Dr David Gould

 

Key Publications

  • Quantitative imaging of cartilage and bone for functional assessment of gene therapy approaches in experimental arthritis
    Stok KS, Noel D, Apparailly F, Gould D, Chernajovsky Y, Jorgensen C and Muller R
    J Tissue Eng Regen M vol. 4 (5), 387-394.  
    01-07-2010
  • Human single-chain variable fragment that specifically targets arthritic cartilage.
    Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil N, Marrelli A, Gould D, Subang C, Al-Kashi A, De Bari C, Winyard P, Chernajovsky Y and Nissim A
    Arthritis Rheum vol. 62 (4), 1007-1016.  
    01-04-2010
  • Dual luciferase labelling for non-invasive bioluminescence imaging of mesenchymal stromal cell chondrogenic differentiation in demineralized bone matrix scaffolds
    Vilalta M, Jorgensen C, Degano IR, Chernajovsky Y, Gould D, Noel D, Andrades JA, Becerra J, Rubio N and Blanco J
    Biomaterials vol. 30 (28), 4986-4995.  
    01-10-2009
  • Biodistribution, Long-term Survival, and Safety of Human Adipose Tissue-derived Mesenchymal Stem Cells Transplanted in Nude Mice by High Sensitivity Non-invasive Bioluminescence Imaging
    Vilalta M, Degano IR, Bago J, Gould D, Santos M, Garcia-Arranz M, Ayats R, Fuster C, Chernajovsky Y, Garcia-Olmo D, Rubio N and Blanco J
    Stem Cells Dev vol. 17 (5), 993-1003.  
    01-10-2008
  • Repopulation of B-lymphocytes with restricted gene expression using haematopoietic stem cells engineered with lentiviral vectors.
    Taher TE, Tulone C, Fatah R, D'Acquisto F, Gould DJ and Mageed RA
    Gene Ther vol. 15 (13), 998-1006.  
    01-07-2008

All Publications

Page 1 of 2

2025

  • Injectable biodegradable microchamber array films for long-term delivery of glucocorticoids
    Zhang J, Read JE, Mittal G, Poston RN, Reilly J, Howling G, Golland B, Sukhorukov GB and Gould D
    Journal of Controlled Release, Elsevier vol. 381 
    27-02-2025

2024

  • OR069 A NOVEL COATING ONTO LEONARD BUTTONS; SURGICAL SITE INFECTION PREVENTION IN MANDIBULAR FRACTURES
    Alostath H, Chatzopoulou D, Holmes S, Stephen A, Gould D, Sukhorukov G and Cattell M
    International Journal of Oral and Maxillofacial Surgery, Elsevier vol. 52 
    01-01-2024

2023

  • Synthesis of Novel Antimicrobial CHX-CaCl2 Coatings on Maxillofacial Fixatures for Infection Prevention
    Cattell M, Chatzopoulou D, Hawraa A, Gould D, Sukhorukov G and Holmes S
    , Editors: Hu L. International Journal of Molecular Sciences, Mdpi vol. 24 (12), 1-12.  
    06-06-2023
  • Drug-Eluting Sandwich Hydrogel Lenses Based on Microchamber Film Drug Encapsulation
    Kudryavtseva V, Otero M, Zhang J, Bukatin A, Gould D and Sukhorukov GB
    Acs Nanoscience Au, American Chemical Society (Acs) vol. 3 (3), 256-265.  
    05-04-2023

2022

  • Metabolic requirements of Th17 cells and of B cells: Regulation and defects in health and in inflammatory diseases
    Bystrom J, Taher TE, Henson SM, Gould DJ and Mageed RA
    Frontiers in Immunology, Frontiers vol. 13 
    14-10-2022
  • Electrical characterization of micron sized chambers used as a depot for drug delivery
    Khan AN, Ermakov A, Saunders T, Giddens H, Gould D, Sukhorukov G and Hao Y
    IEEE Sensors Journal, Institute of Electrical and Electronics Engineers 
    03-08-2022
  • Printed asymmetric microcapsules: Facile loading and multiple stimuli-responsiveness
    Kudryavtseva V, Bukatin A, Vyacheslavova E, Gould D and Sukhorukov GB
    Biomaterials Advances, Elsevier vol. 136 
    17-03-2022

