Prof Julia Shelton
BA(Cantab) PhD(Lond)

 

All Publications

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2023

  • Influence of Taper surface topographies on contact deformation and stresses
    Diaz-Lopez RA, Wen PH, Shelton JC
    Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 148 
    28-10-2023

2022

  • Influence of taper design and loading on taper micromotion
    Diaz-Lopez RA, Wen PH, Shelton JC
    Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 128 
    29-01-2022

2021

  • Sub-toxic levels of cobalt ions impair mechanostranduction via HDAC6-depedent primary cilia shortening.
    Wu H, Wang Z, Liu S, Meng H, Liu S, Shelton JC, Thompson CL, Fu S et al.
    Biochem Biophys Res Commun 
    15-04-2021

2020

  • Activation of synovial fibroblasts from patients at revision of their metal-on-metal total hip arthroplasty
    Xu J, Yang J, Chen J, Zhang X, Wu Y, Hart A, Nyga A, Shelton JC
    Particle and Fibre Toxicology, Biomed Central vol. 17 (1), 42-42.  
    27-08-2020
  • 3D models of chondrocytes within biomimetic scaffolds: Effects of cell deformation from loading regimens
    Di Federico E, Bader DL, Shelton JC
    Clinical Biomechanics, Elsevier Bv 
    07-02-2020

2019

  • Sub-toxic levels of Co2+ are anti-inflammatory and protect cartilage from degradation caused by IL-1β
    Fu S, Meng H, Freer F, Kwon J, Shelton JC, Knight MM
    Clinical Biomechanics, Elsevier vol. 79 
    24-12-2019
  • An electrochemical study of acrylate bone adhesive permeability and selectivity change during in vitro ageing: a model approach to the study of biomaterials and membrane barriers
    VADGAMA PM
    Analytica Chimica Acta, Elsevier Masson 
    04-03-2019

2018

  • Mechanical loading induces primary cilia disassembly in tendon cells via TGFβ and HDAC6
    Rowson DT, Shelton JC, Screen HRC, Knight MM
    Scientific Reports, Springer Nature vol. 8 (1) 
    23-07-2018
  • Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages
    Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM, Shelton JC
    European Cells and Materials vol. 36, 142-155.  
    01-07-2018
  • Prediction of taper performance using quasi static FE models: The influence of loading and taper clearance and trunnion length
    SHELTON JC
    Journal of Biomedical Materials Research: Part B - Applied Biomaterials 
    10-04-2018
  • Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated down-regulation of RhoA expression.
    Xu J, Yang J, Nyga A, Ehteramyan M, Moraga A, Wu Y, Zeng L, Knight MM et al.
    Acta Biomater vol. 72, 434-446.  
    09-04-2018
  • Cobalt (II) ions and nanoparticles induce macrophage retention by ROS-mediated downregulation of RhoA expression
    SHELTON JC
    Acta Biomaterialia, Elsevier vol. 72, 434-446.  
    09-04-2018

2017

  • Simulator Study of MOM using Steep-cup Flexion - A Clinically Relevant Incorporation of Intermittent Edge-loading
    Clarke I, Shelton J, Bowsher J, Savisaar C, Donaldson T
    Reconstructive Review, Portico vol. 7 (3), 190-190.  
    01-10-2017
  • Complex mechanical conditioning of cell-seeded agarose constructs can influence chondrocyte biosynthetic activity
    Di Federico E, SHELTON JC, Bader DL
    Biotechnology and Bioengineering, Wiley 
    23-03-2017

2016

  • Measurement outcomes from hip simulators
    de Villiers D, Shelton JC
    Proceedings of The Institution of Mechanical Engineers Part H Journal of Engineering in Medicine, Sage Publications vol. 230 (5), 398-405.  
    17-02-2016

2015

  • The increase in cobalt release in metal-on-polyethylene hip bearings in tests with third body abrasives
    de Villiers D, Traynor A, Collins SN, Shelton JC
    Proceedings of The Institution of Mechanical Engineers Part H Journal of Engineering in Medicine, Sage Publications vol. 229 (9), 611-618.  
    15-07-2015
  • Chromium nitride coating for large diameter metal-on-polyethylene hip bearings under extreme adverse hip simulator conditions
    de Villiers D, Traynor A, Collins SN, Banfield S, Housden J, Shelton JC
    Wear, Elsevier vol. 328, 363-368.  
    01-04-2015

