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Dr Pamela Swiatlowska

 

Research Overview

mechanobiology, heart disease, atherosclerosis, cardiomyocytes, smooth muscle cells, bioengineering, bioprinting

Publication list

  • Swiatlowska P*, Sit B*, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Shanahan C, Jones G, Yu C.-h., Iskratsch T, “Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching and cofilin dependent podosome formation”. bioRxiv doi.org/10.1101/2020.12.27.424498, Science Advances 2021 (under review)
  • Sri-Ranjan K, Sanchez-Alonso JL, Swiatlowska P, Rothery S, Novak P, Gerlach S, Koeninger D, Hoffmann B, Merkel R, Stevens MM, Sun S, Gorelik J, Braga VMM. "Intrinsic cell rheology drives junction maturation". Nature Communications 2021 (in revision)
  • Swiatlowska P, Iskratsch T.”An updated look at mechanical forces in cardiovascular development, physiology and disease”. Biophysical Reviews Editorial 2021, doi.org/10.1007/s12551-021-00842-5
  • Swiatlowska P, Iskratsch T.”Tools for studying cardiomyocyte mechanics and mechanosensing across the scales.” Biophysical Reviews 2021, doi.org/10.1007/s12551-021-00837-2
  • Swiatlowska P and Iskratsch T. “Announcing the call for the Special Issue on “Cardiovascular mechanobiology-a special issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology and disease”. Biophysical Reviews 2021, doi.org/10.1007/s12551-021-00800-1
  • Swiatlowska P, Delmar M. “Membrane Stiffness as a Function of Plakophilin-2 Expression: Implications to Arrhythmogenic Right Ventricular Cardiomyopathy”. Circulation. 2020 (conference paper); 142: A13664 doi.org/10.1161/circ.142.suppl_3.13664
  • Sintou A, el Rifai S, Mansfield C, Rothery S, Sanchez Alonso JL, Narodden S, Sharma K, Ferraro E, Hasham MG, Swiatlowska P et al.,’’Mediastinal Lymphadenopathy, Class-Switched Auto-Antibodies and Myocardial Immune-Complexes During Heart Failure Rodents and Humans”. Frontiers Cell and Developmental Biology 2020, doi.org/10.3389/fcell.2020.00695
  • Swiatlowska P et al., „Short-term Angiotensin II treatment regulates cardiac nanomechanics via microtubule modifications”. Nanoscale 2020, doi:10.1039/d0nr02474k
  • Poulet C, Sanchez-Alonso JL, Swiatlowska P et al., “Junctophilin-2 tethers T-tubules and recruits functional L-type calcium channels to lipid rafts in adult cardiomyocytes” Cardiovascular Research 2020 doi: 10.1093/cvr/cvaa033
  • Swiatlowska P et al., “Microtubules regulate cardiomyocyte transversal Young’s modulus” PNAS 2020 doi.org/10.1073/pnas.1917171117        
  • Swiatlowska P, Sanchez-Alonso J, Wright P, Bello S, Novak P, Gorelik J et al., “Single cell mechanics in failing heart: role of microtubules and mitochondria re-arrangement” 2019 ESC (conference paper), Publisher: WILEY, Pages: 316-316, ISSN: 1388-9842
  • Brezovjakova H, Noor NM, Swiatlowska P et al., “Junction Mapper is a novel computer vision tool to decipher cell-cell contact phenotypes” eLife 2019, doi.10.7554/eLife.45413
  •  Swiatlowska P et al., “Cardiomyocyte-myofibroblast contact dynamism modulated by connexin” FASEB 2019, doi.org/10.1096/fj.201802740RR
  • Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P et al., “Activation of the pluripotency factor OCT4 in smooth muscle cells is atheroprotective” Nature Medicine 2016, doi:10.1038/nm.4109
  • Gomez D, Swiatlowska P et al., “Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory” ATVB 2015, doi:10.1161/ATVBAHA.115305044
  • Shankman LS, Gomez D, Cherepanova OA, Salomon M, Alencar GF, Haskins RM, Swiatlowska P, et al., “KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis” Nature Medicine 2015; doi:10.1038/nm.3866