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Research

Development of a 3D Perfusion System to Monitor Response of Osteoblast-like Cells Incubated on Synthetic Bone Graft Substitute Granules with Varied Hierarchical Porosities under Dynamic Conditions

Principal investigator: Karin HING
Co-investigator(s): Simon Rawlinson
Funding source(s): E.P.S.R.C.
 Start: 01-02-2011  /  End: 01-02-2016
Directly incurred staff: Navinder Kaur Chana

The aim of this thesis was to develop an in vitro system with which to characterise ionic exchange and monitor cell response to real granular synthetic bone graft substitute materials with a hierarchical pore structure, within a truly 3D environment to enable systematic investigation of the mechanisms by which scaffold structure can impact on graft bioactivity.