Prof Martin Knight
BEng, MSc, PhD, FHEA
All Publications
Page 1 of 3
2025
- Pulsatile low shear stress increases susceptibility to endothelial inflammation via upregulation of IFT and activation of YAP
Hou Y, Screen HRC, Knight MM
Apl Bioengineering, Aip Publishing vol. 9 (2)
01-06-2025 - Engineering growth factor gradients to drive spatiotemporal tissue patterning in organ-on-a-chip systems
Hopkins T, Midha S, Grossemy S, Screen HRC, Wann AKT, Knight MM
Journal of Tissue Engineering, Sage Publications vol. 16
18-04-2025
2024
- Nonlinear Stress‐Induced Transformations in Collagen Fibrillar Organization, Disorder and Strain Mechanisms in the Bone‐Cartilage Unit
Badar W, Inamdar SR, Fratzl P, Snow T, Terrill NJ, Knight MM, Gupta HS
Advanced Science, Wiley vol. 12 (1)
11-11-2024 - Air Pollution and Osteoporosis
Allen O, Knight MM, Verbruggen SW
Current Osteoporosis Reports, Springer Science and Business Media Llc
20-09-2024 - A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer
Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT et al.
Advanced Healthcare Materials, Wiley vol. 13 (17)
22-03-2024
2023
- A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells
Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR, Knight MM
Advanced Science, Wiley vol. 11 (2), 2305842-2305842.
15-11-2023 - Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment
Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT, Knight MM
Biomedical Materials, IOP Publishing vol. 18 (6)
10-10-2023 - YAP activation inhibits inflammatory signalling and cartilage breakdown associated with reduced primary cilia expression
Meng H, Fu S, Ferreira MB, Hou Y, Pearce OM, Gavara N, Knight MM
Osteoarthritis and Cartilage, Elsevier Bv vol. 31 (5), 600-612.
01-05-2023 - Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
Nolan J, Pearce OMT, Screen HRC, Knight MM, Verbruggen SW
Cancers, Mdpi vol. 15 (3)
19-01-2023
2022
- Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion
Hayward M-K, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF, Jones JL
Npj Breast Cancer, Springer Science and Business Media Llc vol. 8 (1)
20-09-2022 - Collagen pre-strain discontinuity at the bone—Cartilage interface
Badar W, Ali H, Brooker ON, Newham E, Snow T, Terrill NJ, Tozzi G, Fratzl P et al.
Plos One, Public Library of Science (Plos) vol. 17 (9), e0273832-e0273832.
15-09-2022 - Oscillations of the circadian clock protein, BMAL-1, align to daily cycles of mechanical stimuli: a novel means to integrate biological time within predictive in vitro model systems
Heywood HK, Gardner L, Knight MM, Lee DA
In Vitro Models, Springer Science and Business Media Llc vol. 1 (6), 405-412.
31-08-2022
2021
- Reversible changes in the 3D collagen fibril architecture during cyclic loading of healthy and degraded cartilage
Inamdar SR, Prévost S, Terrill NJ, Knight MM, Gupta HS
Acta Biomaterialia, Elsevier Bv vol. 136, 314-326.
01-12-2021 - Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR, Knight MM
Cancers, Mdpi vol. 13 (12)
10-06-2021 - A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion
Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M et al.
Iscience, Elsevier Bv vol. 24 (6), 102676-102676.
01-06-2021 - Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT et al.
Iscience, Elsevier Bv vol. 24 (6), 102674-102674.
01-06-2021 - Polycystin-2 Is Required for Chondrocyte Mechanotransduction and Traffics to the Primary Cilium in Response to Mechanical Stimulation
Thompson CL, McFie M, Chapple JP, Beales P, Knight MM
International Journal of Molecular Sciences, Mdpi Ag vol. 22 (9), 4313-4313.
21-04-2021 - Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening.
Wu H, Wang Z, Liu S, Meng H, Liu S, Shelton JC, Thompson CL, Fu S et al.
Biochem Biophys Res Commun
15-04-2021 - Corrigendum: Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Thompson CL, Fu S, Heywood HK, Knight MM, Thorpe SD
Frontiers in Bioengineering and Biotechnology, Frontiers Media Sa vol. 9
18-02-2021 - Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer
Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker L, Pearce OMT et al.
