Prof Thomas Iskratsch
Dipl.-Ing., PhD, FHEA
Key Publications
- Biocooperative Regenerative Materials by Harnessing Blood‐Clotting and Peptide Self‐Assembly
Padilla‐Lopategui S, Ligorio C, Bu W, Yin C, Laurenza D, Redondo C, Owen R, Sun H, Rose FRAJ, Iskratsch T and Mata A
Advanced Materials, Wiley vol. 36 (52)
14-11-2024 - Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness
Faleeva M, Ahmad S, Theofilatos K, Lynham S, Watson G, Whitehead M, Marhuenda E, Iskratsch T, Cox S and Shanahan CM
Circulation Research, Wolters Kluwer vol. 134 (3), 307-324.
05-01-2024 - Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells
Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D, Shanahan C and Iskratsch T
Advanced Science, Wiley vol. 11 (9)
25-12-2023 - Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching.
Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones GE, Yu C-H and Iskratsch T
Science Advances vol. 8 (15)
01-04-2022 - Cell scientist to watch – Thomas Iskratsch
Journal of Cell Science, The Company of Biologists vol. 133 (15)
01-08-2020
All Publications
2024
- Biocooperative Regenerative Materials by Harnessing Blood‐Clotting and Peptide Self‐Assembly
Padilla‐Lopategui S, Ligorio C, Bu W, Yin C, Laurenza D, Redondo C, Owen R, Sun H, Rose FRAJ, Iskratsch T and Mata A
Advanced Materials, Wiley vol. 36 (52)
14-11-2024 - Mechano-epigenetic regulation of vascular smooth muscle cell phenotype in atherosclerosis
Swiatlowska P, Iskratsch T and Shanahan C
Atherosclerosis, Elsevier vol. 395
01-08-2024 - Tunable electrospun scaffolds of polyacrylonitrile loaded with carbon nanotubes: from synthesis to biological applications
Fromager B, Cambedouzou J, Marhuenda E, Iskratsch T, Pinault M, Bakalara N and Cornu D
Chembiochem, Wiley vol. 25 (7)
12-03-2024 - Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells (Adv. Sci. 9/2024)
Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D, Shanahan C and Iskratsch T
Advanced Science, Wiley vol. 11 (9)
01-03-2024 - Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness
Faleeva M, Ahmad S, Theofilatos K, Lynham S, Watson G, Whitehead M, Marhuenda E, Iskratsch T, Cox S and Shanahan CM
Circulation Research, Wolters Kluwer vol. 134 (3), 307-324.
05-01-2024 - Selective placement of functionalised DNA origami via thermal scanning probe lithography patterning
Zheng T, O’Neill C, Marshall JF, Iskratsch T and Palma M
Materials Advances, Royal Society of Chemistry (Rsc) vol. 5 (23), 9376-9382.
01-01-2024
2023
- Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells
Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D, Shanahan C and Iskratsch T
Advanced Science, Wiley vol. 11 (9)
25-12-2023 - Lem2 is essential for cardiac development by maintaining nuclear integrity
Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D, Prin F, Mohun T, Catibog N, Tapia O, Gerace L, Iskratsch T, Shah AM and Stroud MJ
Cardiovascular Research, Oxford University Press (Oup) vol. 119 (11), 2074-2088.
17-04-2023 - Cardiovascular Mechano-Epigenetics: Force-Dependent Regulation of Histone Modifications and Gene Regulation
Swiatlowska P and Iskratsch T
Cardiovascular Drugs and Therapy, Springer Nature vol. 38 (2), 215-222.
18-01-2023 - Myonuclear alterations associated with exercise are independent of age in humans
Battey E, Ross JA, Hoang A, Wilson DGS, Han Y, Levy Y, Pollock RD, Kalakoutis M, Pugh JN, Close GL, Ellison‐Hughes GM, Lazarus NR, Iskratsch T, Harridge SDR, Ochala J and Stroud MJ
The Journal of Physiology, Wiley
04-01-2023
2022
- Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids
Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T and Krause S
Biosensors and Bioelectronics, Elsevier
21-12-2022 - Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM
Iskratsch T, Hawkes W, Marhuenda E, Reynolds P, O'Neill C, PANDEY P, Wilson D, FREELEY M, HUANG D, Junquiang H, Gondarenko S, Hone J, Gadegaard N and Palma M
Philosophical Transactions of The Royal Society B: Biological Sciences, The Royal Society
21-11-2022 - The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction
Iskratsch T, Wilson D and Tinker A
Communications Biology, Nature Research
27-09-2022 - Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching.
Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones GE, Yu C-H and Iskratsch T
Science Advances vol. 8 (15)
01-04-2022 - Factoring in the force: A novel role for eIF6.
Wilson DGS and Iskratsch T
The Journal of Cell Biology vol. 221 (2)
21-01-2022
2021
- Cardiovascular mechanobiology—a Special Issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology and disease
Swiatlowska P and Iskratsch T
Biophysical Reviews, Springer (Part of Springer Nature) vol. 13 (5), 575-577.
11-09-2021 - Tools for studying and modulating (cardiac muscle) cell mechanics and mechanosensing across the scales
Swiatlowska P and Iskratsch T
Biophysical Reviews, Springer Nature vol. 13 (5), 611-623.
05-09-2021 - Announcing the call for the Special Issue on “Cardiovascular mechanobiology—a special issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology, and disease”
Swiatlowska P and Iskratsch T
Biophysical Reviews, Springer Nature vol. 13 (3), 307-308.
