Prof Thomas Iskratsch
Dipl.-Ing., PhD, FHEA
All Publications
Page 1 of 2
2025
- Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI
Kapustin AN, Tsakali SS, Whitehead M, Chennell G, Wu M-Y, Molenaar C, Kutikhin A, Chen Y et al.
Elife, Elife vol. 12
30-09-2025 - Mechanosensitive biochemical imprinting of the talin interaction with DLC1 regulates RhoA activity and cardiomyocyte remodeling
Marhuenda E, Xanthis I, Smith PO, Prakash A, Kallem T, Pandey P, Wilson DGS, Azad A et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 11 (36)
05-09-2025 - Dysregulated SASS6 expression promotes increased ciliogenesis and cellinvasion phenotypes
Hargreaves E, Collinson R, Jenks A, Staszewski A, Tsalikis A, Bodoque R, Arias-Garcia M, Abdi Y et al.
Life Science Alliance, Cold Spring Harbor Laboratory Press
18-08-2025 - Role of the extracellular matrix in cardiac ageing
Iskratsch T, Prakash A, Smith P
Nature Materials, Nature Research
18-08-2025
2024
- Biocooperative Regenerative Materials by Harnessing Blood‐Clotting and Peptide Self‐Assembly
Padilla‐Lopategui S, Ligorio C, Bu W, Yin C, Laurenza D, Redondo C, Owen R, Sun H et al.
Advanced Materials, Wiley vol. 36 (52)
14-11-2024 - Mechano-epigenetic regulation of vascular smooth muscle cell phenotype in atherosclerosis
Swiatlowska P, Iskratsch T, Shanahan C
Atherosclerosis, Elsevier vol. 395
01-08-2024 - Tunable electrospun scaffolds of polyacrylonitrile loaded with carbon nanotubes: from synthesis to biological applications
Fromager B, Cambedouzou J, Marhuenda E, Iskratsch T, Pinault M, Bakalara N, Cornu D
Chembiochem, Wiley vol. 25 (7)
12-03-2024 - Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells (Adv. Sci. 9/2024)
Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D et al.
Advanced Science, Wiley vol. 11 (9)
01-03-2024 - Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness
Faleeva M, Ahmad S, Theofilatos K, Lynham S, Watson G, Whitehead M, Marhuenda E, Iskratsch T et al.
Circulation Research, Wolters Kluwer vol. 134 (3), 307-324.
05-01-2024 - Selective placement of functionalised DNA origami via thermal scanning probe lithography patterning
Zheng T, O’Neill C, Marshall JF, Iskratsch T, Palma M
Materials Advances, Royal Society of Chemistry (Rsc) vol. 5 (23), 9376-9382.
01-01-2024
2023
- Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells
Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D et al.
Advanced Science, Wiley vol. 11 (9)
25-12-2023 - Lem2 is essential for cardiac development by maintaining nuclear integrity
Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 119 (11), 2074-2088.
17-04-2023 - Myonuclear alterations associated with exercise are independent of age in humans
Battey E, Ross JA, Hoang A, Wilson DGS, Han Y, Levy Y, Pollock RD, Kalakoutis M et al.
The Journal of Physiology, Wiley vol. 603 (13), 3755-3775.
30-01-2023 - Cardiovascular Mechano-Epigenetics: Force-Dependent Regulation of Histone Modifications and Gene Regulation
Swiatlowska P, Iskratsch T
Cardiovascular Drugs and Therapy, Springer
18-01-2023
2022
- Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids
Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T, Krause S
Biosensors and Bioelectronics, Elsevier
21-12-2022 - Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM
Iskratsch T, Hawkes W, Marhuenda E, Reynolds P, O'Neill C, PANDEY P, Wilson D, FREELEY M et al.
Philosophical Transactions of The Royal Society B: Biological Sciences, The Royal Society
21-11-2022 - The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction
Iskratsch T, Wilson D, Tinker A
Communications Biology, Nature Research
27-09-2022 - Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching
Swiatlowska P, Sit BHM, Zhen F, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X et al.
Science Advances, American Association For The Advancement of Science
15-04-2022 - Factoring in the force: A novel role for eIF6.
Wilson DGS, Iskratsch T
The Journal of Cell Biology vol. 221 (2)
21-01-2022
2021
- Cardiovascular mechanobiology—a Special Issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology and disease
Swiatlowska P, Iskratsch T
Biophysical Reviews, Springer (Part of Springer Nature) vol. 13 (5), 575-577.
11-09-2021 - Tools for studying and modulating (cardiac muscle) cell mechanics and mechanosensing across the scales
Swiatlowska P, Iskratsch T
Biophysical Reviews, Springer Nature vol. 13 (5), 611-623.
05-09-2021 - Announcing the call for the Special Issue on “Cardiovascular mechanobiology—a special issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology, and disease”
Swiatlowska P, Iskratsch T
Biophysical Reviews, Springer Nature vol. 13 (3), 307-308.
03-05-2021 - Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing
Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J et al.
