The regulation of mechanosensing in healthy and atherosclerotic VSMC

Principal investigator: Thomas ISKRATSCH
Funding source(s): BHF British Heart Foundation
 Start: 01-12-2020  /  End: 30-11-2023
 Amount: £238,021

Vascular smooth muscle cellsplay a central role in the onset and progression of many cardiovascular diseases, from atherosclerosis to vascular injury, where their migration, matrix secretion, or degradation functions are deregulated. Here we are investigating how the phenotypic switch is regulated through physical/mechanical stimuli.