Dr Stephen Thorpe
BA, BAI, PDipStat, PhD, FHEA
I am interested in the understanding of how mechanical stimuli impact cell function. In this regard, I have a particular interest in the role of the nucleus as a sensor of mechanical stimuli, and modulator of mechano-responsive signalling in stem cells. I implement a range of biological and engineering techniques to probe cellular processes in response to mechanical perturbation.
In addition to enhancing our basic understanding of stem cell mechanobiology, I apply many of these techniques toward improving cartilage tissue engineering and regenerative medicine strategies, and improving our understanding of cancer stem cell function.