2021

  • Abstract 916: A novel LAP-IL2 fusion protein elicits efficacy as single agent in syngeneic renal and melanoma mouse models
    Riveiro ME, Frapolli R, Taraboletti GTG, Rezai K, Meroni M, Russo M, Borsotti P, Schultz C, Gould D and Chernajovsky Y
    Cancer Research, American Association For Cancer Research (Aacr) vol. 81 (13_Supplement), 916-916.  
    01-07-2021
  • Micro-sized pelmeni - A universal microencapsulation approach overview
    Kudryavtseva V, Boi S, Read J, Gould D, Szewczyk PK, Stachewicz U, Kiryukhin MV, Pastorino L and Sukhorukov GB
    Materials & Design, Elsevier vol. 202 
    01-04-2021
  • Biodegradable Defined Shaped Printed Polymer Microcapsules for Drug Delivery
    Kudryavtseva V, Boi S, Read J, Guillemet R, Zhang J, Udalov A, Shesterikov E, Tverdokhlebov S, Pastorino L, Gould DJ and Sukhorukov GB
    Acs Applied Materials & Interfaces, American Chemical Society (Acs) vol. 13 (2), 2371-2381.  
    06-01-2021

2020

  • Polylactic Acid-Based Patterned Matrixes for Site-Specific Delivery of Neuropeptides On-Demand: Functional NGF Effects on Human Neuronal Cells
    Sindeeva OA, Kopach O, Kurochkin MA, Sapelkin A, Gould DJ, Rusakov DA and Sukhorukov GB
    Frontiers in Bioengineering and Biotechnology, Frontiers vol. 8 
    12-06-2020
  • Toward gene therapy in rheumatoid arthritis
    Young E, Gould D and Hart S
    Expert Review of Precision Medicine and Drug Development, Taylor && Francis, 1-11.  
    10-03-2020
  • Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production
    Read JE, Luo D, Chowdhury TT, Flower RJ, Poston RN, Sukhorukov GB and Gould DJ
    Nanoscale, Royal Society of Chemistry (Rsc) vol. 12 (14), 7735-7748.  
    01-01-2020

2018

  • Magnetically targetable microcapsules display subtle changes in permeability and drug release in response to a biologically compatible low frequency alternating magnetic field
    Luo D, Poston RN, Gould DJ and Sukhorukov GB
    Materials Science and Engineering C, Elsevier vol. 94, 647-655.  
    06-10-2018
  • Ceria Nanoparticles-Decorated Microcapsules as a Smart Drug Delivery/Protective System: Protection of Encapsulated P. pyralis Luciferase.
    Popov AL, Popova N, Gould DJ, Shcherbakov AB, Sukhorukov GB and Ivanov VK
    Acs Appl Mater Interfaces vol. 10 (17), 14367-14377.  
    10-04-2018
  • In-situ NIR-laser mediated bioactive substance delivery to single cell for EGFP expression based on biocompatible microchamber-arrays.
    Gai M, Kurochkin MA, Li D, Khlebtsov BN, Dong L, Tarakina N, Poston R, Gould DJ, Frueh J and Sukhorukov GB
    J Control Release vol. 276, 84-92.  
    16-03-2018

2017

2016

  • Electrospun poly (lactic acid) fibers containing novel chlorhexidine particles with sustained antibacterial activity.
    CATTELL MJ, Sukhorukov G, Gould DJ, shahid S, Zhang X and Luo DONG
    , Editors: Jun Wang . Biomaterials Science, Royal Society of Chemistry 
    25-11-2016
  • Photodynamic therapy platform based on localized delivery of photosensitizer by vaterite submicron particles.
    Svenskaya YI, Pavlov AM, Gorin DA, Gould DJ, Parakhonskiy BV and Sukhorukov GB
    Colloids Surf B Biointerfaces vol. 146, 171-179.  
    01-10-2016
  • Assembly PCR synthesis of optimally designed, compact, multi-responsive promoters suited to gene therapy application
    Mohamed H, Chernajovsky Y and Gould D
    Scientific Reports, Nature Publishing Group: Open Access Journals - Option C vol. 6, 29388-29388.  
    08-07-2016
  • Local and Sustained Activity of Doxycycline Delivered with Layer-by-Layer Microcapsules
    Luo D, Gould DJ and Sukhorukov GB
    Biomacromolecules, American Chemical Society vol. 17 (4), 1466-1476.  
    11-03-2016

2015

  • Effects of APC De-Targeting and GAr Modification on the Duration of Luciferase Expression from Plasmid DNA Delivered to Skeletal Muscle
    Subang MC, Fatah R, Wu Y, Hannaman D, Rice J, Evans CF, Chernajovsky Y and Gould D
    Current Gene Therapy, Bentham Science Publishers vol. 15 (1), 3-14.  
    01-01-2015
  • Improved and targeted delivery of bioactive molecules to cells with magnetic layer-by-layer assembled microcapsules
    Pavlov AM, Gabriel SA, Sukhorukov GB and Gould DJ
    Nanoscale, Royal Society of Chemistry (Rsc) vol. 7 (21), 9686-9693.  
    01-01-2015

