Prof Martin Knight
BEng, MSc, PhD, FHEA

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2010

• Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation
  Wann AKT, Mistry J, Blain EJ, Michael-Titus AT, Knight MM
  Arthritis Research and Therapy vol. 12 (6) 
  DOI 10.1186/ar3183

  QMRO
  
  08-11-2010
• Both superficial and deep zone articular chondrocyte subpopulations exhibit the crabtree effect but have different basal oxygen consumption rates
  Heywood HK, Knight MM, Lee DA
  Journal of Cellular Physiology vol. 223 (3), 630-639.  
  DOI 10.1002/jcp.22061
  
  01-06-2010
• Cyclic loading opens hemichannels to release ATP as part of a chondrocyte mechanotransduction pathway
  Garcia M, Knight MM
  Journal of Orthopaedic Research vol. 28 (4), 510-515.  
  DOI 10.1002/jor.21025
  
  01-04-2010
• 1P338 1J1450 Mechano-regulation of gap junction communications between tenocytes within isolated fascicles(Bioengineering,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)
  Maeda E, Ye S, Knight M, Wang W, Bader D, Lee D
  Seibutsu Butsuri, Biophysical Society of Japan vol. 50 (supplement2) 
  DOI 10.2142/biophys.50.s79_4
  
  01-01-2010
• A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles
  Ye S, Maeda E, Knight M, Lee D, Bader D, Wang W
  Faseb Journal vol. 24 
  DOI 10.1096/fasebj.24.1_supplement.975.9
  
  01-01-2010
• Measuring the biomechanical properties of cartilage cells
  Bader DL, Knight MM
  , 106-136.  
  DOI 10.1533/9781845697792.1.106
  
  01-01-2010
• Mechanical loading modulates chondrocyte primary cilia incidence and length
  McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S, Poole CA
  Cell Biology International vol. 34 (5), 441-446.  
  DOI 10.1042/CBI20090094
  
  01-01-2010

2009

• Articular chondrocytes express connexin 43 hemichannels and P2 receptors - A putative mechanoreceptor complex involving the primary cilium?
  Knight MM, Mcglashan SR, Garcia M, Jensen CG, Poole CA
  Journal of Anatomy vol. 214 (2), 275-283.  
  DOI 10.1111/j.1469-7580.2008.01021.x
  
  05-02-2009

2008

• Biomechanical analysis of structural deformation in living cells
  Bader DL, Knight MM
  Medical and Biological Engineering and Computing vol. 46 (10), 951-963.  
  DOI 10.1007/s11517-008-0381-4
  
  27-08-2008

2007

• Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes
  Campbell JJ, Blain EJ, Chowdhury TT, Knight MM
  Biochemical and Biophysical Research Communications vol. 361 (2), 329-334.  
  DOI 10.1016/j.bbrc.2007.06.185
  
  21-09-2007
• Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes
  KNIGHT MM, Chowdhury TT, Campbell JJ, Blain EJ
  Biochemical and Biophysical Research Communications vol. 361 (21), 329-334.  
  DOI 10.1016/j.bbrc.2007.06.185
  
  01-09-2007
• An improved confocal FRAP technique for the measurement of long-term actin dynamics in individual stress fibers
  Campbell JJ, Knight MM
  Microscopy Research and Technique vol. 70 (12), 1034-1040.  
  DOI 10.1002/jemt.20513
  
  01-01-2007

2006

• Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression
  Chowdhury TT, Knight MM
  Journal of Cellular Physiology vol. 209 (3), 845-853.  
  DOI 10.1002/jcp.20768
  
  01-12-2006
• Cyclic compression of chondrocytes modulates a purinergic calcium signalling pathway in a strain rate- and frequency-dependent manner
  Pingguan-Murphy B, El-Azzeh M, Bader DL, Knight MM
  Journal of Cellular Physiology vol. 209 (2), 389-397.  
  DOI 10.1002/jcp.20747
  
