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Dr Hannah Heywood


Research Funding

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Current Funded Research Projects

Incorporating the circadian clock into Organ-on-a-chip (OOAC) devices

Funding source: MRC/HEIF
Start: 01-04-2020  /  End: 31-01-2022
Amount: £102,000

Studies to support the development of more physiologically relevant in vitro model systems which incorporate the circadian clock

Previous Funded Research Projects

Does the biological clock within cartilage align to diurnal patterns in activity?

Funding source: EPSRC Engineering and Physical Sciences Research Council
Start: 01-10-2019  /  End: 31-03-2020

Augmenting sirtuin activity to drive cartilage regeneration and treat osteoarthritis.

Funding source: Dunhill Medical Trust
Start: 01-11-2014  /  End: 31-12-2016

Osteoarthritis (OA) is a highly prevalent disease involving degeneration of articular cartilage and chronic inflammation of the joints, with Worldwide estimates that 9.6% of men and 18.0% of women aged >60 years have symptomatic OA. Prevalence increases with age, such that OA is expected to be the fourth leading cause of disability by the year 2020 (WHO report, 2003). Thus factors that slow the onset or progression of this disease will significantly benefit the well-being of older people.

Does Warburg energy metabolism contribute to the phenotypic stability of monolayer expanded chondrocytes?

Funding source: MRC
Start: 01-08-2010  /  End: 30-10-2010

Elucidating the contribution of bioenergetic phenotype to the preservation of the differentiated chondrocyte phenotype in vitro.

The modulation of metabolic phenotype in chondrocytes during monolayer expansion in relation to synthetic phenotypic stability, oxidative stress and proliferative senescence.

Funding source: Wellcome Trust
Start: 01-02-2007  /  End: 31-08-2010

Elucidating the role of the chondrocyte bioenergetic phenotype in the preservation of a differentiated synthetic phenotype and senescence in vitro.