2014

  • A comparative study of matrix metalloproteinase and aggrecanase mediated release of latent cytokines at arthritic joints.
    Mullen L, Adams G, Foster J, Vessillier S, Köster M, Hauser H, Layward L, Gould D and Chernajovsky Y
    Ann Rheum Dis vol. 73 (9), 1728-1736.  
    01-09-2014
  • Identification of ZDHHC14 as a novel human tumour suppressor gene.
    Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Marzec J, Vasiljević N, Chaplin T, Xue L, Xu M, Foster JM, Karnam SS, James SY, Chioni A-M, Gould D, Lorincz AT, Oliver RTD, Chelala C, Thomas GM, Shipley JM, Mather SJ, Berney DM, Young BD and Lu Y-J
    J Pathol vol. 232 (5), 566-577.  
    01-04-2014
  • Generation of an efficiently secreted, cell penetrating NF-κB inhibitor.
    Koutsokeras A, Purkayastha N, Rigby A, Subang MC, Sclanders M, Vessillier S, Mullen L, Chernajovsky Y and Gould D
    Faseb J vol. 28 (1), 373-381.  
    01-01-2014
  • Identification of ZDHHC14 as a novel human tumour suppressor: gene
    Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Marzec J, Vasiljevic N, Chaplin T, Foster JM, Kamam S, Chioni A-M, Gould D, Lorincz AT, Oliver T, Chelala C, Thomas GM, Mather S, Berney D, Young BD and Lu Y-J
    International Journal of Molecular Medicine vol. 34, S90-S90.  
    01-01-2014
  • Latency can be conferred to a variety of cytokines by fusion with latency-associated peptide from TGF-β.
    Mullen L, Rigby A, Sclanders M, Adams G, Mittal G, Colston J, Fatah R, Subang C, Foster J, Francis-West P, Köster M, Hauser H, Layward L, Vessillier S, Annenkov A, Al-Izki S, Pryce G, Bolton C, Baker D, Gould DJ and Chernajovsky Y
    Expert Opin Drug Deliv vol. 11 (1), 5-16.  
    01-01-2014
  • Latent cytokines for targeted therapy of inflammatory disorders.
    Mullen L, Adams G, Layward L, Vessillier S, Annenkov A, Mittal G, Rigby A, Sclanders M, Baker D, Gould D and Chernajovsky Y
    Expert Opin Drug Deliv vol. 11 (1), 101-110.  
    01-01-2014

2013

  • Location of molecules in layer-by-layer assembled microcapsules influences activity, cell delivery and susceptibility to enzyme degradation.
    Pavlov AM, Sukhorukov GB and Gould DJ
    J Control Release vol. 172 (1), 22-29.  
    28-11-2013
  • Gene doping: gene delivery for olympic victory.
    Gould D
    Br J Clin Pharmacol vol. 76 (2), 292-298.  
    01-08-2013
  • Therapeutic Improvement of a Stroma-Targeted CRAd by Incorporating Motives Responsive to the Melanoma Microenvironment
    Viale DL, Cafferata EG, Gould D, Rotondaro C, Chernajovsky Y, Curiel DT, Podhajcer OL and Lopez MV
    Journal of Investigative Dermatology, Elsevier vol. 133 (11), 2576-2584.  
    19-04-2013
  • Lessons in microcapsule assembly from imaging delivery of a bioluminescent enzyme.
    Pavlov AM, Sukhorukov GB and Gould DJ
    Biomacromolecules vol. 14 (3), 608-612.  
    11-03-2013

2012

  • The peritoneal tumour microenvironment of high-grade serous ovarian cancer.
    Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D, Ennis DP, Lockley M, McNeish IA, Nourshargh S and Balkwill FR
    J Pathol vol. 227 (2), 136-145.  
    01-06-2012
  • Abstract 4858: Identification of ZDHHC14 as a novel tumor suppressor gene commonly downregulated in human cancers
    Yeste-Velasco M, Mao X, Grose R, Kudahetti SC, Lin D, Chaplin T, Xue L, Xu M, Foster JM, James S, Chioni AM, Jeetle S, Vasiljević NA, Marzec J, Gould D, Jones L, Lorincz AT, Oliver RTD, Mather SJ, Shipley JM, Berney DM, Young BD and Lu Y-J
    Cancer Research, American Association For Cancer Research (Aacr) vol. 72 (8_Supplement), 4858-4858.  
    15-04-2012
  • A novel hybrid promoter responsive to pathophysiological and pharmacological regulation.
    Subang MC, Fatah R, Bright C, Blanco P, Berenstein M, Wu Y, Podhajcer OL, Winyard PG, Chernajovsky Y and Gould D
    J Mol Med (Berl) vol. 90 (4), 401-411.  
    01-04-2012

