Dr Thomas Iskratsch
Dipl.-Ing. (Equiv. to MSc/MEng), PhD

 
 
 

Key Publications

  • Xanthis I and Iskratsch T (2019-06-17). "Lamin-A Mechano-Protects the Heart." Developmental Cell 
    17-06-2019
  • Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T and Palma M (2019-03-18). "Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control." Royal Society of Chemistry (Rsc)  Faraday Discussions 
    18-03-2019
  • Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018-02-05). "Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions." Dev Cell  vol. 44, (3) 326-336.e3.
    05-02-2018
  • Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC and Iskratsch T (2015-07-03). "Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells." Integr Biol (Camb)  vol. 7, (10) 1272-1284.
    03-07-2015
  • Iskratsch T, Wolfenson H and Sheetz MP (2014-12-01). "Appreciating force and shape—the rise of mechanotransduction in cell biology." Nature Reviews. Molecular Cell Biology  vol. 15, (12) 825-833.
    01-12-2014

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All Publications

    2020

    • Ward M and Iskratsch T (2020). "Mix and (mis-)match – The mechanosensing machinery in the changing environment of the developing, healthy adult and diseased heart." Biochimica Et Biophysica Acta - Molecular Cell Research  vol. 1867, (3)
      01-03-2020

    2019

    • Di Cio S, Iskratsch T, Connelly JT and Gautrot JE (2019). "Contractile myosin rings and cofilin-mediated actin disassembly orchestrate ECM nanotopography sensing." Elsevier  Biomaterials  vol. 232,
      16-12-2019
    • Xanthis I and Iskratsch T (2019). "Lamin-A Mechano-Protects the Heart." Developmental Cell 
      17-06-2019
    • Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T and Hodivala-Dilke K (2019). "Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation." American Association For Cancer Research  Cancer Research 
      12-06-2019
    • Sit B, Gutmann D and Iskratsch T (2019). "Costameres, dense plaques and podosomes: the cell matrix adhesions in cardiovascular mechanosensing." Journal of Muscle Research and Cell Motility  vol. 40, (2) 197-209.
      01-06-2019
    • Hawkes W, Huang D, Reynolds P, Hammond L, Ward M, Gadegaard N, Marshall JF, Iskratch T and Palma M (2019). "Probing the nanoscale organisation and multivalency of cell surface receptors: DNA origami nanoarrays for cellular studies with single-molecule control." Royal Society of Chemistry (Rsc)  Faraday Discussions 
      18-03-2019

    2018

    • Ciuba K, Hawkes W, Tojkander S, Kogan K, Engel U, ISKRATSCH T and Lappalainen P (2018). "Calponin-3 is critical for coordinated contractility of actin stress fibers." Nature Publishing Group  Scientific Reports 
      05-12-2018
    • Pandey P, Hawkes W, Hu J, Megone WV, Gautrot J, Anilkumar N, Zhang M, Hirvonen L, Cox S, Ehler E, Hone J, Sheetz M and Iskratsch T (2018). "Cardiomyocytes Sense Matrix Rigidity through a Combination of Muscle and Non-muscle Myosin Contractions." Dev Cell  vol. 44, (3) 326-336.e3.
      05-02-2018

    2017

    2016

    • Santos LC, Blair DA, Kumari S, Cammer M, Iskratsch T, Herbin O, Alexandropoulos K, Dustin ML and Sheetz MP (2016). "Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability." Immunol Cell Biol  vol. 94, (10) 981-993.
      30-06-2016
    • Meacci G, Wolfenson H, Liu S, Stachowiak MR, Iskratsch T, Mathur A, Ghassemi S, Gauthier N, Tabdanov E, Lohner J, Gondarenko A, Chander AC, Roca-Cusachs P, O'Shaughnessy B, Hone J and Sheetz MP (2016). "α-Actinin links extracellular matrix rigidity-sensing contractile units with periodic cell-edge retractions." Mol Biol Cell  vol. 27, (22) 3471-3479.
      27-04-2016