03-05-2021 - Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing
Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot JP, Duffau H, Dennis JW, Cornu D and Bakalara N
Journal of Experimental and Clinical Cancer Research vol. 40 (1)
24-04-2021
2020
- Cell scientist to watch – Thomas Iskratsch
Journal of Cell Science, The Company of Biologists vol. 133 (15)
01-08-2020
2019
- Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing
Di Cio S, Iskratsch T, Connelly JT and Gautrot JE
Biomaterials, Elsevier vol. 232
16-12-2019 - Lamin-A Mechano-Protects the Heart
Xanthis I and Iskratsch T
Developmental Cell
17-06-2019 - Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation
Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T and Hodivala-Dilke K
Cancer Research, American Association For Cancer Research
12-06-2019 - Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing
Sit B, Gutmann D and Iskratsch T
Journal of Muscle Research and Cell Motility, Springer Nature vol. 40 (2), 197-209.
01-06-2019 - Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control
Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T and Palma M
Faraday Discussions, Royal Society of Chemistry (Rsc)
18-03-2019 - Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart
Ward M and Iskratsch T
Biochimica Et Biophysica Acta (Bba) - Molecular Cell Research, Elsevier vol. 1867 (3)
08-02-2019
2018
- Calponin-3 is critical for coordinated contractility of actin stress fibers
Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, ISKRATSCH T and Lappalainen P
Scientific Reports, Nature Publishing Group
05-12-2018 - Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions.
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T
Dev Cell vol. 44 (3), 326-336.e3.
05-02-2018
2017
- Polymer fiber-based models of connective tissue repair and healing
Lee NM, Erisken C, Iskratsch T, Sheetz M, Levine WN and Lu HH
Biomaterials vol. 112, 303-312.
01-01-2017
2016
- Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability.
Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML and Sheetz MP
Immunol Cell Biol vol. 94 (10), 981-993.
30-06-2016 - α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions.
Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N, Tabdanov E, Lohner J, Gondarenko A, Chander AC, Roca-Cusachs P, O'Shaughnessy B, Hone J and Sheetz MP
Mol Biol Cell vol. 27 (22), 3471-3479.
27-04-2016
2015
- Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices.
Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B, Hone J and Sheetz MP
Nat Cell Biol vol. 18 (1), 33-42.
30-11-2015 - Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells.
Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC and Iskratsch T
Integr Biol (Camb) vol. 7 (10), 1272-1284.
03-07-2015
2014
- Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events
Wolfenson H, Iskratsch T and Sheetz MP
Biophysical Journal, Elsevier vol. 107 (11), 2508-2514.
01-12-2014 - Appreciating force and shape—the rise of mechanotransduction in cell biology.
Iskratsch T, Wolfenson H and Sheetz MP
Nature Reviews. Molecular Cell Biology vol. 15 (12), 825-833.
30-10-2014 - The formin FHOD1 in cardiomyocytes.
Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG and Ehler E
Anat Rec (Hoboken) vol. 297 (9), 1560-1570.
14-08-2014 - N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading
Zhang X, Moore SW, Iskratsch T and Sheetz MP
Journal of Cell Science, The Company of Biologists vol. 127 (7), 1394-1405.
01-01-2014
2013
- FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration
Iskratsch T, Yu C-H, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E and Sheetz M
Developmental Cell, Elsevier vol. 27 (5), 545-559.
01-12-2013
2012
- Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions
Lynch CD, Lazar AM, Iskratsch T, Zhang X and Sheetz MP
Molecular Biology of The Cell, American Society For Cell Biology (Ascb) vol. 24 (1), 21-30.
31-10-2012 - Two distinct phosphorylation events govern the function of muscle FHOD3
Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I and Ehler E
Cellular and Molecular Life Sciences, Springer Nature vol. 70 (5), 893-908.
04-10-2012 - Finding the weakest link – exploring integrin-mediated mechanical molecular pathways
Roca-Cusachs P, Iskratsch T and Sheetz MP
Journal of Cell Science, The Company of Biologists vol. 125 (13), 3025-3038.
01-01-2012
2011
- Actin in striated muscle: recent insights into assembly and maintenance
Dwyer J, Iskratsch T and Ehler E
Biophysical Reviews, Springer Nature vol. 4 (1), 17-25.
20-12-2011 - Formin-g muscle cytoarchitecture.
Iskratsch T and Ehler E
Bioarchitecture, Taylor & Francis vol. 1 (2), 66-68.
01-03-2011
2010
- Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
Iskratsch T, Lange S, Dwyer J, Kho AL, Remedios CD and Ehler E
The Journal of General Physiology, Rockefeller University Press vol. 137 (1), i1-i1.
27-12-2010 - Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
Iskratsch T, Lange S, Dwyer J, Kho AL, dos Remedios C and Ehler E
Journal of Cell Biology, Rockefeller University Press vol. 191 (6), 1159-1172.
13-12-2010
2009
- Aberrant development of neuromuscular junctions in glycosylation-defective Largemyd mice
Herbst R, Iskratsch T, Unger E and Bittner RE
Neuromuscular Disorders, Elsevier vol. 19 (5), 366-378.
05-04-2009 - Mammalian cells contain a second nucleocytoplasmic hexosaminidase
Gutternigg M, Rendić D, Voglauer R, Iskratsch T and Wilson IBH
Biochemical Journal, Portland Press vol. 419 (1), 83-90.
13-03-2009
2008
- Specificity analysis of lectins and antibodies using remodeled glycoproteins
Iskratsch T, Braun A, Paschinger K and Wilson IBH
Analytical Biochemistry, Elsevier vol. 386 (2), 133-146.
14-12-2008