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Precision Macromolecular Synthesis and the GlycoCode

Date: Wed 18 Nov 2015, 15:00 - 16:00

Location: PP1 Lecture Theatre, People's Palace, Mile End

Dr Remzi Becer, SEMS

Sequence controlled polymers have been attracting more and more attention to deliver the desired properties to the advanced materials by the help of their precisely controlled compositions and architectures.1 Development of various controlled radical polymerization techniques and ?click? reactions provide a sufficient platform to prepare functional polymers.
Understanding the specific multivalent carbohydrate-protein interactions is crucial to determine the structure-property relationships and to design accordingly the next generation of functional glycomaterials. Therefore, we investigate the structure-property relationships between the mammalian lectins and multivalent carbohydrate polymers, which may have applications for anti-adhesion therapy. Moreover, we have investigated the affinity of poly(mannose-methacrylate), helical glycocopolypeptides, gp120, start shaped glycopolymers, and cyclodextrin centered glycopolymers with a selected mannose binding lectin (DC-SIGN) that exists on dendritic cells, using SPR technique.2-5 Selected members of a glycopolymer library were used to demonstrate the interactions between DC-SIGN and mannose rich polymers. We extend this study to a broader set of polymers to examine the effect of chain length, end group, architecture, thermoresponsive block, and number of arms in the star shaped polymers on the lectin binding.

Website:www.bioengineering.qmul.ac.uk/