2011

2010

  • Quantitative imaging of cartilage and bone for functional assessment of gene therapy approaches in experimental arthritis
    Stok KS, Noel D, Apparailly F, Gould D, Chernajovsky Y, Jorgensen C and Muller R
    J Tissue Eng Regen M vol. 4 (5), 387-394.  
    01-07-2010
  • Human single-chain variable fragment that specifically targets arthritic cartilage.
    Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil N, Marrelli A, Gould D, Subang C, Al-Kashi A, De Bari C, Winyard P, Chernajovsky Y and Nissim A
    Arthritis Rheum vol. 62 (4), 1007-1016.  
    01-04-2010

2009

  • Dual luciferase labelling for non-invasive bioluminescence imaging of mesenchymal stromal cell chondrogenic differentiation in demineralized bone matrix scaffolds
    Vilalta M, Jorgensen C, Degano IR, Chernajovsky Y, Gould D, Noel D, Andrades JA, Becerra J, Rubio N and Blanco J
    Biomaterials vol. 30 (28), 4986-4995.  
    01-10-2009
  • Tumor associated stromal cells play a critical role on the outcome of the oncolytic efficacy of conditionally replicative adenoviruses
    Lopez MV, Viale DL DL, Cafferata EG, Bravo AI, Carbone C, Gould D, Chernajovsky Y and Podhajcer OL
    Plos One vol. 4 
    01-01-2009

2008

  • Biodistribution, Long-term Survival, and Safety of Human Adipose Tissue-derived Mesenchymal Stem Cells Transplanted in Nude Mice by High Sensitivity Non-invasive Bioluminescence Imaging
    Vilalta M, Degano IR, Bago J, Gould D, Santos M, Garcia-Arranz M, Ayats R, Fuster C, Chernajovsky Y, Garcia-Olmo D, Rubio N and Blanco J
    Stem Cells Dev vol. 17 (5), 993-1003.  
    01-10-2008
  • Repopulation of B-lymphocytes with restricted gene expression using haematopoietic stem cells engineered with lentiviral vectors.
    Taher TE, Tulone C, Fatah R, D'Acquisto F, Gould DJ and Mageed RA
    Gene Ther vol. 15 (13), 998-1006.  
    01-07-2008

2007

  • Novel delivery methods to achieve immunomodulation.
    Gould DJ and Chernajovsky Y
    Curr Opin Pharmacol vol. 7 (4), 445-450.  
    01-08-2007
  • Inflammation-inducible anti-TNF gene expression mediated by intra-articular injection of serotype 5 adeno-associated virus reduces arthritis
    Khoury M, Adriaansen J, Vervoordeldonk MJBM, Gould D, Chernajovsky Y, Bigey P, Bloquel C, Scherman D, Tak PP, Jorgensen C and Apparailly F
    J Gene Med vol. 9 (7), 596-604.  
    01-07-2007
  • The inflammatory cytokine tumor necrosis factor-alpha generates an autocrine tumor-promoting network in epithelial ovarian cancer cells
    Kulbe H, Thompson R, Wilson JL, Robinson S, Hagemann T, Fatah R, Gould D, Ayhan A and Balkwill F
    Cancer Res vol. 67 (2), 585-592.  
    15-01-2007
  • Gene therapy with an improved doxycycline-regulated plasmid encoding a tumour necrosis factor-alpha inhibitor in experimental arthritis
    Gould D, Yousaf N, Fatah R, Subang MC and Chernajovsky Y
    Arthritis Res Ther vol. 9 (1) 
    01-01-2007
  • Reduction of arthritis following intra-articular administration of an adeno-associated virus serotype 5 expressing a disease-inducible TNF blocking agent
    Adriaansen J, Khoury M, de Cortie CJ, Fallaux FJ, Bigey P, Scherman D, Gould D, Chernajovsky Y, Apparailly F, Jorgensen C, Vervoordeldonk MJBM and Tak PP
    Ann Rheum Dis vol. 66, 1143-1150.  
    01-01-2007

2006

  • Expression of a suicidal gene under control of the human secreted protein acidic and rich in cysteine (SPARC) promoter in tumor or stromal cells led to the inhibition of tumor cell growth
    Lopez MV, Blanco P, Viale DL, Cafferata EG, Carbone C, Gould D, Chernajovsky Y and Podhajcer OL
    Mol Cancer Ther vol. 5 (10), 2503-2511.  
    01-10-2006
  • Expression of suicidal gene under control of the human SPARC promoter in tumor or stromal cells led to the inhibition of tumor cell growth
    CHERNAJOVSKY Y, Gould D, Podhajcer OL, Cafferata EA, Carbone C, Viale D, Blanco P and Lopez MV
    Mol. Cancer Ther. vol. 5 (10), 2503-2511.  
    01-10-2006

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