Prof Hazel Screen
BEng MRes PhD(Lond) CEng, FIMechE, MIPEM
Publications
- Engineering growth factor gradients to drive spatiotemporal tissue patterning in organ-on-a-chip systems
Journal of Tissue Engineering (2025)
DOI: 10.1177/20417314251326256 - TENDON HEALTH AND DISEASE: EXPLORING THE INTERFASCICULAR NICHE
Orthopaedic Proceedings (2024)
DOI: 10.1302/1358-992x.2024.2.105 - Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment
Biomedical Materials (2023)
DOI: 10.1088/1748-605x/acf976 - Guidelines for ex vivo mechanical testing of tendon
Journal of Orthopaedic Research® (2023)
DOI: 10.1002/jor.25647 - The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by Aging.
Aging and Disease
DOI: 10.14336/AD.2023.0425-1 - Ultrasound Measurement of Local Deformation in the Human Free Achilles Tendon Produced by Dynamic Muscle-Induced Loading: A Systematic Review.
Ultrasound in Medicine and Biology
DOI: 10.1016/j.ultrasmedbio.2023.03.014 - Mild hypercholesterolemia impacts achilles sub-tendon mechanical properties in young rats
BMC Musculoskeletal Disorders
DOI: 10.1186/s12891-023-06375-0 - Development and application of a novel in vivo overload model of the Achilles tendon in rat
Journal of Biomechanics (2023)
DOI: 10.1016/j.jbiomech.2023.111546 - Self-reported bio-psycho-social factors partially distinguish patellar tendinopathy from other knee problems and explain patellar tendinopathy severity in jumping athletes: A case-control study
Physical Therapy in Sport
DOI: 10.1016/j.ptsp.2023.02.009 - The impact of mild hypercholesterolemia on injury repair in the rat patellar tendon.
Journal of Orthopaedic Research
DOI: 10.1002/jor.25546 - Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
Cancers (2023)
DOI: 10.3390/cancers15030635 - Organ-on-a-chip: current gaps and future directions
Biochemical Society Transactions
DOI: 10.1042/BST20200661 - Self-reported bio-psycho-social factors partially distinguish patellar tendinopathy from other knee problems and explain severity in jumping athletes: A case–control study
Physiotherapy
DOI: 10.1016/j.physio.2021.12.052 - Outcome predictors for recovery of patellar tendinopathy in jumping athletes: an international prospective cohort study
BMJ Open
DOI: 10.1136/bmjsem-2022-sportskongres.9 - TENDON STRUCTURE FUNCTION RELATIONSHIPS: INJURY AND THE INTERFASCICULAR MATRIX
TISSUE ENGINEERING PART A - Are Landing Patterns in Jumping Athletes Associated with Patellar Tendinopathy? A Systematic Review with Evidence Gap Map and Meta-analysis
Sports Medicine (2021)
DOI: 10.1007/s40279-021-01550-6 - The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study
PLOS ONE (2021)
DOI: 10.1371/journal.pone.0257269 - Can Achilles tendon xanthoma be distinguished from Achilles tendinopathy using Dixon method MRI? A cross-sectional exploratory study
BMC Musculoskeletal Disorders (2021)
DOI: 10.1186/s12891-021-04494-0 - Structure-function specialisation of the interfascicular matrix in the human achilles tendon
Acta Biomaterialia (2021)
DOI: 10.1016/j.actbio.2021.07.019 - The Impact of Hypercholesterolemia on Tendon Injury Repair
The FASEB Journal (2021)
DOI: 10.1096/fasebj.2021.35.s1.02060 - Elastase treatment of tendon specifically impacts the mechanical properties of the interfascicular matrix
Acta Biomaterialia (2021)
DOI: 10.1016/j.actbio.2021.01.030 - 8 Computational modelling of muscle, tendon, and ligaments biomechanics
DOI: 10.1016/b978-0-12-819531-4.00008-0 - Postnatal mechanical loading drives adaptation of tissues primarily through modulation of the non-collagenous matrix
eLife
DOI: 10.7554/eLife.58075 - Force Transmission Between the Gastrocnemius and Soleus Sub-Tendons of the Achilles Tendon in Rat
Frontiers in Bioengineering and Biotechnology
DOI: 10.3389/fbioe.2020.00700 - Patellar tendinopathy outcome predictors in jumping athletes: feasibility of measures for a cohort study
Physical Therapy in Sport (2020)
DOI: 10.1016/j.ptsp.2020.05.004 - A Recruitment Model of Tendon Viscoelasticity That Incorporates Fibril Creep and Explains Strain-Dependent Relaxation.
