Advances in AFM force measurements

Felix Rico
Aix-Marseille Universite, CNRS, INSERM, France

Engineering Seminar Series, IOB, MRI, and Colloids & Interfaces Webinars
28th April 2021, 15:00-16:00

Advances in tip technology and the speeds applied in AFM force measurements have enabled exploration of protein unfolding and protein-protein interactions not previously possible. With increasing speeds however it is also necessary to develop the theories for extracting data from the measurements. It is time to revisit assumptions of normal operation that were considered relatively safe before – is Reynolds number still low?, is viscosity constant, should we worry about inertial terms of water? I will show the properties of modern high-speed AFM tips and the theoretical models used to extract molecular force interactions from AFM measurements. I will also cover applications for biomolecular interactions we have discovered in our lab and end with where the potential is for such measurements in the near future.

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Updated by: Radomir Slavchov