02-02-2021 - Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction
Osteoarthritis and Cartilage, Elsevier
01-01-2021
2020
- Solution-Processed Epitaxial Growth of Arbitrary Surface Nanopatterns on Hybrid Perovskite Monocrystalline Thin Films.
Zhang J, Guo Q, Li X, Li C, Wu K, Abrahams I, Yan H, Knight MM et al.
Acs Nano, American Chemical Society
27-08-2020 - Mechanical Stimulation: A Crucial Element of Organ-on-Chip Models
Thompson CL, Fu S, Knight MM, Thorpe SD
Frontiers in Bioengineering and Biotechnology vol. 8
01-01-2020
2019
- Sub-toxic levels of Co2+ are anti-inflammatory and protect cartilage from degradation caused by IL-1β
Fu S, Meng H, Freer F, Kwon J, Shelton JC, Knight MM
Clinical Biomechanics, Elsevier vol. 79
24-12-2019 - Proteoglycan degradation mimics static compression by altering the natural gradients in fibrillar organisation in cartilage
Inamdar SR, Barbieri E, Terrill NJ, Knight MM, Gupta HS
Acta Biomaterialia, Elsevier Bv vol. 97, 437-450.
01-10-2019 - Ciliary exclusion of Polycystin-2 promotes kidney cystogenesis in an autosomal dominant polycystic kidney disease model
Walker RV, Keynton JL, Grimes DT, Sreekumar V, Williams DJ, Esapa C, Wu D, Knight MM et al.
Nature Communications, Springer Science and Business Media Llc vol. 10 (1)
06-09-2019 - Transglutaminase-2 Mediates the Biomechanical Properties of the Colorectal Cancer Tissue Microenvironment that Contribute to Disease Progression
Delaine-Smith R, Wright N, Hanley C, Hanwell R, Bhome R, Bullock M, Drifka C, Eliceiri K et al.
Cancers, Mdpi Ag vol. 11 (5), 701-701.
21-05-2019 - An in vitro investigation of the inflammatory response to the strain amplitudes which occur during high frequency oscillation ventilation and conventional mechanical ventilation
Harris C, Thorpe SD, Rushwan S, Wang W, Thompson CL, Peacock JL, Knight MM, Gooptu B et al.
Journal of Biomechanics, Elsevier Bv vol. 88, 186-189.
01-05-2019 - Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation
Osteoarthritis and Cartilage, Elsevier vol. 27 (7), 1064-1074.
25-03-2019 - Nanoscale Mapping Reveals Functional Differences in Ion Channels Populating the Membrane of Primary Cilia
Cellular Physiology and Biochemistry, Cell Physiol Biochem Press Gmbh and Co Kg vol. 54 (1), 15-26.
10-01-2019 - Lithium chloride triggers primary cilia elongation and inhibits hedgehog signalling in articular chondrocytes
Thompson CL, Poole CA, Knight MM
International Journal of Experimental Pathology vol. 100 (4), A39-A40.
01-01-2019 - Oncometabolite induced primary cilia loss in pheochromocytoma
O’Toole SM, Watson DS, Novoselova TV, Romano LEL, King PJ, Bradshaw TY, Thompson CL, Knight MM et al.
Endocrine-Related Cancer, Bioscientifica vol. 26 (1), 165-180.
01-01-2019
2018
- Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6
Rowson DT, Shelton JC, Screen HRC, Knight MM
Scientific Reports, Springer Nature vol. 8 (1)
23-07-2018 - Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages
Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM, Shelton JC
European Cells and Materials vol. 36, 142-155.
01-07-2018 - Tissue stiffening promotes keratinocyte proliferation through activation of epidermal growth factor signaling
Kenny FN, Drymoussi Z, Delaine-Smith R, Kao AP, Laly AC, Knight MM, Philpott MP, Connelly JT
Journal of Cell Science, The Company of Biologists vol. 131 (10)
15-05-2018 - Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression.
Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM et al.
Acta Biomater vol. 72, 434-446.