2014

  • Design and validation of an in vitro loading system for the combined application of cyclic compression and shear to 3D chondrocytes-seeded agarose constructs.
    Di Federico E, Bader DL, Shelton JC
    Med Eng Phys vol. 36 (4), 534-540.  
    01-04-2014

2013

  • Microstructural stress relaxation mechanics in functionally different tendons
    Screen HRC, Toorani S, Shelton JC
    Medical Engineering and Physics vol. 35 (1), 96-102.  
    01-01-2013
  • Microstructural stress relaxation mechanics in functionally different tendons.
    Screen HRC, Toorani S, Shelton JC
    Med Eng Phys vol. 35 (1), 96-102.  
    01-01-2013

2012

  • Simple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator test
    Lu F, Royle M, Lali FV, Hart AJ, Collins S, Housden J, Shelton JC
    Journal of Materials Science: Materials in Medicine vol. 23 (4), 891-901.  
    01-04-2012
  • Deformation of uncemented metal acetabular cups following impaction: Experimental and finite element study
    Hothi HS, Busfield JJC, Shelton JC
    Computer Methods in Biomechanics and Biomedical Engineering 
    01-01-2012
  • Simple isolation method for the bulk isolation of wear particles from metal on metal bearing surfaces generated in a hip simulator test
    Lu F, Royle M, Lali FV, Hart AJ, Collins S, Housden J, Shelton JC
    Journal of Materials Science: Materials in Medicine, 1-11.  
    01-01-2012

2011

  • Quantifying the wear of acetabular cups using coordinate metrology
    Wear vol. 271 (7-8), 1086-1092.  
    18-07-2011
  • Explicit finite element modelling of the impaction of metal press-fit acetabular components
    Hothi HS, Busfield JJC, Shelton JC
    Proceedings of The Institution of Mechanical Engineers Part H Journal of Engineering in Medicine vol. 225 (3), 303-314.  
    01-03-2011

2010

  • Challenges of developing engineering students' writing through peer assessment
    McConlogue T, Mueller J, Shelton J
    Engineering Education 2010 Inspiring The Next Generation of Engineers Ee 2010 
    01-12-2010
  • Functional analysis of tenocytes gene expression in tendon fascicles subjected to cyclic tensile strain
    Maeda E, Fleischmann C, Mein CA, Shelton JC, Bader DL, Lee DA
    Connective Tissue Research vol. 51 (6), 434-444.  
    01-12-2010

2009

  • Effect of intermittent cyclic tensile strain on collagen synthesis by tenocytes in isolated fascicles
    Maeda E, Shelton JC, Bader DL, Lee DA
    Journal of Biomechanical Science and Engineering vol. 4 (4), 510-517.  
    01-12-2009
  • Influence of cup orientation on the wear performance of metal-on-metal hip replacements
    Angadji A, Royle M, Collins SN, Shelton JC
    Proceedings of The Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine vol. 223 (4), 449-457.  
    01-04-2009
  • Differential regulation of gene expression in isolated tendon fascicles exposed to cyclic tensile strain in vitro
    Maeda E, Shelton JC, Bader DL, Lee DA
    Journal of Applied Physiology vol. 106 (2), 506-512.  
    01-02-2009
  • Cell-generated forces influence the viability, metabolism and mechanical properties of fibroblast-seeded collagen gel constructs.
    Berry CC, Shelton JC, Lee DA
    J Tissue Eng Regen Med vol. 3 (1), 43-53.  
    01-01-2009

2008

  • Affect of cup positioning on the wear performance and wear particles from metal-on-metal hip replacements
    Angadji A, Grossmann H, Royle M, Collins SN, Shelton JC
    8th World Biomaterials Congress 2008 vol. 2 
    01-12-2008
  • Characterizing structure-function relationships in tendon
    Toorani S, Shelton JC, Screen HRC
    8th World Biomaterials Congress 2008 vol. 2 
    01-12-2008
  • Collagen synthesis by tenocytes in fascicles subjected to intermittent cyclic strain
    Maeda E, Shelton JC, Bader DL, Lee DA
    European Cells and Materials vol. 16 (SUPPL. 3) 
    01-07-2008
  • Development and validation of a novel bioreactor system for load- and perfusion-controlled tissue engineering of chondrocyte-constructs
    Schulz RM, Wüstneck N, Van Donkelaar CC, Shelton JC, Bader A
    Biotechnology and Bioengineering vol. 101 (4), 714-728.  
    11-01-2008
  • Configuration of anchorage holes affects cemented fixation of the acetabular component in total hip replacement: an in vitro study.
    Mootanah R, Jarrett P, Ingle P, Cheah K, Dowell JK, Shelton JC
    Technol Health Care vol. 16 (1), 19-30.  
    01-01-2008

