Prof Thomas Iskratsch
Dipl.-Ing., PhD, FHEA
All Publications
Page 1 of 2
2025
- Dysregulated SASS6 expression promotes increased ciliogenesis and cell invasion phenotypes
Hargreaves E, Collinson R, Jenks AD, Staszewski A, Tsalikis A, Bodoque R, Arias-Garcia M, Abdi Y et al.
Life Science Alliance, Life Science Alliance, Llc vol. 8 (10), e202402820-e202402820.
18-08-2025 - Role of the extracellular matrix in cardiac ageing
Prakash A, Smith PO, Iskratsch T
Nature Materials, Springer Science and Business Media Llc vol. 24 (9), 1337-1339.
18-08-2025
2024
- Biocooperative Regenerative Materials by Harnessing Blood-Clotting and Peptide Self-Assembly
Padilla-Lopategui S, Ligorio C, Bu W, Yin C, Laurenza D, Redondo C, Owen R, Sun H et al.
Advanced Materials vol. 36 (52)
27-12-2024 - Mechano-epigenetic regulation of vascular smooth muscle cell phenotype in atherosclerosis
Swiatlowska P, Iskratsch T, Shanahan C
Atherosclerosis, Elsevier Bv vol. 395, 118395-118395.
01-08-2024 - Tunable electrospun scaffolds of polyacrylonitrile loaded with carbon nanotubes: from synthesis to biological applications
Fromager B, Cambedouzou J, Marhuenda E, Iskratsch T, Pinault M, Bakalara N, Cornu D
Chembiochem, Wiley vol. 25 (7)
12-03-2024 - Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells (Adv. Sci. 9/2024)
Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D et al.
Advanced Science, Wiley vol. 11 (9)
01-03-2024 - Sox9 Accelerates Vascular Aging by Regulating Extracellular Matrix Composition and Stiffness
Faleeva M, Ahmad S, Theofilatos K, Lynham S, Watson G, Whitehead M, Marhuenda E, Iskratsch T et al.
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 134 (3), 307-324.
02-02-2024 - Selective placement of functionalised DNA origami via thermal scanning probe lithography patterning
Zheng T, O’Neill C, Marshall JF, Iskratsch T, Palma M
Materials Advances, Royal Society of Chemistry (Rsc) vol. 5 (23), 9376-9382.
01-01-2024
2023
- Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells
Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D et al.
Advanced Science, Wiley vol. 11 (9)
25-12-2023 - Lem2 is essential for cardiac development by maintaining nuclear integrity
Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D et al.
Cardiovascular Research, Oxford University Press (Oup) vol. 119 (11), 2074-2088.
17-04-2023 - Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids
Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T, Krause S
Biosensors and Bioelectronics, Elsevier Bv vol. 223, 115024-115024.
01-03-2023 - Myonuclear alterations associated with exercise are independent of age in humans
Battey E, Ross JA, Hoang A, Wilson DGS, Han Y, Levy Y, Pollock RD, Kalakoutis M et al.
The Journal of Physiology, Wiley vol. 603 (13), 3755-3775.
30-01-2023 - Cardiovascular Mechano-Epigenetics: Force-Dependent Regulation of Histone Modifications and Gene Regulation
Swiatlowska P, Iskratsch T
Cardiovascular Drugs and Therapy, Springer Science and Business Media Llc vol. 38 (2), 215-222.
18-01-2023
2022
- Regulation of cardiomyocyte adhesion and mechanosignalling through distinct nanoscale behaviour of integrin ligands mimicking healthy or fibrotic extracellular matrix
Hawkes W, Marhuenda E, Reynolds P, O'Neill C, Pandey P, Samuel Wilson DG, Freeley M, Huang D et al.
Philosophical Transactions of The Royal Society B: Biological Sciences, The Royal Society vol. 377 (1864)
03-10-2022 - The role of the dystrophin glycoprotein complex in muscle cell mechanotransduction
Wilson DGS, Tinker A, Iskratsch T
Communications Biology, Springer Science and Business Media Llc vol. 5 (1)
27-09-2022 - Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching
Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 8 (15)
15-04-2022 - Factoring in the force: A novel role for eIF6
Wilson DGS, Iskratsch T
Journal of Cell Biology, Rockefeller University Press vol. 221 (2)
21-01-2022
2021
- Cardiovascular mechanobiology—a Special Issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology and disease
Swiatlowska P, Iskratsch T
Biophysical Reviews, Springer Science and Business Media Llc vol. 13 (5), 575-577.
11-09-2021 - Tools for studying and modulating (cardiac muscle) cell mechanics and mechanosensing across the scales
Swiatlowska P, Iskratsch T
Biophysical Reviews, Springer Science and Business Media Llc vol. 13 (5), 611-623.
05-09-2021 - Announcing the call for the Special Issue on “Cardiovascular mechanobiology—a special issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology, and disease”
Swiatlowska P, Iskratsch T
Biophysical Reviews, Springer Science and Business Media Llc vol. 13 (3), 307-308.
03-05-2021 - Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing
Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J et al.
Journal of Experimental &Amp; Clinical Cancer Research, Springer Science and Business Media Llc vol. 40 (1)
24-04-2021
2020
- Cell scientist to watch – Thomas Iskratsch
Journal of Cell Science, The Company of Biologists vol. 133 (15)
01-08-2020 - Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart
Ward M, Iskratsch T
Biochimica Et Biophysica Acta (Bba) - Molecular Cell Research, Elsevier Bv vol. 1867 (3), 118436-118436.
01-03-2020 - Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing
Di Cio S, Iskratsch T, Connelly JT, Gautrot JE
Biomaterials, Elsevier Bv vol. 232, 119683-119683.