09-04-2018 - Deconstruction of a Metastatic Tumor Microenvironment Reveals a Common Matrix Response in Human Cancers
Pearce OMT, Delaine-Smith RM, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D et al.
Cancer Discovery, American Association For Cancer Research (Aacr) vol. 8 (3), 304-319.
01-03-2018
2017
- Chondrocyte expansion is associated with loss of primary cilia and disrupted hedgehog signalling
Thompson CL, Plant JCT, Wann AKT, Bishop CL, Novak P, Mitchison HM, Beales PL, Chapple JP et al.
European Cells and Materials, Forum Multimedia Publishing Llc vol. 34, 128-141.
20-09-2017 - The Secret Life of Collagen: Temporal Changes in Nanoscale Fibrillar Pre-Strain and Molecular Organization during Physiological Loading of Cartilage
Inamdar SR, Knight DP, Terrill NJ, Karunaratne A, Cacho-Nerin F, Knight MM, Gupta HS
Acs Nano, American Chemical Society (Acs) vol. 11 (10), 9728-9737.
17-08-2017 - Topography of calcium phosphate ceramics regulates primary cilia length and TGF receptor recruitment associated with osteogenesis
Zhang J, Dalbay MT, Luo X, Vrij E, Barbieri D, Moroni L, de Bruijn JD, van Blitterswijk CA et al.
Acta Biomaterialia, Elsevier Bv vol. 57, 487-497.
01-07-2017 - Reduced primary cilia length and altered Arl13b expression are associated with deregulated chondrocyte Hedgehog signaling in alkaptonuria
Thorpe SD, Gambassi S, Thompson CL, Chandrakumar C, Santucci A, Knight MM
Journal of Cellular Physiology, Wiley vol. 232 (9), 2407-2417.
31-03-2017 - Smoothened‐antagonists reverse homogentisic acid‐induced alterations of Hedgehog signaling and primary cilium length in alkaptonuria
Gambassi S, Geminiani M, Thorpe SD, Bernardini G, Millucci L, Braconi D, Orlandini M, Thompson CL et al.
Journal of Cellular Physiology, Wiley vol. 232 (11), 3103-3111.
29-03-2017
2016
- Experimental validation of a flat punch indentation methodology calibrated against unconfined compression tests for determination of soft tissue biomechanics
Delaine-Smith RM, Burney S, Balkwill FR, Knight MM
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier Bv vol. 60, 401-415.
01-07-2016 - Chondrocyte dedifferentiation increases cell stiffness by strengthening membrane-actin adhesion
Sliogeryte K, Botto L, Lee DA, Knight MM
Osteoarthritis and Cartilage, Elsevier Bv vol. 24 (5), 912-920.
01-05-2016 - Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon.
Rowson D, Knight MM, Screen HRC
J Orthop Res vol. 34 (12), 2146-2153.
23-03-2016 - IFT88 influences chondrocyte actin organization and biomechanics
Osteoarthritis and Cartilage
01-03-2016 - Differential effects of LifeAct-GFP and actin-GFP on cell mechanics assessed using micropipette aspiration
Sliogeryte K, Thorpe SD, Wang Z, Thompson CL, Gavara N, Knight MM
Journal of Biomechanics, Elsevier Bv vol. 49 (2), 310-317.
01-01-2016
2015
- Cytokine preconditioning of engineered cartilage provides protection against interleukin-1 insult
Tan AR, VandenBerg CD, Attur M, Abramson SB, Knight MM, Bulinski JC, Ateshian GA, Cook JL et al.
Arthritis Research &Amp; Therapy, Springer Science and Business Media Llc vol. 17 (1)
01-12-2015 - Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β
Thompson CL, Patel R, Kelly T-AN, Wann AKT, Hung CT, Chapple JP, Knight MM
Arthritis Research &Amp; Therapy, Springer Science and Business Media Llc vol. 17 (1)
01-12-2015 - Lithium chloride modulates chondrocyte primary cilia and inhibits Hedgehog signaling
Thompson CL, Wiles A, Poole CA, Knight MM
The Faseb Journal, Wiley vol. 30 (2), 716-726.
23-10-2015