Programme and Abstracts

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Thursday 11th April 2019

08:00-08:50 Coffee, Registration, Poster set-up 
08:50-09:00 Opening: Anthony Bull
09:00-09:30 Keynote Lecture 1 Chair:  Rob Krams
  Yiannis Ventikos , UCL, London, UK
The role of blood flow and inflammation on cerebral aneurysm formation.
09:30-10:45 Cellular mechanosensors Chairs: Hanjoong Jo and J. Serbanovic-Canic
09:30-09:50 Ellie Tzima , Oxford University, UK
The role of PECAM1 in mechano-sensing
09:50-10:10 David Beech, University of Leeds, UK
Piezo-1 and calcium in mechano-sensing
10:10-10:30 Julien Vermot, IGBMC, France
Cilia and their role in mechano-sensing
10:30-10:45 John Tarbell, New York, USA
The role of the mechanosensing endothelial glycocalyx in matrix stiffness-mediated vascular disease
10:45-11:15 Coffee break
11:15-13:00 Mechano Predictors of Atherosclerosis. Chairs: John Oshinski and Peter Weinberg 
11:15-11:35 Ranil de Silva, Imperial College London, UK
Evaluation of shear stress and strain in pig coronaries
11:35-11:55 Peter Stone, Harvard University, US
Spatial relationships among local endothelial shear stress, minimal luminal area, and near-infrared spectroscopy lipid signal in patients with coronary artery disease:Implications for plaque destabilization
11:55-12:15 Martin Schwartz, Yale, Manchester, UK/USA
The role of NFkB in mechanotransduction
12:15-12:30 Stephane Avril, Fr
On the role played by wall shear stress in the alteration of biomechanical properties of ascending thoracic aortic aneurysms
12:30-12:45 Eline Hartman, ErasmusMC, The Netherlands
The synergistic effect of NIRS-detected lipid-rich plaque and five different wall shear stress metrics on human coronary plaque growth
12:45-13:00 Blanca Tardajos Ayllón, Sheffield, UK
c-Rel drives atherosclerosis at sites of disturbed blood flow by activating inflammatory and proliferative transcriptional programmes in endothelium.
13:00-14:30 Lunch and Poster Session 1
14:30-15:55 Imaging of Blood Vessels Chairs: Kim van der Heiden and Ton van der Steen
14:30-14:50 Antoniadis Charalambos, Oxford University, UK
Non-invasive imaging of perivascular fat to predict events.
14:50-15:10 Rene Botnar, King’s College London, UK
Molecular Imaging of advanced plaques.
15:10-15:25 Habib Samedy, Emory Hospital, Atlanta, USA
High Coronary Shear Stress in Patients With Coronary Artery Disease Predicts Myocardial Infarction
15:25-15:40 Yichen Ding, USA
Integrating Light-Sheet Imaging with Advanced Computation to Recapitulate Developmental Cardiac Mechanics
15:40-15:55 Jason Tarkin, Cambridge, UK
Coronary artery inflammation compared to wall shear stress, plaque composition and peri-coronary adipose tissue using PET-CT
15:55-16:25 Coffee break
16:25-17:20 Gender and Cardiovascular Disease  Chairs: Steve White and Jolanda Wentzel
16:25-16:45 Hester den Ruijter, UMCU, NL
Gender differences in CVD- plaque erosion.
16:45-17:05 T Christian Gasser, KTH Royal Institute of Technology
Gender differences in AAA
17:05-17:20 Francoise Lenfant, Inserm, Toulouse, Fr
Gender differences in blood flow-mediated remodeling
17:20-21:00 Conference Dinner and Drinks -

Friday 12th April 2019

08:00-08:50  Coffee, Thea and Poster Session
08:50-09:00 Opening: Peter Weinberg 
09:00-09:30 Keynote Lecture 2 Chair: Paul Evans
  Michael Simons, Yale, USA
Cell fate and aortic aneurysm
09:30-10:25 Pulse Wave Analysis Chairs: Jordi Alastruey and Frank Gijsen
09:30-09:50 Kim Parker, Imperial College London, UK
Future Directions for Wave Intensity Analysis
09:50-10:10 Peter Weinberg, Imperial College London, UK
A non-invasive method for measurement of arterial wave speed, intensity and refections
10:10-10:25 Sam Vennin, KCL, UK
Ventricular dynamics is a main determinant of the augmentation index: An in in vivo and in silico study
10:25-11:00 Coffee break
11:00-12:25 What is the cause of plaque destabilization? Chairs: Peter Stone and Christina Warboys
11:00-11:20 Patrick Segers, University of Ghent, BE
Wall shear stress and plaque development: did we buy a pig in a poke
11:20-11:40 Martin Bennet, Cambridge University, UK 
Wall stress is the main determinant of plaque rupture
11:40-11:55 Sandro Satta, Manchester, UK
A pivotal role for Nrf2 in endothelial detachment– implications for endothelial erosion of stenotic plaques
11:55-12:10 Christos Bourantas, QMUL/UCL, UK
Prognostic implications of endothelial shear stress distribution estimated in three-dimensional quantitative coronary angiography models: A combined analysis of the PROSPECT and IBIS 4 studies
12:10-12:25 Ali C. Akyildiz, ErasmusMC, The Netherlands
Mechanical Predictors of Atherosclerotic Plaque Rupture Beyond “Where Stress, There is Rupture”
12:25-14:00 Lunch and Poster Session 2
14:00-15:30 Cellular Signaling Chairs: Rob Krams and Maria Fragiadaki
14:00-14:20 Holger GerhardtMax-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), DU
Creating and breaking symmetry in vascular networks
14:20-14:40  Thomas Webb, Leicester, UK
JCAD, a human coronary artery disease gene, is a novel regulator of endothelial hippo signaling
14:40-15:00 Paul Evans, Sheffield University, UK
Notch signaling in mechanotransduction
15:00-15:15 Nicole van Engeland, Eindhoven, the Netherlands
Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic forces
15:15-15:30 Christina Warboys, Imperial College, UK
Inflammatory Activation of Endothelial Cells Induced by Disturbed Flow is Regulated by Frizzled-4 and β-catenin via a Non-Canonical Pathway
15:30-16:00 Awards, closing and drinks