Dr Oliver Pearce

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All Publications


    • Wight TN, Kang I, Evanko SP, Harten IA, Chang MY, Pearce OMT, Allen CE and Frevert CW (2020). "Versican—A Critical Extracellular Matrix Regulator of Immunity and Inflammation." Frontiers in Immunology  vol. 11,
    • Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C, Delaine-Smith RM, Pearce OMT, Hirani P, Joy JD, Szabova L, Perets R, Sansom OJ, Drapkin R, Bailey P and Balkwill FR (2020). "Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment." Cell Reports  vol. 30, (2) 525-540.e7.



    • Pearce OMT, Delaine-Smith R, Maniati E, Nichols S, Wang J, Böhm S, Rajeeve V, Ullah D, Chakravarty P, Jones RR, Montfort A, Dowe T, Gribben J, Jones JL, Kocher HM, Serody JS, Vincent BG, Connelly J, Brenton JD, Chelala C, Cutillas PR, Lockley M, Bessant C, Knight M and Balkwill FR (2017). "Deconstruction of a metastatic tumor microenvironment reveals a common matrix response in human cancers." Cancer Discov 
    • Bergfeld AK, Lawrence R, Diaz SL, Pearce OMT, Ghaderi D, Gagneux P, Leakey MG and Varki A (2017). "N-glycolyl groups of nonhuman chondroitin sulfates survive in ancient fossils." Proc Natl Acad Sci U S A  vol. 114, (39) E8155-E8164.
    • Naba A, Pearce OMT, Del Rosario A, Ma D, Ding H, Rajeeve V, Cutillas PR, Balkwill FR and Hynes RO (2017). "Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics." Journal of Proteome Research  vol. 16, (8) 3083-3091.


    • Montfort A, Pearce OMT, Maniati E, Vincent B, Bixby LM, Bo hm S, Dowe T, Wilkes EH, Chakravarty P, Thompson R, Topping J, Cutillas PR, Lockley M, Serody JS, Capasso M and Balkwill FR (2016). "A strong B cell response is part of the immune landscape in human high-grade serous ovarian metastases." American Association For Cancer Research  Clinical Cancer Research 
    • BALKWILL F, Anne Montfort and Oliver Pearce (2016). "Neoadjuvant chemotherapy modulates the immune microenvironment in metastases of tubo-ovarian high-grade serous carcinoma." American Association For Cancer Research  Clinical Cancer Research 
    • Pearce OMT and Läubli H (2016). "Sialic acids in cancer biology and immunity." Glycobiology  vol. 26, (2) 111-128.


    • Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). "Interleukin-6 stimulates defective angiogenesis." Cancer Research  vol. 75, (15) 3098-3107.
    • Sumida M, Hane M, Yabe U, Shimoda Y, Pearce OMT, Kiso M, Miyagi T, Sawada M, Varki A, Kitajima K and Sato C (2015). "Rapid Trimming of Cell Surface Polysialic Acid (PolySia) by Exovesicular Sialidase Triggers Release of Preexisting Surface Neurotrophin." J Biol Chem  vol. 290, (21) 13202-13214.
    • Schwarz F, Pearce OMT, Wang X, Samraj AN, Läubli H, Garcia JO, Lin H, Fu X, Garcia-Bingman A, Secrest P, Romanoski CE, Heyser C, Glass CK, Hazen SL, Varki N, Varki A and Gagneux P (2015). "Siglec receptors impact mammalian lifespan by modulating oxidative stress." Elife  vol. 4,
    • Pearce OMT, Samraj AN, Läubli H, Varki NM and Varki A (2015). "Reply to Mackenzie: A comparison of Neu5Gc and α-gal xenoantigens." Proc Natl Acad Sci U S A  vol. 112, (12)
    • Samraj AN, Pearce OMT, Läubli H, Crittenden AN, Bergfeld AK, Banda K, Gregg CJ, Bingman AE, Secrest P, Diaz SL, Varki NM and Varki A (2015). "A red meat-derived glycan promotes inflammation and cancer progression." Proc Natl Acad Sci U S A  vol. 112, (2) 542-547.


    • Läubli H, Pearce OMT, Schwarz F, Siddiqui SS, Deng L, Stanczak MA, Verhagen A, Secrest P, Lusk C, Schwartz AG, Varki NM, Bui JD and Varki A (2014). "Engagement of myelomonocytic Siglecs by tumor-associated ligands modulates the innate immune response to cancer." Proc Natl Acad Sci U S A  vol. 111, (39) 14211-14216.
    • Pearce OMT, Läubli H, Verhagen A, Secrest P, Zhang J, Varki NM, Crocker PR, Bui JD and Varki A (2014). "Inverse hormesis of cancer growth mediated by narrow ranges of tumor-directed antibodies." Proc Natl Acad Sci U S A  vol. 111, (16) 5998-6003.
    • Pearce OM, Läubli H, Bui J and Varki A (2014). "Hormesis in cancer immunology: Does the quantity of an immune reactant matter?" Oncoimmunology  vol. 3,


    • Buchlis G, Odorizzi P, Soto PC, Pearce OMT, Hui DJ, Jordan MS, Varki A, Wherry EJ and High KA (2013). "Enhanced T cell function in a mouse model of human glycosylation." J Immunol  vol. 191, (1) 228-237.


    • Bergfeld AK, Pearce OMT, Diaz SL, Pham T and Varki A (2012). "Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid." J Biol Chem  vol. 287, (34) 28865-28881.
    • Davies LRL, Pearce OMT, Tessier MB, Assar S, Smutova V, Pajunen M, Sumida M, Sato C, Kitajima K, Finne J, Gagneux P, Pshezhetsky A, Woods R and Varki A (2012). "Metabolism of vertebrate amino sugars with N-glycolyl groups: resistance of α2-8-linked N-glycolylneuraminic acid to enzymatic cleavage." J Biol Chem  vol. 287, (34) 28917-28931.
    • Bergfeld AK, Pearce OMT, Diaz SL, Lawrence R, Vocadlo DJ, Choudhury B, Esko JD and Varki A (2012). "Metabolism of vertebrate amino sugars with N-glycolyl groups: incorporation of N-glycolylhexosamines into mammalian glycans by feeding N-glycolylgalactosamine." J Biol Chem  vol. 287, (34) 28898-28916.


    • Pearce OMT and Varki A (2010). "Chemo-enzymatic synthesis of the carbohydrate antigen N-glycolylneuraminic acid from glucose." Carbohydr Res  vol. 345, (9) 1225-1229.


    • Pearce OMT, Fisher KD, Humphries J, Seymour LW, Smith A and Davis BG (2005). "Glycoviruses: chemical glycosylation retargets adenoviral gene transfer." Angew Chem Int Ed Engl  vol. 44, (7) 1057-1061.