Dr Thomas Iskratsch
Dipl.-Ing. (Equiv. to MSc/MEng), PhD
Research Funding
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Current Funded Research Projects
Funding source: BHF British Heart Foundation |
3D Photoelectrochemical Imaging in Porous Light-Addressable StructuresFunding source: EPSRC Engineering and Physical Sciences Research CouncilStart: 04-01-2021 / End: 03-10-2022 Amount: £202248 |
Funding source: BBSRC Biotechnology and Biological Sciences Research Council |
Previous Funded Research Projects
Mechano-regulation of myofibril formation and cardiac remodellingFunding source: British Heart FoundationStart: 01-01-2015 / End: 31-12-2018 While chemical cues have well-established roles in guiding cell differentiation, there is growing evidence of a role for mechanical stimuli, such as matrix rigidity during heart development and disease. However, the mechanisms that underlie this mechanical signalling remain elusive. Here we will study this by combining cell biology, biophysics and nanotechnology in a three-tiered approach in which we examine the cardiomyocyte response to A) passive resistance and varying rigidity; B) active force; C) no force. Detailed understanding will lead to novel and valuable insights into mechanisms of cardiac mechanosensing and could result in novel or improved therapeutic strategies for cardiac diseases. |