Development of a synovium-chondrocyte organ-on-a-chip model with integrated biomechanical stimulation

Principal investigator: Hazel SCREEN
Co-investigator(s): and Martin KNIGHT
Funding source(s): EPSRC OA Tech Network plus Pump-Priming Project Grant
 Start: 01-07-2019  /  End: 31-12-2019
 Amount: £9,068
We plan to develop an organ-on-a chip microfluidic model to investigate the effects of mechanical stimulation on the interaction between musculoskeletal cells within the joint. This chip will incorporate the multiple cell types seen in cartilage and the surrounding synovial environment to mimic human tissue architecture, cellular microenvironment and signalling.