Dr Oliver Pearce
BSc PhD
All Publications
2021
- Malacrida B, Nichols S, Maniati E, Jones R, Delanie-Smith R, Roozitalab R, Tyler EJ, Thomas M, Boot G, Mackerodt J, Lockley M, Knight MM, Balkwill FR and Pearce OMT (2021). "A human multi-cellular model shows how platelets drive production of diseased extracellular matrix and tissue invasion." Iscience vol. 24, (6)
25-06-2021 - Delaine-Smith RM, Maniati E, Malacrida B, Nichols S, Roozitalab R, Jones RR, Lecker LSM, Pearce OMT, Knight MM and Balkwill FR (2021). "Modelling TGFβR and Hh pathway regulation of prognostic matrisome molecules in ovarian cancer." Iscience vol. 24, (6)
25-06-2021 - Verbruggen SW, Thompson CL, Duffy MP, Lunetto S, Nolan J, Pearce OMT, Jacobs CR and Knight MM (2021). "Mechanical stimulation modulates osteocyte regulation of cancer cell phenotype." Cancers vol. 13, (12)
02-06-2021 - Reuten R, Zendehroud S, Nicolau M, Fleischhauer L, Laitala A, Kiderlen S, Nikodemus D, Wullkopf L, Nielsen SR, McNeilly S, Prein C, Rafaeva M, Schoof EM, Furtwängler B, Porse BT, Kim H, Won KJ, Sudhop S, Zornhagen KW, Suhr F, Maniati E, Pearce OMT, Koch M, Oddershede LB, Van Agtmael T, Madsen CD, Mayorca-Guiliani AE, Bloch W, Netz RR and Clausen-Schaumann H (2021). "Basement membrane stiffness determines metastases formation." Nature Materials vol. 20, (6) 892-903.
01-06-2021
2020
- Pearce OMT and Läubli H (2020). "A sweet approach to heat up cancer response to immunotherapy." Cancer Discovery vol. 10, (12) 1789-1790.
01-12-2020 - Zaghdoudi S, Decaup E, Belhabib I, Samain R, Cassant-Sourdy S, Rochotte J, Brunel A, Schlaepfer D, Cros J, Neuzillet C, Strehaiano M, Alard A, Tomasini R, Rajeeve V, Perraud A, Mathonnet M, Pearce OMT, Martineau Y, Pyronnet S, Bousquet C and Jean C (2020). "FAK activity in cancer-associated fibroblasts is a prognostic marker and a druggable key metastatic player in pancreatic cancer." Embo Molecular Medicine vol. 12, (11)
06-11-2020 - Wight TN, Kang I, Evanko SP, Harten IA, Chang MY, Pearce OMT, Allen CE and Frevert CW (2020). "Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation." Frontiers Media Frontiers in Immunology vol. 11,
24-03-2020 - Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C, Delaine-Smith RM, Pearce OMT, Hirani P, Joy JD, Szabova L, Perets R, Sansom OJ, Drapkin R, Bailey P and Balkwill FR (2020). "Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment." Cell Reports vol. 30, (2) 525-540.e7.
14-01-2020
2018
- Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR and Hynes RO (2018). "Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics." Journal of Proteome Research vol. 16, (8) 3083-3091.
01-12-2018 - Pearce OMT and Läubli H (2018). "Cancer Immunotherapy." Glycobiology vol. 28, (9) 638-639.
01-09-2018 - Pearce OM (2018). "Cancer glycan epitopes: biosynthesis, structure, and function." Glycobiology
13-03-2018
2017
- Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR (2017). "Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers." Cancer Discov
01-12-2017 - Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG and Varki A (2017). "N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils." Proc Natl Acad Sci U S A vol. 114, (39) E8155-E8164.
