Research

Mechano-regulation of genome function to direct stem cell fate

Principal investigator: David LEE
Co-investigator(s): and
This project addresses the concept that the nucleus acts as a sensor for mechanical stimuli. By characterising biophysical and epigenetic changes as stem cells differentiate, we will identify pathways responsible for the alteration of cellular mechanosensitivity. These can then be targeted to repair defective mechanosensitivity in diseased or aged cells.