Journal of Biomechanical Engineering (2020)
DOI: 10.1115/1.4045662 - An in vitro investigation into the effects of 10Hz cyclic loading on tenocyte metabolism
Scandinavian Journal of Medicine and Science in Sports
DOI: 10.1111/sms.13465 - Insights into the micromechanics of stress-relaxation and creep behaviours in the aortic valve.
J Mech Behav Biomed Mater
DOI: 10.1016/j.jmbbm.2019.02.011 - Novel glycopolymer-based biomaterials for tissue engineering
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY - Guided Cell Attachment via Aligned Electrospinning of Glycopolymers
Macromolecular Bioscience
DOI: 10.1002/mabi.201800293 - Magnetic resonance elastography in nonlinear viscoelastic materials under load
Biomechanics and Modeling in Mechanobiology (2018)
DOI: 10.1007/s10237-018-1072-1 - Postnatal Development of the Functional Specialization of the Equine Superficial Digital Flexor Tendon
Veterinary and Comparative Orthopaedics and Traumatology (2018)
DOI: 10.1055/s-0038-1668213 - Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6
Scientific Reports (2018)
DOI: 10.1038/s41598-018-29502-7 - Tendon pathology: Have we missed the first step in the development of pathology?
J Appl Physiol (1985)
DOI: 10.1152/japplphysiol.00002.2018 - Effects of cell adhesion motif, fiber stiffness, and cyclic strain on tenocyte gene expression in a tendon mimetic fiber composite hydrogel
Biochemical and Biophysical Research Communications
DOI: 10.1016/j.bbrc.2018.03.203 - Pre- and post-natal development of the tendon inter-fascicular matrix and fascicles in the equine superficial digital flexor tendon and common digital extensor tendon
Osteoarthritis and Cartilage
DOI: 10.1016/j.joca.2018.02.783 - Structure and collagen crimp patterns of functionally distinct equine tendons, revealed by quantitative polarised light microscopy (qPLM)
Acta Biomaterialia
DOI: 10.1016/j.actbio.2018.01.034 - Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing
Scientific Reports
DOI: 10.1038/s41598-017-09995-4 - The relative compliance of energy-storing tendons may be due to the helical fibril arrangement of their fascicles
Journal of the Royal Society Interface
DOI: 10.1098/rsif.2017.0261 - Fascicles and the interfascicular matrix show decreased fatigue life with ageing in energy storing tendons
Acta Biomaterialia
DOI: 10.1016/j.actbio.2017.03.024 - A2B-Miktoarm Glycopolymer Fibers and Their Interactions with Tenocytes
Bioconjugate Chemistry
DOI: 10.1021/acs.bioconjchem.7b00279 - Novel models of late onset, progressive osteoarthritis caused by point mutations in the two alpha chains of collagen type I
Osteoarthritis and Cartilage
DOI: 10.1016/j.joca.2017.02.101 - Recapitulating the Micromechanical Behavior of Tension and Shear in a Biomimetic Hydrogel for Controlling Tenocyte Response
Advanced Healthcare Materials
DOI: 10.1002/adhm.201601095 - Development of a two-stage gene selection method that incorporates a novel hybrid approach using the cuckoo optimization algorithm and harmony search for cancer classification
Journal of Biomedical Informatics
DOI: 10.1016/j.jbi.2017.01.016 - A transverse isotropic viscoelastic constitutive model for aortic valve tissue
Royal Society Open Science
DOI: 10.1098/rsos.160585 - Cyclic loading leads to primary cilia disassembly in human tenocytes
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY - Do the sub-bundles within the Achilles tendon originating from distinct muscle bellies differ in structural and mechanical properties?
