Dr Stefaan Verbruggen
BEng, PhD, FHEA
Key Publications
- A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells
Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR and Knight MM
Advanced Science, Wiley vol. 11 (2), 2305842-2305842.
15-11-2023 - Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling
Schurman CA, Verbruggen SW and Alliston T
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 118 (25), e2023999118-e2023999118.
14-06-2021 - Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM
Cancers, Mdpi vol. 13 (12)
10-06-2021 - Stresses and strains on the human fetal skeleton during development
Verbruggen SW, Kainz B, Shelmerdine SC, Hajnal JV, Rutherford MA, Arthurs OJ, Phillips ATM and Nowlan NC
Journal of The Royal Society Interface, The Royal Society vol. 15 (138)
01-01-2018 - Function and failure of the fetal membrane: Modelling the mechanics of the chorion and amnion.
Verbruggen SW, Oyen ML, Phillips ATM and Nowlan NC
Plos One vol. 12 (3), e0171588-e0171588.
28-03-2017
All Publications
2025
- Altered vertebral biomechanical properties in prostate cancer patients following androgen deprivation therapy
Gibson FG, Paggiosi MA, Handforth C, Brown JE, Li X, Dall'Ara E and Verbruggen SW
Bone, Elsevier vol. 195
19-03-2025
2024
- Air Pollution and Osteoporosis
Allen O, Knight MM and Verbruggen SW
Current Osteoporosis Reports, Springer Science and Business Media Llc
20-09-2024 - Analytical and computational studies predict negligible risk of cell death from eddy generation off flat surfaces in cell culture flow systems
Morley EJ, Brockett CL and Verbruggen SW
Frontiers in Bioengineering and Biotechnology, Frontiers vol. 12, 1340653-1340653.
07-08-2024 - Utilizing 3D Models to Unravel the Dynamics of Myeloma Plasma Cells’ Escape from the Bone Marrow Microenvironment
Verbruggen SW, Freeman CL and Freeman FE
Cancers, Mdpi vol. 16 (5)
22-02-2024 - Role of the osteocyte in bone metastasis – The importance of networking
Verbruggen SW
Journal of Bone Oncology, Elsevier vol. 44
17-01-2024
2023
- A Novel Primary Cilium‐Mediated Mechanism Through which Osteocytes Regulate Metastatic Behavior of Both Breast and Prostate Cancer Cells
Verbruggen SW, Nolan J, Duffy MP, Pearce OMT, Jacobs CR and Knight MM
Advanced Science, Wiley vol. 11 (2), 2305842-2305842.
15-11-2023 - Osteocytes and Primary Cilia
Verbruggen SW, Sittichokechaiwut A and Reilly GC
Current Osteoporosis Reports, Springer
08-09-2023 - In silico assessment of the bone regeneration potential of complex porous scaffolds
Asbai-Ghoudan R, Nasello G, Pérez MÁ, Verbruggen SW, Ruiz de Galarreta S and Rodriguez-Florez N
Computers in Biology and Medicine, Elsevier vol. 165
14-08-2023 - Osteoclastogenesis Requires Primary Cilia Disassembly and Can Be Inhibited by Promoting Primary Cilia Formation Pharmacologically
Sutton MM, Duffy MP, Verbruggen SW and Jacobs CR
Cells Tissues Organs, Karger Publishers vol. 213 (3), 235-244.
22-05-2023 - Organ-on-a-Chip and Microfluidic Platforms for Oncology in the UK
Nolan J, Pearce OMT, Screen HRC, Knight MM and Verbruggen SW
Cancers, Mdpi vol. 15 (3)
19-01-2023
2021
- Disrupted osteocyte connectivity and pericellular fluid flow in bone with aging and defective TGF-β signaling
Schurman CA, Verbruggen SW and Alliston T
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 118 (25), e2023999118-e2023999118.
14-06-2021 - Mechanical Stimulation Modulates Osteocyte Regulation of Cancer Cell Phenotype
Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM
Cancers, Mdpi vol. 13 (12)
10-06-2021
2018
- European Society of Biomechanics S.M. Perren Award 2018: Altered biomechanical stimulation of the developing hip joint in presence of hip dysplasia risk factors
Verbruggen SW, Kainz B, Shelmerdine SC, Arthurs OJ, Hajnal JV, Rutherford MA, Phillips ATM and Nowlan NC
Journal of Biomechanics, Elsevier vol. 78, 1-9.
20-07-2018 - Stresses and strains on the human fetal skeleton during development
Verbruggen SW, Kainz B, Shelmerdine SC, Hajnal JV, Rutherford MA, Arthurs OJ, Phillips ATM and Nowlan NC
Journal of The Royal Society Interface, The Royal Society vol. 15 (138)
01-01-2018
2017
- Function and failure of the fetal membrane: Modelling the mechanics of the chorion and amnion.
Verbruggen SW, Oyen ML, Phillips ATM and Nowlan NC
Plos One vol. 12 (3), e0171588-e0171588.
28-03-2017 - Ontogeny of the Human Pelvis
Verbruggen SW and Nowlan NC
The Anatomical Record, Wiley vol. 300 (4), 643-652.
15-03-2017
2016
- In silico bone mechanobiology: modeling a multifaceted biological system
Giorgi M, Verbruggen SW and Lacroix D
Wires Mechanisms of Disease, Wiley vol. 8 (6), 485-505.
07-09-2016 - Mechanisms of osteocyte stimulation in osteoporosis
Verbruggen SW, Vaughan TJ and McNamara LM
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 62, 158-168.
10-05-2016
2015
- Modeling the biomechanics of fetal movements
Verbruggen SW, Loo JHW, Hayat TTA, Hajnal JV, Rutherford MA, Phillips ATM and Nowlan NC
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 15 (4), 995-1004.
03-11-2015 - Altered Mechanical Environment of Bone Cells in an Animal Model of Short- and Long-Term Osteoporosis
Verbruggen SW, Mc Garrigle MJ, Haugh MG, Voisin MC and McNamara LM
Biophysical Journal, Elsevier vol. 108 (7), 1587-1598.
01-04-2015
2014
- Bone cell mechanosensation of fluid flow stimulation: a fluid–structure interaction model characterising the role integrin attachments and primary cilia
Vaughan TJ, Mullen CA, Verbruggen SW and McNamara LM
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 14 (4), 703-718.
16-11-2014
2013
- Are all osteocytes equal? Multiscale modelling of cortical bone to characterise the mechanical stimulation of osteocytes
Vaughan TJ, Verbruggen SW and McNamara LM
International Journal For Numerical Methods in Biomedical Engineering, Wiley vol. 29 (12), 1361-1372.
29-07-2013 - Fluid flow in the osteocyte mechanical environment: a fluid–structure interaction approach
Verbruggen SW, Vaughan TJ and McNamara LM
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 13 (1), 85-97.
09-04-2013
2012
- Strain amplification in bone mechanobiology: a computational investigation of the in vivo mechanics of osteocytes
Verbruggen SW, Vaughan TJ and McNamara LM
Journal of The Royal Society Interface, The Royal Society vol. 9 (75), 2735-2744.
06-06-2012