Prof Wen Wang
PhD, CEng, FIMechE, FHEA, FAIMBE, FREng
On this page:
- Current Funded Research Projects
- Current PhD Studentship Projects
- Previous Funded Research Projects
- Previous PhD Studentship Projects
- Other Research Projects
Current Funded Research Projects
Start: 01-03-2020 / End: 28-02-2022
The dynamics of microcapsules in fast liquid-gas flows (i.e., inertial regime) is a fundamental problem that lies in the heart of numerous important applications, such as fast particle/cell sorting, encapsulation, and three-dimensional (3D) cell printing. This project will developed numerical simulation tools and fundamental understanding of the capsule and the two-phase fluid dynamics in inertial flow regimes.
Start: 13-02-2020 / End: 12-08-2021
Start: 01-06-2018 / End: 31-05-2021
A novel instrument will be developed that will revolutionise the ability to monitor cellular processes and cell communication in polarised cells by simultaneously imaging cells apically and basally. This will provide information about apical cell morphology and basal ion concentrations and electrical signals such as cell surface charge and impedance.
Current PhD Studentship Projects
Start: 01-01-2019 / End: 31-12-2022
Start: 01-10-2017 / End: 30-09-2021
Previous Funded Research Projects
Start: 01-09-2015 / End: 31-08-2018
Start: 03-09-2015 / End: 02-09-2017
The aim of the project is to conduct a systematic study of the effects of system parameters, such as the blood flow condition, the particle shape, size etc on the cross-stream migration and margination of microcapsules in blood flows in small arteries.
Start: 20-07-2016 / End: 31-03-2017
Start: 15-08-2015 / End: 15-09-2015
Previous PhD Studentship Projects
Start: 01-09-2016 / End: 30-09-2020
Start: 01-10-2017 / End: 30-09-2020
Start: 01-09-2016 / End: 30-09-2020
Start: 01-10-2015 / End: 30-11-2019
Start: 29-09-2015 / End: 28-09-2019
This new PhD studentship follows on from our previous work highlighting the importance of primary cilia in inflammation. Here we will examine whether mechanical loading is anti-inflammatory due to its effect on reducing primary cilia length. The study will initially focus on articular cartilage for which IL-1B stimulates cartilage degeneration as seen in osteoarthritis. Previous studies have shown that compressive mechanical loading is anti-inflammatory. Studies have shown that primary cilia are required for inflammatory signalling and are also modulated by mechanical loading. This study aims to identify the effect of mechanical loading on IL-1B induced inflammatory signalling and test the hypothesis that mechanical loading modulates IL-1? signalling by regulating primary cilia length and trafficking. PhD Student: Su Fu
Start: 01-09-2015 / End: 01-09-2019
We aim to characterize how the cytoskeleton and ERM proteins polarize their intracellular localization as main driver for directed bleb-based cell migration in cancer cells
Start: 15-09-2014 / End: 14-09-2017
Start: 30-09-2011 / End: 01-10-2015
This PhD studentship examines the mechanical properties of articular chondrocytes and the influence of osmotic pressure. In particular hypo osmotic challenge results in an increase in cell size and associated changes in cell mechanics. The study involves quantification of cellular mechanics using micropipette aspiration and...
Start: 01-10-2012 / End: 30-09-2015
Other Research Projects
Dynamics of microcapsules in inertial two-phase flows that supports research on the microfluidics involved in capsule migration in small channels.
Lipid membranes are interfacial systems employed by living organisms to encapsulate cells and organelles, transmit information, transport molecules, and store energy. Lipids also have many industrial applications, for example in the areas of drug design and targeted delivery, nanotechnology, and biofuel production. This project will focus on computer simulations of membrane systems using the molecular dynamics method. Fundamental physical properties will be investigated using state of the art software and high-performance computing facilities.
Flexible particles (FP) including capsules, vesicles and cells are small droplets enclosed by thin membranes. They are widely found in nature and have numerous applications in food, cosmetic, textile, biomedical and pharmaceutical industries (e.g. drug delivery and release). In many applications FPs are subjected to external...