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY - Structural Building Blocks of Soft Tissues: Tendons and Heart Valves (2016)
DOI: 10.1007/978-3-319-45071-1_1 - Fascicles and the interfascicular matrix show adaptation for fatigue resistance in energy storing tendons
Acta Biomaterialia
DOI: 10.1016/j.actbio.2016.06.012 - Nomenclature of the tendon hierarchy: An overview of inconsistent terminology and a proposed size-based naming scheme with terminology for multi-muscle tendons
Journal of Biomechanics
DOI: 10.1016/j.jbiomech.2016.06.028 - The use of medical infrared thermography in the detection of tendinopathy: a systematic review
Physical Therapy Reviews (2016)
DOI: 10.1080/10833196.2016.1223575 - Tendon Structure and Composition
Advances in Experimental Medicine and Biology (2016)
DOI: 10.1007/978-3-319-33943-6_1 - The effect of gradations in mineral content, matrix alignment, and applied strain on human mesenchymal stem cell morphology within collagen biomaterials
Advanced healthcare materials
DOI: 10.1002/adhm.201600181 - Distribution of proteins within different compartments of tendon varies according to tendon type
Journal of Anatomy (2016)
DOI: 10.1111/joa.12485 - Zonal variation in primary cilia elongation correlates with localized biomechanical degradation in stress deprived tendon.
J Orthop Res
DOI: 10.1002/jor.23229 - Anatomical heterogeneity of tendon: Fascicular and interfascicular tendon compartments have distinct proteomic composition
Scientific Reports (2016)
DOI: 10.1038/srep20455 - Elastin is more abundant in energy storing tendons and is localised to the tendon interfascicular matrix
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY - Energy storing and positional human tendons: mechanics and changes with ageing
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY - In vivo biological response to extracorporeal shockwave therapy in human tendinopathy
eCells & Materials (2015)
DOI: 10.22203/ecm.v029a20 - Tendon Functional Extracellular Matrix
Journal of Orthopaedic Research® (2015)
DOI: 10.1002/jor.22818 - Tendon extracellular matrix damage, degradation and inflammation in response to in vitro overload exercise
Journal of Orthopaedic Research® (2015)
DOI: 10.1002/jor.22879 - The interfascicular matrix enables fascicle sliding and recovery in tendon, and behaves more elastically in energy storing tendons
Journal of the Mechanical Behavior of Biomedical Materials (2015)
DOI: 10.1016/j.jmbbm.2015.04.009 - Eccentric and Concentric Exercise of the Triceps Surae: An in Vivo Study of Dynamic Muscle and Tendon Biomechanical Parameters
Journal of Applied Biomechanics
DOI: 10.1123/jab.2013-0284 - Eccentric and Concentric Exercise of the Triceps Surae: An in Vivo Study of Dynamic Muscle and Tendon Biomechanical Parameters.
J Appl Biomech
DOI: 10.1123/JAB.2013-0284 - Eccentric and concentric exercise of the triceps surae: an in vivo study of dynamic muscle and tendon biomechanical parameters.
J Appl Biomech
DOI: 10.1123/JAB.2013-0284 - The effectiveness of extracorporeal shock wave therapy in lower limb tendinopathy: a systematic review.
Am J Sports Med
DOI: 10.1177/0363546514531911 - Science in brief: Recent advances into understanding tendon function and injury risk
Equine Veterinary Journal (2015)
DOI: 10.1111/evj.12346 - Cancer classification using a novel gene selection approach by meansof shuffling based on data clustering with optimization
Applied Soft Computing
DOI: 10.1016/j.asoc.2015.06.015 - Chapter 1 Tendon Physiology and Mechanical Behavior Structure–Function Relationships
DOI: 10.1016/b978-0-12-801590-2.00001-6 - Tendon Physiology and Mechanical Behavior: Structure-Function Relationships
DOI: 10.1016/B978-0-12-801590-2.00001-6 - Tendon overload results in alterations in cell shape and increased markers of inflammation and matrix degradation
Scandinavian Journal of Medicine and Science in Sports (2014)
DOI: 10.1111/sms.12333 - Early stage fatigue damage occurs in bovine tendon fascicles in the absence of changes in mechanics at either the gross or micro-structural level.
J Mech Behav Biomed Mater
DOI: 10.1016/j.jmbbm.2014.06.005 - Proteomic analysis reveals age-related changes in tendon matrix composition, with age- and injury-specific matrix fragmentation.