01-02-2020
2019
- Tumor Angiogenesis Is Differentially Regulated by Phosphorylation of Endothelial Cell Focal Adhesion Kinase Tyrosines-397 and -861
Pedrosa A-R, Bodrug N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 79 (17), 4371-4386.
01-09-2019 - Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing
Sit B, Gutmann D, Iskratsch T
Journal of Muscle Research and Cell Motility, Springer Science and Business Media Llc vol. 40 (2), 197-209.
01-06-2019 - Lamin-A Mechano-Protects the Heart
Xanthis I, Iskratsch T
Developmental Cell, Elsevier Bv vol. 49 (6), 821-822.
01-06-2019 - Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control
Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratsch T et al.
Faraday Discussions, Royal Society of Chemistry (Rsc) vol. 219, 203-219.
01-01-2019
2018
- Calponin-3 is critical for coordinated contractility of actin stress fibers
Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, Iskratsch T, Lappalainen P
Scientific Reports, Springer Science and Business Media Llc vol. 8 (1)
05-12-2018 - Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions
Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L et al.
Developmental Cell, Elsevier Bv vol. 44 (3), 326-336.e3.
01-02-2018
2017
- Polymer fiber-based models of connective tissue repair and healing
Lee NM, Erisken C, Iskratsch T, Sheetz M, Levine WN, Lu HH
Biomaterials, Elsevier Bv vol. 112, 303-312.
01-01-2017
2016
- α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions
Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N et al.
Molecular Biology of The Cell, American Society For Cell Biology (Ascb) vol. 27 (22), 3471-3479.
07-11-2016 - Actin polymerization‐dependent activation of Cas‐L promotes immunological synapse stability
Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML et al.
Immunology &Amp; Cell Biology, Wiley vol. 94 (10), 981-993.
01-11-2016
2015
- Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices
Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O’Shaughnessy B et al.
Nature Cell Biology, Springer Science and Business Media Llc vol. 18 (1), 33-42.
30-11-2015 - Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells
Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC, Iskratsch T
Integrative Biology, Oxford University Press (Oup) vol. 7 (10), 1272-1284.
01-01-2015
2014
- Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events
Wolfenson H, Iskratsch T, Sheetz MP
Biophysical Journal, Elsevier Bv vol. 107 (11), 2508-2514.
01-12-2014 - Appreciating force and shape — the rise of mechanotransduction in cell biology
Iskratsch T, Wolfenson H, Sheetz MP
Nature Reviews Molecular Cell Biology, Springer Science and Business Media Llc vol. 15 (12), 825-833.
30-10-2014 - The Formin FHOD1 in Cardiomyocytes
Dwyer J, Pluess M, Iskratsch T, dos Remedios CG, Ehler E
The Anatomical Record, Wiley vol. 297 (9), 1560-1570.
14-08-2014 - N-WASP-directed actin polymerization activates p130Cas phosphorylation and lamellipodium spreading
Zhang X, Moore SW, Iskratsch T, Sheetz MP
Journal of Cell Science, The Company of Biologists
01-01-2014
2013
- FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration
Iskratsch T, Yu C-H, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E et al.
Developmental Cell, Elsevier Bv vol. 27 (5), 545-559.
01-12-2013 - Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions
Lynch CD, Lazar AM, Iskratsch T, Zhang X, Sheetz MP
Molecular Biology of The Cell, American Society For Cell Biology (Ascb) vol. 24 (1), 21-30.
01-01-2013
2012
- Two distinct phosphorylation events govern the function of muscle FHOD3
Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I, Ehler E
Cellular and Molecular Life Sciences, Springer Science and Business Media Llc vol. 70 (5), 893-908.
04-10-2012 - Finding the weakest link – exploring integrin-mediated mechanical molecular pathways
Roca-Cusachs P, Iskratsch T, Sheetz MP
Journal of Cell Science, The Company of Biologists
01-01-2012
2011
- Actin in striated muscle: recent insights into assembly and maintenance
Dwyer J, Iskratsch T, Ehler E
Biophysical Reviews, Springer Science and Business Media Llc vol. 4 (1), 17-25.
20-12-2011 - Formin-g muscle cytoarchitecture
Iskratsch T, Ehler E
Bioarchitecture, Informa Uk Limited vol. 1 (2), 66-68.
01-03-2011
2010
- Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
Iskratsch T, Lange S, Dwyer J, Kho AL, Remedios CD, Ehler E
The Journal of General Physiology, Rockefeller University Press vol. 137 (1), i1-i1.
27-12-2010 - Formin follows function: a muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance
Iskratsch T, Lange S, Dwyer J, Kho AL, Remedios CD, Ehler E
Journal of Cell Biology, Rockefeller University Press vol. 191 (6), 1159-1172.
13-12-2010
2009
- Aberrant development of neuromuscular junctions in glycosylation-defective Largemyd mice
Herbst R, Iskratsch T, Unger E, Bittner RE
Neuromuscular Disorders, Elsevier Bv vol. 19 (5), 366-378.
01-05-2009 - Mammalian cells contain a second nucleocytoplasmic hexosaminidase
Gutternigg M, Rendić D, Voglauer R, Iskratsch T, Wilson IBH
Biochemical Journal, Portland Press Ltd. vol. 419 (1), 83-90.
13-03-2009 - Specificity analysis of lectins and antibodies using remodeled glycoproteins
Iskratsch T, Braun A, Paschinger K, Wilson IBH
Analytical Biochemistry, Elsevier Bv vol. 386 (2), 133-146.
01-03-2009