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Simulation of strain fields in bone grafts with multi-scale porosity to investigate guided bone regeneration

Principal investigator: Mouna Chetehouna
Co-investigator(s): and Karin HING

The aim of this project is to develop and validate a multiscale 3D model for porous ceramic scaffolds with a hierarchical pore structure, in order to test the hypothesis that the phenomenon of osteoinductivity in synthetic bone grafts is mediated by local biomechanics. The model would be validated using empirical data obtained from a series of CT scans of implanted granule masses to create 3D strain maps to link directly with histomorphometric and histological analysis.