Programme and Abstracts
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Thursday 11th April 2019
| 08:00-08:50 | Coffee, Registration, Poster set-up | |
| 08:50-09:00 | Opening: Anthony Bull | |
| 09:00-09:30 | Keynote Lecture 1 | Chair: Rob Krams |
| Yiannis Ventikos , UCL, London, UK The role of blood flow and inflammation on cerebral aneurysm formation. |
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| 09:30-10:45 | Cellular mechanosensors | Chairs: Hanjoong Jo and J. Serbanovic-Canic |
| 09:30-09:50 | Ellie Tzima , Oxford University, UK The role of PECAM1 in mechano-sensing |
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| 09:50-10:10 | David Beech, University of Leeds, UK Piezo-1 and calcium in mechano-sensing |
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| 10:10-10:30 | Julien Vermot, IGBMC, France Cilia and their role in mechano-sensing |
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| 10:30-10:45 | John Tarbell, New York, USA The role of the mechanosensing endothelial glycocalyx in matrix stiffness-mediated vascular disease |
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| 10:45-11:15 | Coffee break | |
| 11:15-13:00 | Mechano Predictors of Atherosclerosis. | Chairs: John Oshinski and Peter Weinberg |
| 11:15-11:35 | Ranil de Silva, Imperial College London, UK Evaluation of shear stress and strain in pig coronaries |
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| 11:35-11:55 | Peter Stone, Harvard University, US Spatial relationships among local endothelial shear stress, minimal luminal area, and near-infrared spectroscopy lipid signal in patients with coronary artery disease:Implications for plaque destabilization |
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| 11:55-12:15 | Martin Schwartz, Yale, Manchester, UK/USA The role of NFkB in mechanotransduction |
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| 12:15-12:30 | Stephane Avril, Fr On the role played by wall shear stress in the alteration of biomechanical properties of ascending thoracic aortic aneurysms |
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| 12:30-12:45 | Eline Hartman, ErasmusMC, The Netherlands The synergistic effect of NIRS-detected lipid-rich plaque and five different wall shear stress metrics on human coronary plaque growth |
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| 12:45-13:00 | Blanca Tardajos Ayllón, Sheffield, UK c-Rel drives atherosclerosis at sites of disturbed blood flow by activating inflammatory and proliferative transcriptional programmes in endothelium. |
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| 13:00-14:30 | Lunch and Poster Session 1 | |
| 14:30-15:55 | Imaging of Blood Vessels | Chairs: Kim van der Heiden and Ton van der Steen |
| 14:30-14:50 | Antoniadis Charalambos, Oxford University, UK Non-invasive imaging of perivascular fat to predict events. |
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| 14:50-15:10 | Rene Botnar, King’s College London, UK Molecular Imaging of advanced plaques. |
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| 15:10-15:25 | Habib Samedy, Emory Hospital, Atlanta, USA High Coronary Shear Stress in Patients With Coronary Artery Disease Predicts Myocardial Infarction |
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| 15:25-15:40 | Yichen Ding, USA Integrating Light-Sheet Imaging with Advanced Computation to Recapitulate Developmental Cardiac Mechanics |
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| 15:40-15:55 | Jason Tarkin, Cambridge, UK Coronary artery inflammation compared to wall shear stress, plaque composition and peri-coronary adipose tissue using PET-CT |
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| 15:55-16:25 | Coffee break | |
| 16:25-17:20 | Gender and Cardiovascular Disease | Chairs: Steve White and Jolanda Wentzel |
| 16:25-16:45 | Hester den Ruijter, UMCU, NL Gender differences in CVD- plaque erosion. |
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| 16:45-17:05 | T Christian Gasser, KTH Royal Institute of Technology Gender differences in AAA |
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| 17:05-17:20 | Francoise Lenfant, Inserm, Toulouse, Fr Gender differences in blood flow-mediated remodeling |
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| 17:20-21:00 | Conference Dinner and Drinks - | |
Friday 12th April 2019
| 08:00-08:50 | Coffee, Thea and Poster Session | |
| 08:50-09:00 | Opening: Peter Weinberg | |
| 09:00-09:30 | Keynote Lecture 2 | Chair: Paul Evans |
| Michael Simons, Yale, USA Cell fate and aortic aneurysm |
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| 09:30-10:25 | Pulse Wave Analysis | Chairs: Jordi Alastruey and Frank Gijsen |
| 09:30-09:50 | Kim Parker, Imperial College London, UK Future Directions for Wave Intensity Analysis |
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| 09:50-10:10 | Peter Weinberg, Imperial College London, UK A non-invasive method for measurement of arterial wave speed, intensity and refections |
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| 10:10-10:25 | Sam Vennin, KCL, UK Ventricular dynamics is a main determinant of the augmentation index: An in in vivo and in silico study |
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| 10:25-11:00 | Coffee break | |
| 11:00-12:25 | What is the cause of plaque destabilization? | Chairs: Peter Stone and Christina Warboys |
| 11:00-11:20 | Patrick Segers, University of Ghent, BE Wall shear stress and plaque development: did we buy a pig in a poke |
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| 11:20-11:40 | Martin Bennet, Cambridge University, UK Wall stress is the main determinant of plaque rupture |
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| 11:40-11:55 | Sandro Satta, Manchester, UK A pivotal role for Nrf2 in endothelial detachment– implications for endothelial erosion of stenotic plaques |
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| 11:55-12:10 | Christos Bourantas, QMUL/UCL, UK Prognostic implications of endothelial shear stress distribution estimated in three-dimensional quantitative coronary angiography models: A combined analysis of the PROSPECT and IBIS 4 studies |
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| 12:10-12:25 | Ali C. Akyildiz, ErasmusMC, The Netherlands Mechanical Predictors of Atherosclerotic Plaque Rupture Beyond “Where Stress, There is Rupture” |
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| 12:25-14:00 | Lunch and Poster Session 2 | |
| 14:00-15:30 | Cellular Signaling | Chairs: Rob Krams and Maria Fragiadaki |
| 14:00-14:20 | Holger Gerhardt, Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), DU Creating and breaking symmetry in vascular networks |
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| 14:20-14:40 | Thomas Webb, Leicester, UK JCAD, a human coronary artery disease gene, is a novel regulator of endothelial hippo signaling |
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| 14:40-15:00 | Paul Evans, Sheffield University, UK Notch signaling in mechanotransduction |
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| 15:00-15:15 | Nicole van Engeland, Eindhoven, the Netherlands Vimentin regulates Notch signaling strength and arterial remodeling in response to hemodynamic forces |
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| 15:15-15:30 | Christina Warboys, Imperial College, UK Inflammatory Activation of Endothelial Cells Induced by Disturbed Flow is Regulated by Frizzled-4 and β-catenin via a Non-Canonical Pathway |
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| 15:30-16:00 | Awards, closing and drinks | |