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Queen Mary University of LondonQueen Mary University of London
Staff menu

Dr Stephen Thorpe
BA, BAI, PDipStat, PhD, FHEA

Dr Thorpe
Position: Researcher Co-Investigator
Supervisor: Prof David Lee
Tel: +44 (0)20 7882 3602
Location: 323, Engineering, Mile End
Expertise: I implement a range of engineering, biophysics and molecular biology techniques to probe cellular responses to biophysical signals. In addition to enhancing our understanding of cell mechanobiology, my research looks to leverage this understanding to develop cartilage and bone regenerative medicine strategies, and address the aberrant mechanobiology associated with one of the most lethal cancers, pancreatic ductal adenocarcinoma.
Research keywords: Mechanotransduction, Mechanobiology, Stem Cell, Tissue Mechanics, Cell Mechanics, Cytoskeleton, Chromatin, Nuclear Envelope,
Affiliations: Fellow of the Higher Education Academy

Brief Biography

Stephen graduated from Mechanical and Manufacturing Engineering at Trinity College Dublin in 2007. He remained at Trinity College to pursue a PhD investigating the role of mechanical stimuli in directing the chondrogenic differentiation of bone marrow-derived mesenchymal stem cells under the supervision of Dr Daniel Kelly. On graduating in 2012, Stephen moved to Queen Mary University of London as a post-doctoral research assistant with Dr Martin Knight and Prof David Lee on an EPSRC platform grant looking at multiscale mechanobiology for tissue engineering. In 2012, Stephen was awarded a Marie Curie Postdoctoral Fellowship to investigate the biophysical regulation of genome function and its role in mesenchymal stem cell differentiation in the lab of Prof David Lee. Stephen was subsequently awarded funding from the Biotechnology and Biological Sciences Research Council (BBSRC) to continue this research toward controlling stem cell fate via biophysical regulation of genome function.