  01-11-2006
• Mitochondrial dynamics in chondrocytes and their connection to the mechanical properties of the cytoplasm
  Bomzon Z, Knight MM, Bader DL, Kimmel E
  Journal of Biomechanical Engineering vol. 128 (5), 674-679.  
  DOI 10.1115/1.2246239
  
  01-10-2006
• Ultrastructure of insect and spider cocoon silks
  Hakimi O, Knight DP, Knight MM, Grahn MF, Vadgama P
  Biomacromolecules vol. 7 (10), 2901-2908.  
  DOI 10.1021/bm060528h
  
  01-10-2006
• Intracellular mechanics and mechanotransduction associated with chondrocyte deformation during pipette aspiration
  Ohashi T, Hagiwara M, Bader DL, Knight MM
  Biorheology vol. 43 (3-4), 201-214.  
  DOI 10.1177/0006355x2006043003004005
  
  18-08-2006
• Chondrocyte deformation induces mitochondrial distortion and heterogeneous intracellular strain fields
  Knight MM, Bomzon Z, Kimmel E, Sharma AM, Lee DA, Bader DL
  Biomech Model Mechan vol. 5 (2-3), 180-191.  
  DOI 10.1007/s10237-006-0020-7
  
  01-06-2006
• Chondrocyte Deformation and Mechanotransduction in Cartilage Model Systems(International Workshop 2)
  Bader DL, Lee DA, Knight MM
  The Proceedings of The Bioengineering Conference Annual Meeting of Bed/Jsme, Japan Society of Mechanical Engineers vol. 2005.18, 2-3.  
  DOI 10.1299/jsmebio.2005.18.2
  
  01-01-2006
• Mechanical compression and hydrostatic pressure induce reversible changes in actin cytoskeletal organisation in chondrocytes in agarose.
  Knight MM, Toyoda T, Lee DA, Bader DL
  J Biomech vol. 39 (8), 1547-1551.  
  DOI 10.1016/j.jbiomech.2005.04.006
  
  01-01-2006
• Probing mechanical heterogeneity in chondrocytes using passive microtheology
  Bomzon Z, Knight MM, Bader DL, Kimmel E
  Journal of Biomechanics, Elsevier vol. 39 
  DOI 10.1016/s0021-9290(06)83854-6
  
  01-01-2006

2005

• Activation of chondrocytes calcium signalling by dynamic compression is independent of number of cycles.
  Pingguan-Murphy B, Lee DA, Bader DL, Knight MM
  Arch Biochem Biophys vol. 444 (1), 45-51.  
  DOI 10.1016/j.abb.2005.09.015
  
  01-12-2005

2004

• Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear.
  Sawae Y, Shelton JC, Bader DL, Knight MM
  Ann Biomed Eng vol. 32 (6), 860-870.  
  DOI 10.1023/b:abme.0000030261.38396.c0
  
  01-06-2004
• Increased presence of cells with multiple elongated processes in osteoarthritic femoral head cartilage.
  Holloway I, Kayser M, Lee DA, Bader DL, Bentley G, Knight MM
  Osteoarthritis Cartilage vol. 12 (1), 17-24.  
  DOI 10.1016/j.joca.2003.09.001
  
  01-01-2004
• Mechanical loading of chondrocytes embedded in 3D constructs: in vitro methods for assessment of morphological and metabolic response to compressive strain.
  Lee DA, Knight MM
  Methods Mol Med vol. 100, 307-324.  
  DOI 10.1385/1-59259-810-2:307
  
  01-01-2004

2003

• Live cell imaging using confocal microscopy induces intracellular calcium transients and cell death.
  Knight MM, Roberts SR, Lee DA, Bader DL
  Am J Physiol Cell Physiol vol. 284 (4), C1083-C1089.  
  DOI 10.1152/ajpcell.00276.2002
  
