Professor Lei Zheng, Clinical Biosensor Research in Southern Medical University
Date: Tue 27 Jan 2015, 13:15 - 14:15
Location: SEMS Seminar Room (Third Floor Engineering)
Professor Lei Zheng is currently director and supervisor of Ph.D. candidates of the department of laboratory medicine, Nanfang Hospital, Southern Medical University, and is the dean of laboratory of circulating biomarkers of Nanfang Hospital.
Title: Clinical Biosensor Research in Southern Medical University
Abstract: Southern Medical University (SMU),established in 1951, now ranks the 5th in Chinese medical universities. She has 6 affiliated hospitals. Nanfang Hospital is the first and the biggest affiliated hospital, which has 2225 beds now. The hospital has 16 State Key Clinical Specialties, one academic of the Chinese Science Academy, and great influence on clinical research. The Department of Laboratory Medicine is one of the State Key Clinical Specialties in Nanfang Hospital, which is one of the leading departments in Chinese Association Laboratory Medicine. Clinical biosensor research is one of the most important research fields in the Department of Laboratory Medicine. In recent years, we have focused on the electrochemical biosensors for circulating biomarkers in cancer and infectious diseases.
We developed an electrochemical enzyme-linked immunosorbent assay method for alpha-fetoprotein based on glucose detection with multienzyme-nanoparticle amplification. Since BRAF V600E mutation detection is demanded for the application of RAF kinase inhibitors or anti-EGFR therapies for many cancers, like the metastasis melanoma, colorectal cancer, lung cancer, et al, we developed a sensitive electrochemical assay for BRAF V600E mutation based on an amplification–refractory mutation system coupled with multi-enzyme functionalized Fe3O4/Au nanoparticles. Base on this study, we are now trying to explore an ultrasensitive biosensor for microRNAs detection based on isothermal strand-displacement polymerase reaction and functionalized magnetic microcarrier. In infectious disease, we also developed a electrochemical molecular beacon detection system for HIV-1 gag gene in homogenous solution.
We are both interested in developing future collaboration between QUML and SMU in biosensors exploration and application.