Dr. Sarah Cartmell (University of Manchester) 'Advances in Orthopaedic Tissue Engineering'
Date: Mon 13 Feb 2012, 10:15 - 11:00
Location: SEMS Seminar Room
Title: 'Advances in Orthopaedic Tissue Engineering'
There is a significant need for novel therapeutic approaches to treat orthopaedic defects such as osteoarthritis and non union fractures.
Tissue engineering is an emerging therapy that offers potential in this area. This presentation will cover several novel approaches to tissue engineering. The optimisation of a perfusion coculture bioreactor for osteochondral constructs will be described using a lattice boltzman model and subsequent validation. The potential use of statins to promote bone matrix formation in a potential acellular drug release product will also be discussed. In addition, the use of electrical stimulation (in both direct coupling and capacitive stimulation formats) to influence cell growth/differentiation will be presented. Finally, novel techniques to visualise soft tissue sections in 4D at high resolution using correlative CT/fluorescent imaging will be described.