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Research

A platform to study tenocyte mechanotransduction

Principal investigator: Hazel SCREEN
Funding source(s): National Institutes of Health R21
 Start: 01-06-2012  /  End: 31-05-2014
Investigating cell mechanotransduction requires a highly controlled cell environment within which the effects of mechanical stimuli can be characterised. This project developed a hydrogel scaffold material able to apply physiologically relevant strains to tenocytes and specifically investigated the effects of different peptides for cell attachment, their effects of integrin binding. We showed how altering the integrins linking cell and matrix influenced cell metabolism and matrix turnover.