2007

  • Configuration of anchorage holes affects fixation of the acetabular component in cemented total hip replacement--a finite element study.
    Mootanah R, Dowell JK, Cheah K, Ingle P, Shelton JC
    Comput Methods Biomech Biomed Engin vol. 10 (6), 439-445.  
    01-12-2007
  • Time dependence of cyclic tensile strain on collagen production in tendon fascicles.
    Maeda E, Shelton JC, Bader DL, Lee DA
    Biochem Biophys Res Commun vol. 362 (2), 399-404.  
    19-10-2007

2006

  • The influence of swelling and matrix degradation on the microstructural integrity of tendon.
    Screen HRC, Chhaya VH, Greenwald SE, Bader DL, Lee DA, Shelton JC
    Acta Biomater vol. 2 (5), 505-513.  
    01-09-2006
  • 'Severe' wear challenge to 'as-cast' and 'double heat-treated' large-diameter metal-on-metal hip bearings
    Bowsher JG, Nevelos J, Williams PA, Shelton JC
    P I Mech Eng H vol. 220 (H2), 135-143.  
    01-02-2006
  • Metal-on-metal hip simulator study of increased wear particle surface area due to 'severe' patient activity.
    Bowsher JG, Hussain A, Williams PA, Shelton JC
    Proc Inst Mech Eng H vol. 220 (2), 279-287.  
    01-02-2006

2005

  • Cyclic mechanical conditioning of isolated tendon fascicles results in an upregulation of collagen production
    Screen HRC, Bader DL, Shelton JC, Lee DA
    Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 193-194.  
    01-12-2005
  • Cyclic tensile strain upregulates collagen synthesis in isolated tendon fascicles.
    Screen HRC, Shelton JC, Bader DL, Lee DA
    Biochem Biophys Res Commun vol. 336 (2), 424-429.  
    21-10-2005
  • The influence of noncollagenous matrix components on the micromechanical environment of tendon fascicles.
    Screen HRC, Shelton JC, Chhaya VH, Kayser MV, Bader DL, Lee DA
    Ann Biomed Eng vol. 33 (8), 1090-1099.  
    01-08-2005
  • Blood flow and damage by the roller pumps during cardiopulmonary bypass
    Mulholland JW, Shelton JC, Luo XY
    J Fluid Struct vol. 20 (1), 129-140.  
    01-01-2005

2004

  • Effect of ion implantation on the tribology of metal-on-metal hip prostheses.
    Bowsher JG, Hussain A, Williams P, Nevelos J, Shelton JC
    J Arthroplasty vol. 19 (8 Suppl 3), 107-111.  
    01-12-2004
  • Local Strain Measurement within Tendon
    Bader DL, Shelton JC, Lee DA, SCREEN HRC
    Strain vol. 40 (4), 157-163.  
    01-11-2004
  • Confocal analysis of local and cellular strains in chondrocyte-agarose constructs subjected to mechanical shear.
    Sawae Y, Shelton JC, Bader DL, Knight MM
    Ann Biomed Eng vol. 32 (6), 860-870.  
    01-06-2004
  • Investigation of the molecular nature of low-molecular-mass cobalt(II) ions in isolated osteoarthritic knee-joint synovial fluid.
    Silwood CJL, Chikanza IC, Tanner KE, Shelton JC, Bowsher JG, Grootveld M
    Free Radic Res vol. 38 (6), 561-571.  
    01-06-2004
  • An investigation into the effects of the hierarchical structure of tendon fascicles on micromechanical properties.
    Screen HRC, Lee DA, Bader DL, Shelton JC
    Proc Inst Mech Eng H vol. 218 (2), 109-119.  
    01-01-2004

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