    2015

    • Wolfenson H, Meacci G, Liu S, Stachowiak MR, Iskratsch T, Ghassemi S, Roca-Cusachs P, O'Shaughnessy B, Hone J and Sheetz MP (2015). "Tropomyosin controls sarcomere-like contractions for rigidity sensing and suppressing growth on soft matrices." Nat Cell Biol  vol. 18, (1) 33-42.
      30-11-2015
    • Tabdanov E, Gondarenko S, Kumari S, Liapis A, Dustin ML, Sheetz MP, Kam LC and Iskratsch T (2015). "Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells." Integr Biol (Camb)  vol. 7, (10) 1272-1284.
      03-07-2015

    2014

    • Wolfenson H, Iskratsch T and Sheetz MP (2014). "Early events in cell spreading as a model for quantitative analysis of biomechanical events." Biophysical Journal  vol. 107, (11) 2508-2514.
      02-12-2014
    • Iskratsch T, Wolfenson H and Sheetz MP (2014). "Appreciating force and shape—the rise of mechanotransduction in cell biology." Nature Reviews. Molecular Cell Biology  vol. 15, (12) 825-833.
      01-12-2014
    • Dwyer J, Pluess M, Iskratsch T, Dos Remedios CG and Ehler E (2014). "The formin FHOD1 in cardiomyocytes." Anat Rec (Hoboken)  vol. 297, (9) 1560-1570.
      14-08-2014
    • Zhang X, Moore SW, Iskratsch T and Sheetz MP (2014). "N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading." Journal of Cell Science  vol. 127, (7) 1394-1405.
      01-01-2014

    2013

    • Iskratsch T, Yu CH, Mathur A, Liu S, Stévenin V, Dwyer J, Hone J, Ehler E and Sheetz M (2013). "FHOD1 is needed for directed forces and adhesion maturation during cell spreading and migration." Developmental Cell  vol. 27, (5) 545-559.
      09-12-2013
    • Iskratsch T, Reijntjes S, Dwyer J, Toselli P, Dégano IR, Dominguez I and Ehler E (2013). "Two distinct phosphorylation events govern the function of muscle FHOD3." Cellular and Molecular Life Sciences  vol. 70, (5) 893-908.
      01-03-2013
    • Lynch CD, Lazar AM, Iskratsch T, Zhang X and Sheetz MP (2013). "Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions." Molecular Biology of The Cell  vol. 24, (1) 21-30.
      01-01-2013

    2012

    • Dwyer J, Iskratsch T and Ehler E (2012). "Actin in striated muscle: Recent insights into assembly and maintenance." Biophysical Reviews  vol. 4, (1) 17-25.
      01-12-2012
    • Roca-Cusachs P, Iskratsch T and Sheetz MP (2012). "Finding the weakest link-exploring integrin-mediated mechanical molecular pathways." Journal of Cell Science  vol. 125, (13) 3025-3038.
      01-07-2012

    2011

    2010

    • Iskratsch T, Lange S, Dwyer J, Kho AL, Dos Remedios C and Ehler E (2010). "Formin follows function: A muscle-specific isoform of FHOD3 is regulated by CK2 phosphorylation and promotes myofibril maintenance." Journal of Cell Biology  vol. 191, (6) 1159-1172.
      13-12-2010

    2009

    • Herbst R, Iskratsch T, Unger E and Bittner RE (2009). "Aberrant development of neuromuscular junctions in glycosylation-defective Largemyd mice." Neuromuscular Disorders  vol. 19, (5) 366-378.
      01-05-2009
    • Gutternigg M, Rendi¿ D, Voglauer R, Iskratsch T and Wilson IBH (2009). "Mammalian cells contain a second nucleocytoplasmic Hexosaminidase." Biochemical Journal  vol. 419, (1) 83-90.
      01-04-2009
    • Iskratsch T, Braun A, Paschinger K and Wilson IBH (2009). "Specificity analysis of lectins and antibodies using remodeled glycoproteins." Analytical Biochemistry  vol. 386, (2) 133-146.
      15-03-2009