  01-04-2003
• Confocal Analysis of Local and Cellular Strains in Chondrocyte - Agarose Constructs Subjected to Shear.
  Bader DL, SHELTON JC, Knight MM, Sawae Y
  J Biochemical Engineering Asme 
  DOI 10.1023/B:ABME.0000030261.38396.c0
  
  01-01-2003

2002

• Cell and nucleus deformation in compressed chondrocyte-alginate constructs: temporal changes and calculation of cell modulus.
  Knight MM, van de Breevaart Bravenboer J, Lee DA, van Osch GJVM, Weinans H, Bader DL
  Biochim Biophys Acta vol. 1570 (1), 1-8.  
  DOI 10.1016/s0304-4165(02)00144-7
  
  15-02-2002

2001

• Chondrocyte deformation within mechanically and enzymatically extracted chondrons compressed in agarose.
  Knight MM, Ross JM, Sherwin AF, Lee DA, Bader DL, Poole CA
  Biochim Biophys Acta vol. 1526 (2), 141-146.  
  DOI 10.1016/s0304-4165(01)00118-0
  
  03-05-2001
• Temporal changes in cytoskeletal organisation within isolated chondrocytes quantified using a novel image analysis technique.
  Knight MM, Idowu BD, Lee DA, Bader DL
  Med Biol Eng Comput vol. 39 (3), 397-404.  
  DOI 10.1007/BF02345297
  
  01-05-2001
• Mechanical compression influences intracellular Ca2+ signaling in chondrocytes seeded in agarose constructs.
  Roberts SR, Knight MM, Lee DA, Bader DL
  J Appl Physiol (1985) vol. 90 (4), 1385-1391.  
  DOI 10.1152/jappl.2001.90.4.1385
  
  01-04-2001
• Compressive deformation and damage of muscle cell subpopulations in a model system.
  Bouten CV, Knight MM, Lee DA, Bade DL
  Ann Biomed Eng vol. 29 (2), 153-163.  
  DOI 10.1114/1.1349698
  
  01-02-2001

2000

• Confocal analysis of cytoskeletal organisation within isolated chondrocyte sub-populations cultured in agarose.
  Idowu BD, Knight MM, Bader DL, Lee DA
  Histochem J vol. 32 (3), 165-174.  
  DOI 10.1023/a:1004095207330
  
  01-03-2000
• Beta transition and stress-induced phase separation in the spinning of spider dragline silk
  Knight DP, KNIGHT MM, Vollrath F
  International Journal of Biological Macromolecules vol. 27 (3), 205-210.  
  DOI 10.1016/s0141-8130(00)00124-0
  
  01-01-2000
• Chondrocyte deformation within compressed agarose constructs at the cellular and sub-cellular levels.
  Lee DA, Knight MM, Bolton JF, Idowu BD, Kayser MV, Bader DL
  J Biomech vol. 33 (1), 81-95.  
  DOI 10.1016/s0021-9290(99)00160-8
  
  01-01-2000

1998

• Response of chondrocyte subpopulations cultured within unloaded and loaded agarose.
  Lee DA, Noguchi T, Knight MM, O'Donnell L, Bentley G, Bader DL
  J Orthop Res vol. 16 (6), 726-733.  
  DOI 10.1002/jor.1100160615
  
  01-11-1998
• The influence of elaborated pericellular matrix on the deformation of isolated articular chondrocytes cultured in agarose.
  Knight MM, Lee DA, Bader DL
  Biochim Biophys Acta vol. 1405 (1-3), 67-77.  
  DOI 10.1016/s0167-4889(98)00102-5
  
  21-10-1998
• Measurement of the deformation of isolated chondrocytes in agarose subjected to cyclic compression.
  Knight MM, Ghori SA, Lee DA, Bader DL
  Med Eng Phys vol. 20 (9), 684-688.  
  DOI 10.1016/s1350-4533(98)00080-0
  
  01-01-1998

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