
01-01-2024
2023
- Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells
Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D et al.
Advanced Science, Wiley vol. 11 (9)
25-12-2023 - Lem2 is essential for cardiac development by maintaining nuclear integrity
Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 119 (11), 2074-2088.
17-04-2023 - Myonuclear alterations associated with exercise are independent of age in humans
Battey E, Ross JA, Hoang A, Wilson DGS, Han Y, Levy Y, Pollock RD, Kalakoutis M et al.
The Journal of Physiology, Wiley vol. 603 (13), 3755-3775.
30-01-2023 - Cardiovascular Mechano-Epigenetics: Force-Dependent Regulation of Histone Modifications and Gene Regulation
Swiatlowska P, Iskratsch T
Cardiovascular Drugs and Therapy, Springer Nature vol. 38 (2), 215-222.
18-01-2023
2022
- Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids
Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T, Krause S
Biosensors and Bioelectronics, Elsevier vol. 223
21-12-2022 - Regulation of cardiomyocyte adhesion and mechanosignalling through distinct nanoscale behaviour of integrin ligands mimicking healthy or fibrotic extracellular matrix
Hawkes W, Marhuenda E, Reynolds P, O'Neill C, Pandey P, Wilson DGS, Freeley M, Huang D et al.
Philosophical Transactions of The Royal Society B Biological Sciences, The Royal Society vol. 377 (1864)
03-10-2022 - The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction
Wilson DGS, Tinker A, Iskratsch T
Communications Biology, Springer Nature vol. 5 (1)
27-09-2022 - Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching
Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 8 (15)
15-04-2022 - Factoring in the force: A novel role for eIF6.
Wilson DGS, Iskratsch T
The Journal of Cell Biology vol. 221 (2)
21-01-2022
2021
- Cardiovascular mechanobiology—a Special Issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology and disease
Swiatlowska P, Iskratsch T
Biophysical Reviews, Springer Nature vol. 13 (5), 575-577.
11-09-2021 - Tools for studying and modulating (cardiac muscle) cell mechanics and mechanosensing across the scales
Swiatlowska P, Iskratsch T
Biophysical Reviews, Springer Nature vol. 13 (5), 611-623.
05-09-2021 - Announcing the call for the Special Issue on “Cardiovascular mechanobiology—a special issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology, and disease”
Swiatlowska P, Iskratsch T
Biophysical Reviews, Springer Nature vol. 13 (3), 307-308.
03-05-2021 - Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing
Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J et al.
Journal of Experimental and Clinical Cancer Research vol. 40 (1)
24-04-2021
2020
- Cell scientist to watch – Thomas Iskratsch
Journal of Cell Science, The Company of Biologists vol. 133 (15)
01-08-2020
2019
- Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing
Di Cio S, Iskratsch T, Connelly JT, Gautrot JE
Biomaterials, Elsevier vol. 232
16-12-2019 - Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861
Pedrosa A-R, Bodrug N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 79 (17), 4371-4386.
01-09-2019 - Lamin-A Mechano-Protects the Heart
Xanthis I, Iskratsch T
Developmental Cell
17-06-2019 - Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing
Sit B, Gutmann D, Iskratsch T
Journal of Muscle Research and Cell Motility, Springer Nature vol. 40 (2), 197-209.
01-06-2019 - Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart
Ward M, Iskratsch T
Biochimica Et Biophysica Acta (Bba) - Molecular Cell Research, Elsevier vol. 1867 (3)
08-02-2019 - Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control
Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratsch T et al.
Faraday Discussions, Royal Society of Chemistry (Rsc) vol. 219, 203-219.
01-01-2019
2018
- Calponin-3 is critical for coordinated contractility of actin stress fibers
Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, Iskratsch T, Lappalainen P
Scientific Reports, Springer Nature vol. 8 (1)
05-12-2018 - Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions.
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L et al.
Dev Cell vol. 44 (3), 326-336.e3.
05-02-2018
2017
- Polymer fiber-based models of connective tissue repair and healing
Lee NM, Erisken C, Iskratsch T, Sheetz M, Levine WN, Lu HH
Biomaterials vol. 112, 303-312.
01-01-2017
2016
- Actin polymerization‐dependent activation of Cas‐L promotes immunological synapse stability
Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML et al.
Immunology and Cell Biology, Wiley vol. 94 (10), 981-993.
01-11-2016 - α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions
Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N et al.
Molecular Biology of The Cell, American Society For Cell Biology (Ascb) vol. 27 (22), 3471-3479.
27-04-2016
2015
- Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices
Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O’Shaughnessy B et al.
Nature Cell Biology, Springer Nature vol. 18 (1), 33-42.
30-11-2015 - Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells
Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC, Iskratsch T
Integrative Biology, Oxford University Press (Oup) vol. 7 (10), 1272-1284.
01-01-2015
2014
- Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events
Wolfenson H, Iskratsch T, Sheetz MP
Biophysical Journal, Elsevier vol. 107 (11), 2508-2514.
01-12-2014 - Appreciating force and shape—the rise of mechanotransduction in cell biology.
Iskratsch T, Wolfenson H, Sheetz MP
Nature Reviews. Molecular Cell Biology vol. 15 (12), 825-833.
30-10-2014 - The Formin FHOD1 in Cardiomyocytes
Dwyer J, Pluess M, Iskratsch T, dos Remedios CG, Ehler E
The Anatomical Record, Wiley vol. 297 (9), 1560-1570.
14-08-2014 - N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading
Zhang X, Moore SW, Iskratsch T, Sheetz MP
Journal of Cell Science, The Company of Biologists vol. 127 (7), 1394-1405.
01-01-2014
2013
- FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration
Iskratsch T, Yu C-H, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E et al.
Developmental Cell, Elsevier vol. 27 (5), 545-559.
01-12-2013
2012
- Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions
Lynch CD, Lazar AM, Iskratsch T, Zhang X, Sheetz MP
Molecular Biology of The Cell, American Society For Cell Biology (Ascb) vol. 24 (1), 21-30.
31-10-2012 - Two distinct phosphorylation events govern the function of muscle FHOD3
Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I, Ehler E
Cellular and Molecular Life Sciences, Springer Nature vol. 70 (5), 893-908.
04-10-2012 - Finding the weakest link – exploring integrin-mediated mechanical molecular pathways
Roca-Cusachs P, Iskratsch T, Sheetz MP
Journal of Cell Science, The Company of Biologists vol. 125 (13), 3025-3038.
01-01-2012
2011
- Actin in striated muscle: recent insights into assembly and maintenance
Dwyer J, Iskratsch T, Ehler E
Biophysical Reviews, Springer Nature vol. 4 (1), 17-25.
20-12-2011 - Formin-g muscle cytoarchitecture.
Iskratsch T, Ehler E
Bioarchitecture, Taylor & Francis vol. 1 (2), 66-68.
01-03-2011