26-09-2017
2016
- Montfort A, Pearce OMT, Maniati E, Vincent B, Bixby LM, Bo hm S, Dowe T, Wilkes EH, Chakravarty P, Thompson R, Topping J, Cutillas PR, Lockley M, Serody JS, Capasso M and Balkwill FR (2016). "A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases." American Association For Cancer Research Clinical Cancer Research
27-06-2016 - BALKWILL F, Anne Montfort and Oliver Pearce (2016). "Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma." American Association For Cancer Research Clinical Cancer Research
01-04-2016
2015
- Pearce OMT and Läubli H (2015). "Sialic acids in cancer biology and immunity." Glycobiology vol. 26, (2) 111-128.
04-10-2015 - Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). "Interleukin-6 stimulates defective angiogenesis." Cancer Research vol. 75, (15) 3098-3107.
01-08-2015 - Gopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Leinster A, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). "Abstract 4162: Interleukin–6 stimulates defective angiogenesis."
01-08-2015 - Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OMT, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K and Sato C (2015). "Rapid trimming of cell surface polysialic acid (PolySia) by exovesicular sialidase triggers release of preexisting surface neurotrophin." Journal of Biological Chemistry vol. 290, (21) 13202-13214.
22-05-2015 - Schwarz F, Pearce OMT, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X, Garcia-Bingman A, Secrest P, Romanoski CE, Heyser C, Glass CK, Hazen SL, Varki N, Varki A and Gagneux P (2015). "Siglec receptors impact mammalian lifespan by modulating oxidative stress." Elife vol. 2015, (4)
07-04-2015 - Pearce OMT, Samraj AN, Läubli H, Varki NM and Varki A (2015). "Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens." Proceedings of The National Academy of Sciences of The United States of America vol. 112, (12)
24-03-2015 - Samraj AN, Pearce OMT, Läubli H, Crittenden AN, Bergfeld AK, Band K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM, Varki A and Kornfeld SA (2015). "A red meat-derived glycan promotes inflammation and cancer progression." Proceedings of The National Academy of Sciences of The United States of America vol. 112, (2) 542-547.
13-01-2015
2014
- Läubli H, Pearce OMT, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki NM, Bui JD and Varki A (2014). "Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer." Proceedings of The National Academy of Sciences of The United States of America vol. 111, (39) 14211-14216.
30-09-2014 - Pearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Varki NM, Crocker PR, Bui JD and Varki A (2014). "Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies." Proceedings of The National Academy of Sciences of The United States of America vol. 111, (16) 5998-6003.
22-04-2014 - Pearce OMT, Läubli H, Bui J and Varki A (2014). "Hormesis in cancer immunology: Does the quantity of an immune reactant matter?" Oncoimmunology vol. 3, (6)
01-01-2014
2013
- Buchlis G, Odorizzi P, Soto PC, Pierce OMT, Hui DJ, Jordan MS, Varki A, Wherry EJ and High KA (2013). "Enhanced T cell function in a mouse model of human glycosylation." Journal of Immunology vol. 191, (1) 228-237.
01-07-2013
2012
- Bergfeld AK, Pearce OMT, Diaz SL, Pham T and Varki A (2012). "Metabolism of vertebrate amino sugars with N-glycolyl groups: Elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid." Journal of Biological Chemistry vol. 287, (34) 28865-28881.
17-08-2012 - Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woodss R and Varki A (2012). "Metabolism of vertebrate amino sugars with N-glycolyl groups: Resistance of α2-8-linked N-glycolylneuraminic acid to enzymatic cleavage." Journal of Biological Chemistry vol. 287, (34) 28917-28931.
17-08-2012 - Bergfeld AK, Pearce OMT, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD and Varki A (2012). "Metabolism of vertebrate amino sugars with N-glycolyl groups: Incorporation of N-glycolylhexosamines into mammalian glycans by feeding N- glycolylgalactosamine." Journal of Biological Chemistry vol. 287, (34) 28898-28916.
17-08-2012
2010
- Pearce OMT and Varki A (2010). "Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose." Carbohydrate Research vol. 345, (9) 1225-1229.
16-06-2010
2005
- Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A and Davis BG (2005). "Glycoviruses: Chemical glycosylation retargets adenoviral gene transfer." Angewandte Chemie - International Edition vol. 44, (7) 1057-1061.
04-02-2005