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Dr Thomas Iskratsch
Dipl.-Ing. (Equiv. to MSc/MEng), PhD

 

Key Publications

  • Xanthis I and Iskratsch T (2019). "Lamin-A Mechano-Protects the Heart." Developmental Cell 
    17-06-2019
  • Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T and Palma M (2019). "Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control." Royal Society of Chemistry (Rsc)  Faraday Discussions 
    18-03-2019
  • Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). "Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions." Dev Cell  vol. 44, (3) 326-336.e3.
    05-02-2018
  • Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC and Iskratsch T (2015). "Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells." Integr Biol (Camb)  vol. 7, (10) 1272-1284.
    03-07-2015
  • Iskratsch T, Wolfenson H and Sheetz MP (2014). "Appreciating force and shape—the rise of mechanotransduction in cell biology." Nature Reviews. Molecular Cell Biology  vol. 15, (12) 825-833.
    01-12-2014

All Publications

    2021

    • Swiatlowska P and Iskratsch T (2021). "Announcing the call for the Special Issue on “Cardiovascular mechanobiology—a special issue to look at the state of the art and the newest insights into the role of mechanical forces in cardiovascular development, physiology, and disease”." Biophysical Reviews  vol. 13, (3) 307-308.
      01-06-2021
    • Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot JP, Duffau H, Dennis JW, Cornu D and Bakalara N (2021). "Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing." Journal of Experimental and Clinical Cancer Research  vol. 40, (1)
      24-04-2021

    2020

    2019

    • Di Cio S, Iskratsch T, Connelly JT and Gautrot JE (2019). "Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing." Elsevier  Biomaterials  vol. 232,
      16-12-2019
    • Xanthis I and Iskratsch T (2019). "Lamin-A Mechano-Protects the Heart." Developmental Cell 
      17-06-2019
    • Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T and Hodivala-Dilke K (2019). "Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation." American Association For Cancer Research  Cancer Research 
      12-06-2019
    • Sit B, Gutmann D and Iskratsch T (2019). "Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing." Journal of Muscle Research and Cell Motility  vol. 40, (2) 197-209.
      01-06-2019
    • Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T and Palma M (2019). "Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control." Royal Society of Chemistry (Rsc)  Faraday Discussions 
      18-03-2019

    2018

    • Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, ISKRATSCH T and Lappalainen P (2018). "Calponin-3 is critical for coordinated contractility of actin stress fibers." Nature Publishing Group  Scientific Reports 
      05-12-2018
    • Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). "Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions." Dev Cell  vol. 44, (3) 326-336.e3.
      05-02-2018

    2017

    2016

    • Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML and Sheetz MP (2016). "Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability." Immunol Cell Biol  vol. 94, (10) 981-993.
      30-06-2016
    • Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N, Tabdanov E, Lohner J, Gondarenko A, Chander AC, Roca-Cusachs P, O'Shaughnessy B, Hone J and Sheetz MP (2016). "α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions." Mol Biol Cell  vol. 27, (22) 3471-3479.
      27-04-2016

    2015

    • Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B, Hone J and Sheetz MP (2015). "Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices." Nat Cell Biol  vol. 18, (1) 33-42.
      30-11-2015
    • Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC and Iskratsch T (2015). "Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells." Integr Biol (Camb)  vol. 7, (10) 1272-1284.
      03-07-2015

    2014

    • Wolfenson H, Iskratsch T and Sheetz MP (2014). "Early events in cell spreading as a model for quantitative analysis of biomechanical events." Biophysical Journal  vol. 107, (11) 2508-2514.
      02-12-2014
    • Iskratsch T, Wolfenson H and Sheetz MP (2014). "Appreciating force and shape—the rise of mechanotransduction in cell biology." Nature Reviews. Molecular Cell Biology  vol. 15, (12) 825-833.
      01-12-2014
    • Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG and Ehler E (2014). "The formin FHOD1 in cardiomyocytes." Anat Rec (Hoboken)  vol. 297, (9) 1560-1570.
      14-08-2014
    • Zhang X, Moore SW, Iskratsch T and Sheetz MP (2014). "N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading." Journal of Cell Science  vol. 127, (7) 1394-1405.
      01-01-2014

    2013

    • Iskratsch T, Yu CH, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E and Sheetz M (2013). "FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration." Developmental Cell  vol. 27, (5) 545-559.
      09-12-2013
    • Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I and Ehler E (2013). "Two distinct phosphorylation events govern the function of muscle FHOD3." Cellular and Molecular Life Sciences  vol. 70, (5) 893-908.
      01-03-2013
    • Lynch CD, Lazar AM, Iskratsch T, Zhang X and Sheetz MP (2013). "Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions." Molecular Biology of The Cell  vol. 24, (1) 21-30.
      01-01-2013

    2012

    • Roca-Cusachs P, Iskratsch T and Sheetz MP (2012). "Finding the weakest link-exploring integrin-mediated mechanical molecular pathways." Journal of Cell Science  vol. 125, (13) 3025-3038.
      01-07-2012
    • Dwyer J, Iskratsch T and Ehler E (2012). "Actin in striated muscle: Recent insights into assembly and maintenance." Biophysical Reviews  vol. 4, (1) 17-25.
      01-03-2012

    2011

    2010

    • Iskratsch T, Lange S, Dwyer J, Kho AL, Dos Remedios C and Ehler E (2010). "Formin follows function: A muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance." Journal of Cell Biology  vol. 191, (6) 1159-1172.
      13-12-2010

    2009

    • Herbst R, Iskratsch T, Unger E and Bittner RE (2009). "Aberrant development of neuromuscular junctions in glycosylation-defective Largemyd mice." Neuromuscular Disorders  vol. 19, (5) 366-378.
      01-05-2009
    • Gutternigg M, Rendi¿ D, Voglauer R, Iskratsch T and Wilson IBH (2009). "Mammalian cells contain a second nucleocytoplasmic Hexosaminidase." Biochemical Journal  vol. 419, (1) 83-90.
      01-04-2009
    • Iskratsch T, Braun A, Paschinger K and Wilson IBH (2009). "Specificity analysis of lectins and antibodies using remodeled glycoproteins." Analytical Biochemistry  vol. 386, (2) 133-146.
      15-03-2009