J Biol Chem
DOI: 10.1074/jbc.M114.566554 - 104 Characterisation Of The Proteome Of The Tendon Interfascicular Matrix
British Journal of Sports Medicine (2014)
DOI: 10.1136/bjsports-2014-094114.103 - 78 Human Tenocyte Metabolism Under Pathological And Physiological Loading Conditions
British Journal of Sports Medicine (2014)
DOI: 10.1136/bjsports-2014-094114.77 - 89 Primary Cilia In Tenocytes From The Inter-fascicular Matrix And The Fascicular Matrix
British Journal of Sports Medicine (2014)
DOI: 10.1136/bjsports-2014-094114.88 - 98 Early Inflammatory Response Of Tenocytes To Overload
British Journal of Sports Medicine (2014)
DOI: 10.1136/bjsports-2014-094114.97 - Achillessehnentendinopathie
Sportphysio (2014)
DOI: 10.1055/s-0034-1387914 - Effect of fatigue loading on structure and functional behaviour of fascicles from energy-storing tendons.
Acta Biomater
DOI: 10.1016/j.actbio.2014.04.008 - The effects of extracorporeal shockwave therapy on matrix metalloprotease activity in tendinopathy (1046.8)
The FASEB Journal (2014)
DOI: 10.1096/fasebj.28.1_supplement.1046.8 - Fascicles from energy-storing tendons show an age-specific response to cyclic fatigue loading
Journal of the Royal Society Interface
DOI: 10.1098/rsif.2013.1058 - Effect of Fatigue Loading on Tendon Fascicle Extension Mechanisms (2014)
DOI: 10.1115/sbc2013-14009 - Energy Storing and Positional Tendon Fascicles Exhibit Different Fatigue Behaviour (2014)
DOI: 10.1115/sbc2013-14018 - Advances in the understanding of tendinopathies: A report on the Second Havemeyer Workshop on equine tendon disease
EQUINE VETERINARY JOURNAL
DOI: 10.1111/evj.12128 - Fatigue loading causes a reduction in the ability of tendon fascicles to recoil
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY - Functionally distinct tendon fascicles exhibit different creep and stress relaxation behaviour.
Proc Inst Mech Eng H
DOI: 10.1177/0954411913509977 - Matrix damage as a result of cyclic creep loading occurs in the absence of changes in tendon mechanics at either the gross or micro-structural level
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY - Fatigue loading of tendon.
Int J Exp Pathol
DOI: 10.1111/iep.12037 - Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return.
Acta Biomater
DOI: 10.1016/j.actbio.2013.05.004 - The role of the non-collagenous matrix in tendon function.
Int J Exp Pathol
DOI: 10.1111/iep.12027 - GAG depletion increases the stress-relaxation response of tendon fascicles, but does not influence recovery.
Acta Biomater
DOI: 10.1016/j.actbio.2013.02.028 - Response to letter to the editor: "End effects in mechanical testing of biomaterials"
Journal of Biomechanics
DOI: 10.1016/j.jbiomech.2012.12.020 - Cyclic loading of tendon fascicles using a novel fatigue loading system increases interleukin-6 expression by tenocytes
Scandinavian Journal of Medicine and Science in Sports
DOI: 10.1111/j.1600-0838.2011.01410.x - Capacity for sliding between tendon fascicles decreases with ageing in injury prone equine tendons: a possible mechanism for age-related tendinopathy?
Eur Cell Mater
DOI: 10.22203/ecm.v025a04 - Helical fascicles in energy storing tendons: a mechanism for efficient recoil?
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY - Helical sub-structures in energy-storing tendons provide a possible mechanism for efficient energy storage and return
Acta Biomaterialia
DOI: 10.1016/j.actbio.2013.05.004 - Microstructural stress relaxation mechanics in functionally different tendons
Medical Engineering and Physics
DOI: 10.1016/j.medengphy.2012.04.004 - Response to letter to the editor: "End effects in mechanical testing of biomaterials"
Journal of Biomechanics
DOI: 10.1016/j.jbiomech.2012.12.020 - The effects of extracorporeal shock wave therapy (ESWT) on type I collagen synthesis in the Achilles tendon: an intervention study on healthy participants
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY - The fatigue behaviour of functionally distinct bovine tendons
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY
