Prof Julien Gautrot
On this page:
- Current Funded Research Projects
- Current PhD Studentship Projects
- Previous Funded Research Projects
- Previous PhD Studentship Projects
Current Funded Research Projects
Engineered Recombinant Strategies to Organogel Design for Food Product FormulationsFunding source: Motif Food Works Inc
Start: 01-09-2022 / End: 31-08-2026
A Biophysical Model of Gum Reintegration on enamelFunding source: GSK GlaxoSmithKline UK Ltd
Start: 01-10-2019 / End: 30-09-2023
Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue Engineering
Start: 01-09-2018 / End: 31-08-2023
ProLiCell will design the biochemical and mechanical properties of extracellular matrix (ECM) protein nanosheets that can sustain the formation of adhesion protein complexes and support cell proliferation and culture on materials with very weak bulk mechanical properties (liquids).
Current PhD Studentship Projects
MoBioCFunding source: Bit.Bio Ltd
Start: 01-09-2021 / End: 31-08-2024
Previous Funded Research Projects
Protein Nanosheet-Stabilised Emulsions for Next Generation BiomanufacturingFunding source: EU Commission - Horizon 2020
Start: 01-03-2021 / End: 31-08-2022
Translating Vasculature-on-a-Chips with a Nephrotoxicity ModelFunding source: NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research
Start: 01-07-2019 / End: 30-06-2021
2D composites with controlled nano-mechanisms
Start: 01-03-2018 / End: 28-02-2021
A long standing dogma in cell-based technologies is that bulk mechanical properties of solid substrates are essential to enable cell adhesion, proliferation and differentiation. However, the use of solid materials for cell culture constitutes an important hurdle for the scale up and automation of processes. We recently discovered that protein assembly at liquid-liquid interfaces results in mechanically strong protein layers sustaining cell spreading and directing fate decision. For long term culture, such interfaces lacked toughness and ruptured. This project will develop tough 2D nanocomposites assembled at oil-water interfaces and sustaining long term stem cell culture for applications in regenerative medicine.
Novel Cross-linking Strategy
Start: 01-10-2017 / End: 30-09-2020
This project focuses on the design of novel crosslinking strategies for silicone materials. These will enable the design of a new generation of silicone based composites with controlle mechanical properties and displaying conductive behaviour. The project will explore the use of these materials for 3D printing.
3D printing of hydroxyapatiteFunding source: GSK GlaxoSmithKline UK Ltd
Start: 03-02-2020 / End: 31-08-2020
Impact of Physiogel on tribological properties and structural integrity of the skinFunding source: GSK GlaxoSmithKline UK Ltd
Start: 01-09-2018 / End: 30-11-2019
Development of a microvascularised cerebral organoid-on-a-chipFunding source: EPSRC / MRC / BBSRC Technology Touching Life
Start: 04-02-2019 / End: 03-08-2019
This project proposes to combine a model of cerebral organoid (from the Lancaster laboratory) and a model of microvasculature-on-a-chip (from the Gautrot laboratory), to create the first microvascularised model of brain early development. We will study some of the factors that control the interaction of the two models and the formation of a mature interface between vasculatures and cerebral organoids. This model will be used to mimic neurodegenerative conditions and diseases, and for the development of therapeutic strategies.
A Biomimetic Gum Model for Biomechanical Testing
Start: 01-12-2017 / End: 30-11-2018
This project aims to study soft tissue mechanics and develop biomimetic model elastomers reproducing key biomechanical features of soft tissues.
Imaging Failure of Novel Denture AdhesivesFunding source: GSK GlaxoSmithKline UK Ltd
Start: 15-05-2018 / End: 31-10-2018
Proof of Concept 2017: Stem Cell Culture
Start: 01-09-2017 / End: 31-08-2018
This project aims to demonstrate the suitability of liquid-liquid interfaces and specifically oil-in-water emulsions for the long term culture of stem cells.
Development of a 3D Model of Dental IntegrationFunding source: GSK Consumer Healthcare Trading (UK) Ltd
Start: 01-02-2017 / End: 31-01-2018
Mimicking the Mechanical & Adhesive Properties of Oral Soft TissuesFunding source: GSK Consumer Healthcare Trading (UK) Ltd
Start: 20-06-2016 / End: 30-11-2017
Film Forming Polymer Actives in Oral Health ProductsFunding source: GSK CH (UK) Trading Ltd
Start: 01-07-2017 / End: 14-09-2017
Polymer Actives in Oral Health ProductsFunding source: GlaxoSmithKline R & D
Start: 31-05-2017 / End: 31-05-2017
International Exchange Scheme: BrazilFunding source: The Royal Society
Start: 01-03-2015 / End: 28-02-2017
Innovation Fund: Culture of Stem CellsFunding source: E.P.S.R.C.
Start: 01-08-2016 / End: 31-01-2017
Quantifying the Role of InterfacesFunding source: GlaxoSmithKline Consumer Healthcare
Start: 15-11-2015 / End: 30-04-2016
Design of Tough Compliant Graphene-Based CoatingsFunding source: E.P.S.R.C.
Start: 01-04-2015 / End: 31-03-2016
In collaboration with FormFormForm Ltd., the company behind the range of silicone-based resins called Sugru, the project will explore the use of graphene to generate heat and electrically conductive silicone based matrices, as well as the application of such composites as anti-corrosion coatings. Achieving high performance for such flexible silicone-based composites, thanks to the exceptional properties of graphene, could open up a wide range of applications for such silicone-based materials. Hence we will explore the use of this new technology to address some of the current challenges in the manufacturing industry.
UKIERI-DST Thematic PartnershipsFunding source: British Council
Start: 01-05-2013 / End: 31-01-2016
Quantifying and ImagingFunding source: SmithKlineBeecham Ltd
Start: 01-09-2015 / End: 13-10-2015
Quantifying & Imaging Failure at the Denture Adhesive InterfaceFunding source: GlaxoSmithKline Research & Development
Start: 11-01-2014 / End: 31-03-2015
Previous PhD Studentship Projects
Self Healing Elastomer Materials
Start: 01-05-2019 / End: 31-10-2022
Pumps used in slurry applications are typically lined with rubber liners to improve product lifetimes. This project aims to develop an intrinsic self-healing mechanism that can reduce the erosion rate of these liners.
CASE AwardFunding source: GlaxoSmithKline Research & Development
Start: 01-10-2015 / End: 30-09-2019
Industrial CASE Studentship Award 2014Funding source: GSK Service Unlimited / E.P.S.R.C.
Start: 01-10-2014 / End: 02-11-2018
Industrial CASE Studentship Award 2013Funding source: GSK Service Unlimited / E.P.S.R.C.
Start: 01-10-2013 / End: 30-09-2018
An Ovarian Cancer Model on a ChipFunding source: M.R.C.
Start: 01-09-2015 / End: 31-08-2018
StudentshipFunding source: FormFormForm Ltd
Start: 01-10-2013 / End: 30-09-2016