Dr Dongsheng Wu
PhD

Research Overview

Interests

Publications:

Okesola BO, Wu Y, Derkus B, Gani S, Wu D, Knani D, Smith DK, Adams DJ, Mata A (2019) Supramolecular self-sssembly to control structural and biological properties of multicomponent hydrogels. Chem Mater  https://doi.org/10.1021/acs.chemmater.9b01882

Walker RV, Keynton JL, Grimes DT, Esapa C, Wu D, Knight MM, Norris DP (2019) Exclusion of Polycystin-2 from the cilium promotes kidney cyst development in a model of autosomal dominant polycystic kidney disease. Nat Commun 10: 4072-4082

Gushchina S, Pryce G, Yip PK, Wu D, Pallier P, Giovannoni G, Baker D, Bo X. (2018) Increased expression of colony-stimulating factor-1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss. Glia 66: 2108-2125

Ge Z, Duan Z, Yang H, Zhang S, Zhang S, Wang L, Yang D, Sun X, Zhang Z, Su L, Zhu H, Zhou D, Liu B, Shi H, Yu J, Yang H, Chang Q, Zhang N, Wu D, Chen JDZ. (2018) Evid Based Complement Alternat Med Article ID 2086163

Wu D, Lee S, Luo J, Xia H, Gushchina S, Richardson PM, Yeh J, Krügel U, Franke H, Zhang Y, and Bo X. (2018) Intraneural injection of ATP stimulates regeneration of primary sensory axons in the spinal cord. J Neurosci 38:1351-65

Roig D, Cerutti C, Lopez-Ramirez MA, Wu D, Male DK, de Vries HE, Romero IA. (2017) MicroRNAs in Brain Endothelium and Inflammation. In book: The Blood-Brain Barrier in Inflammation, Publisher: Springer International Publishing Edition 1:153-173

Cerutti C, Soblechero-Martin P, Wu D, Lopez-Ramirez MA, de Vries HE, Sharrack B, Male DK and Romero IA. (2016) MicroRNA‑155 contributes to shear‑resistant leukocyte adhesion to human brain endothelium in vitro. Fluids Barriers CNS 13:8.

Wu D, Cerutti C, Lopez-Ramirez MA, Pryce G, King-Robson J, Simpson JE, van der Pol SM, Hirst MC, de Vries HE, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. (2015) Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation. J Cereb Blood Flow Metab 35:412-23.

Lopez-Ramirez MA, Wu D, Pryce G, Simpson JE, Reijerkerk A, King-Robson J, Kay O, de Vries HE, Hirst MC, Sharrack B, Baker D, Male DK, Michael GJ, Romero IA. (2014) MicroRNA-155 negatively affects blood-brain barrier function during neuroinflammation. FASEB J. 28:2551-65

Lopez-Ramirez MA, Male DK, Wang C, Sharrack B, Wu D and Romero IA. (2013) Cytokine-induced changes in the gene expression profile of a human cerebral microvascular endothelial cell-line, hCMEC/D3. Fluids Barriers CNS 10:27.

Luo J, Lee S, Wu D, Yeh J, Ellamushi H, Wheeler AP, Warnes G, Zhang Y and Bo X. (2013) P2X7 purinoceptors contribute to the death of Schwann cells transplanted into spinal cord. Cell Death and Dis 4:e829.

Zhang Y, Gao F, Wu D, Moshayedi P, Zhang X, Ellamushi H, Yeh J, Priestley JV, Bo X. (2013) Lentiviral mediated expression of a NGF-soluble Nogo receptor 1 fusion protein promotes axonal regeneration. Neurobiol Dis 58:270-80.

Bo X, Wu D, Yeh J, Zhang Y (2011) Gene therapy approaches for neuroprotection and axonal regeneration after spinal cord and spinal root injury. Curr Gene Ther11:101-15. (review)

Luo J, Bo X, Wu D, Yeh J, Richardson PM, Zhang Y (2011) Promoting survival, migration, and integration of transplanted Schwann cells by over-expressing polysialic acid. Glia 59:424-34.

