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Research

Epigenomics of endothelial cells

Principal investigator: Rob KRAMS
Funding source(s): British Heart Foundation
We study whole genomics of endothelial cells obtained from atherosclerotic blood vessels from mice and pigs. These cells are isolated with laser capture on basis of shear stress and strain profiles. RNAseq is performed to obtain differential mRNA and microRNA expression. Extensive bioinformatics is performed for inference of gene networks and the interaction with microRNA