Healing the fetal membranes after iatrogenic PPROM

The integrity of the fetal membranes that surrounds the baby in the womb during pregnancy are vital for normal development. Once the fetal membranes have ruptured or are damaged, they fail to heal leaving a defect until the end of pregnancy. Bacteria may subsequently ascend from the vagina into the womb, causing infection both to the fetus and mother. This condition is called pre-term premature rupture of the foetal membrane (PPROM), and is a common cause of preterm birth. PPROM also complicates 30% of fetal surgeries that are increasingly being used to treat abnormalities in the unborn baby such as spine, diaphragmatic and placental defects. However, PPROM and subsequent preterm birth compromises the outcome of treated babies, reducing the clinical effectiveness of foetal surgery. There are no clinical solutions to improve healing of the foetal membrane after it ruptures.

Engineering the fetal membranes with bioinspired materials

Every year in the UK, an estimated 1 in 9 babies are born preterm because the fetal membranes (FM) spontaneously rupture too early. This condition is called preterm premature rupture of the fetal membrane (PPROM) and is a common cause of preterm birth. Increasingly also clinicians are treating babies in the womb using fetoscopic and open hysterotomy approaches. However, PPROM complicates over 40% of such surgeries leading to preterm birth in treated babies, reducing the clinical effectiveness of fetal surgery. There are currently no clinical solutions to improve healing of the FM after surgery or after it ruptures spontaneously. We have been investigating the reasons why the fetal membranes do not heal in pregnant women

Engineer the story

Mechanisms and Strategies for Fetal Membrane Weakening and Repair after Trauma

Preterm premature rupture of membranes (PPROM) is the rupture of fetal membranes prior to 37 weeks gestation, and before the onset of labour. PPROM complicates 40% of preterm births, which can result in lifelong disabilities such as respiratory, cardiac and neurological disorders. The causes of PPROM are multifactorial and not well understood.

ISSF Small Grant: Trachea Defects in Babies

Regenerative Biomechanics of Human Body

ISSF Small Grant: Human Amniotic Membrane

Growing the QMUL Virtual Tissue Lab (Westfield Trust and EPSRC IAA).

Funding from SEIF and the Westfield Trust supported the evolutionary development of a virtual, interactive teaching aid called the Virtual Tissue Lab (VTL). The site called www.virtualtissuelab.com encourages level 7 students to experience real-life lessons in academic practice and transferable skills needed for life long learning. Technical skills are ...

EPSRC CASE Studentship with NPL

HydraSense is a SMART device to monitor hydration real-time and non-invasively.

A tissue engineering approach to treat defects in the windpipe of babies with fetal stem cells .

There is a strong clinical need for tissue replacement in infants and children. Most tissue and organ engineering efforts are targeted at adult patients, who suffer from tissue loss because of injury or disease.

Role of matrix fragments and mechanical signals in the development of osteoarthritis (MOHE, Government of Malaysia).

This application examines the competing pathways activated by the fibronectin fragments and dynamic compression. We believe that fibronectin fragments mediate cartilage breakdown through the induction of catabolic signalling cascades and are therefore, potentially the cause of the early damaging effects in osteoarthritis. More…

Potential therapeutic effects of galectin-9 in osteoarthritis (EPSRC).

There is an urgent demand for long-term solutions to improve osteoarthritis (OA) treatment in the ageing population. There are drugs that control pain but none that halt the progression of the disease. Increased intervention efforts, augmented by early diagnosis and integrated physical therapies are therefore needed. This…

Microencapsulation and delivery of CNP in 3D tissue-engineered model (Wolfson Foundation).

Our recent work identified that a natural protein called the C-type Natriuretic Peptide (CNP) maintains homeostatic function in human cartilage. We established that CNP function declines with age and the differences in the mechanism of natriuretic peptide signalling affects the ability of the peptide to function normally. These…

Influence of mechanical conditioning and the C-type natriuretic peptide in the modulation of osteoarthritis (ARUK and AOF)

CNP plays a critical role in the development and regulation of articular cartilage by promoting extracellular matrix production and chondrocyte proliferation. Our previous studies demonstrate that CNP acts to inhibit catabolic signals in response to IL-1?, and that these effects are synergistic with the protective stimuli induced by mechanical ...

HydraSense: SMART device to monitor hydration (EPSRC CASE PhD studentship)

This project will develop a device that can monitor the amount of water a patient has consumed (hydration) and compare to the amount water that is lost (dehydration). This novel device will be as simple as a heart rate monitor that is applied to a person's chest. Our device will measure the amount of water that is actively…