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Division of Bioengineering

Development of mechanically enhanced osteoinductive synthetic bone graft substitutes

Principal investigator:Karin HING
Funding source(s):Apatech Ltd
 Start: 01-10-2017  /  End: 31-03-2021
 Amount: £87500
SEMS divisions:
The aim of this project is to develop and test a series of bone graft substitutes with novel pore structures using a perfusion based bioreactor system with flow to waste and closed loop capabilities, that is also able to subject real bone graft substitute granules to direct mechanical perturbation. This system has been validated using human mesenchymal stem cells seeded on BGS with varied strut porosity and will be further optimised to enable screening of new structures.