Miao T, Wu D, Wheeler A, Wang P, Zhang Y, Bo X, Yeh J, Subang MC, Richardson PM (2011) Two cytokine signaling molecules co-operate to promote axonal transport and growth. Exp Neurol 228:165-72

Wu D, Yang P, Zhang X, Luo J, Haque ME, Yeh J, Richardson PM, Zhang Y, Bo X (2009) Targeting a dominant negative Rho kinase to neurons promotes axonal outgrowth and partial functional recovery after rat rubrospinal tract lesion. Mol Ther 17:2020-30.

Richardson PM, Miao T, Wu D, Zhang Y, Yeh J, Bo X (2009) Responses of the nerve cell body to axotomy. Neurosurg 65(4 Suppl):A74-9. (review)

Gushchina S, Leinster V, Wu D, Jasim A, Demestre M, Lopez de Heredia L, Michael GJ, Barker PA, Richardson PM, Magoulas C (2009) Observations on the function of nuclear factor kappa B (NF-kappaB) in the survival of adult primary sensory neurons after nerve injury. Mol Cell Neurosci 40:207-16.

Wu D, Huang W, Richardson PM, Priestley JV and Liu M (2008) TRPC4 in rat dorsal root ganglion neurons is increased after nerve injury and is necessary for neurite outgrowth. J Biol Chem 283:416-26.

Miao T*, Wu D*, Zhang Y, Bo X, Xiao F, Zhang X, Magoulas C, Subang MC, Wang P, Richardson PM (2008) SOCS3 suppresses AP-1 transcriptional activity in neuroblastoma cells through inhibition of c-Jun N-terminal kinase. Mol Cell Neurosci 37:367-75. (* equal contribution)

Zhang Y, Zhang X, Wu D, Verhaagen J, Richardson PM, Yeh J, Bo X (2007) Lentiviral mediated expression of polysialic acid in spinal cord and conditioning lesion promote regeneration of sensory axons into spinal cord. Mol Ther 15:1796-804.

Wu D, Zhang Y, Bo X, Huang W, Xiao F, Zhang X, Miao T, Magoulas C, Subang MC, Richardson PM (2007) Actions of neuropoietic cytokines and cyclic AMP in regenerative conditioning of rat primary sensory neurons. Exp Neurol 204:66-76.  

Miao T*, Wu D*, Zhang Y, Bo X, Subang MC, Wang P, Richardson PM (2006) Suppressor of cytokine signaling-3 suppresses the ability of activated signal transducer and activator of transcription-3 to stimulate neurite growth in rat primary sensory neurons. J Neurosci 26:9512-9. (* equal contribution)

Liu M, Huang W, Wu D, Priestley JV (2006) TRPV1, but not P2X, requires cholesterol for its function and membrane expression in rat nociceptors. Eur J Neurosci 24:1-6.

Wei M, Wu D, Yin J, Zhao G (2000) A case report of infant lateral ventricle choroid plexus papilloma. Chi J Neurosurg 3:1.

Wu D, Zhao G, Wei M (1999) The preliminary experimental and clinical observations on the active immunotherapy of tumor cell vaccine on malignant brain tumors. Chi J Neuroimmunol Neurol 6:134.

Wu D, Sun W, Wei M and Zhao G (1999) A case report of idiopathic herniation of the spinal cord. Chi J Neurosurg 15:17.

Wu D, Zhao G (1997) Glioma immunotherapy. Chi J Neuroimmunol Neurol 4: 51-5. (review)

Wu D, Zhao G, Wei M and Hang R (1995) Immune therapy of β/M tumor cell vaccine on murine glioblastoma G422. Chi J Cancer Biother 2:316.

Zhao G, Wu D, Chang P, Wei M, Wang Y, Sun S, Bai C, Xu X, Sun W, Yue Y, Yang W (1995). The effects of Newcastle disease virus vaccine on cellular immune function of patients with malignant brain tumor (analysis of 16 Cases). Chi J Cancer Biother 2:317.