Journal of Experimental and Clinical Cancer Research vol. 40 (1)
24-04-2021
2020
- Cell scientist to watch – Thomas Iskratsch
Journal of Cell Science, The Company of Biologists vol. 133 (15)
01-08-2020
2019
- Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing
Di Cio S, Iskratsch T, Connelly JT, Gautrot JE
Biomaterials, Elsevier vol. 232
16-12-2019 - Lamin-A Mechano-Protects the Heart
Xanthis I, Iskratsch T
Developmental Cell
17-06-2019 - Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation
Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM et al.
Cancer Research, American Association For Cancer Research
12-06-2019 - Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing
Sit B, Gutmann D, Iskratsch T
Journal of Muscle Research and Cell Motility, Springer Nature vol. 40 (2), 197-209.
01-06-2019 - Probing the nanoscale organisation and multivalency of cell surface receptors:\nDNA origami nanoarrays for cellular studies with single-molecule control
Hawkes W, HUANG D, Reynolds P, HAMMOND L, WARD M, Gadegaard N, MARSHALL J, ISKRATSCH T et al.
Faraday Discussions, Royal Society of Chemistry
18-03-2019 - Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart
Ward M, Iskratsch T
Biochimica Et Biophysica Acta (Bba) - Molecular Cell Research, Elsevier vol. 1867 (3)
08-02-2019
2018
- Calponin-3 is critical for coordinated contractility of actin stress fibers
Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, ISKRATSCH T, Lappalainen P
Scientific Reports, Nature Publishing Group
05-12-2018 - Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions.
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L et al.
Dev Cell vol. 44 (3), 326-336.e3.
05-02-2018
2017
- Polymer fiber-based models of connective tissue repair and healing
Lee NM, Erisken C, Iskratsch T, Sheetz M, Levine WN, Lu HH
Biomaterials vol. 112, 303-312.
01-01-2017
2016
- Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability.
Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML et al.
Immunol Cell Biol vol. 94 (10), 981-993.
30-06-2016 - α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions.
Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N et al.
Mol Biol Cell vol. 27 (22), 3471-3479.
27-04-2016
2015
- Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices.
Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B et al.
Nat Cell Biol vol. 18 (1), 33-42.
30-11-2015 - Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells.
Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC, Iskratsch T
Integr Biol (Camb) vol. 7 (10), 1272-1284.
03-07-2015
2014
- Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events
Wolfenson H, Iskratsch T, Sheetz MP
Biophysical Journal, Elsevier vol. 107 (11), 2508-2514.
01-12-2014 - Appreciating force and shape—the rise of mechanotransduction in cell biology.
Iskratsch T, Wolfenson H, Sheetz MP
Nature Reviews. Molecular Cell Biology vol. 15 (12), 825-833.
30-10-2014 - The formin FHOD1 in cardiomyocytes.
Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG, Ehler E
Anat Rec (Hoboken) vol. 297 (9), 1560-1570.
14-08-2014 - N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading
Zhang X, Moore SW, Iskratsch T, Sheetz MP
Journal of Cell Science, The Company of Biologists vol. 127 (7), 1394-1405.
01-01-2014
2013
- FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration
Iskratsch T, Yu C-H, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E et al.
Developmental Cell, Elsevier vol. 27 (5), 545-559.
01-12-2013
2012
- Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions
Lynch CD, Lazar AM, Iskratsch T, Zhang X, Sheetz MP
Molecular Biology of The Cell, American Society For Cell Biology (Ascb) vol. 24 (1), 21-30.
31-10-2012 - Two distinct phosphorylation events govern the function of muscle FHOD3
Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I, Ehler E
Cellular and Molecular Life Sciences, Springer Nature vol. 70 (5), 893-908.
04-10-2012 - Finding the weakest link – exploring integrin-mediated mechanical molecular pathways
Roca-Cusachs P, Iskratsch T, Sheetz MP
Journal of Cell Science, The Company of Biologists vol. 125 (13), 3025-3038.
01-01-2012
2011
- Actin in striated muscle: recent insights into assembly and maintenance
Dwyer J, Iskratsch T, Ehler E
Biophysical Reviews, Springer Nature vol. 4 (1), 17-25.
20-12-2011 - Formin-g muscle cytoarchitecture.
Iskratsch T, Ehler E
Bioarchitecture, Taylor & Francis vol. 1 (2), 66-68.
01-03-2011
2010
- Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
Iskratsch T, Lange S, Dwyer J, Kho AL, Remedios CD, Ehler E
Journal of General Physiology, Rockefeller University Press vol. 137 (1), i1-i1.
27-12-2010 - Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
Iskratsch T, Lange S, Dwyer J, Kho AL, dos Remedios C, Ehler E
Journal of Cell Biology, Rockefeller University Press vol. 191 (6), 1159-1172.
13-12-2010
2009
- Aberrant development of neuromuscular junctions in glycosylation-defective Largemyd mice
Herbst R, Iskratsch T, Unger E, Bittner RE
Neuromuscular Disorders, Elsevier vol. 19 (5), 366-378.
05-04-2009