Prof Julien Gautrot
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Current Funded Research Projects
Start: 01-10-2019 / End: 30-09-2023
Engineered Protein Nanosheets at Liquid-Liquid Interfaces for Stem Cell Expansion, Sorting and Tissue EngineeringFunding source: EU Commission - Horizon 2020
Start: 01-09-2018 / End: 31-08-2023
ProLiCell will design the biochemical and mechanical properties of extracellular matrix (ECM) protein nanosheets that can sustain the formation of adhesion protein complexes and support cell proliferation and culture on materials with very weak bulk mechanical properties (liquids).
Start: 01-07-2019 / End: 30-06-2021
Start: 01-03-2018 / End: 28-02-2021
A long standing dogma in cell-based technologies is that bulk mechanical properties of solid substrates are essential to enable cell adhesion, proliferation and differentiation. However, the use of solid materials for cell culture constitutes an important hurdle for the scale up and automation of processes. We recently discovered that protein assembly at liquid-liquid interfaces results in mechanically strong protein layers sustaining cell spreading and directing fate decision. For long term culture, such interfaces lacked toughness and ruptured. This project will develop tough 2D nanocomposites assembled at oil-water interfaces and sustaining long term stem cell culture for applications in regenerative medicine.
Start: 01-10-2017 / End: 30-09-2020
This project focuses on the design of novel crosslinking strategies for silicone materials. These will enable the design of a new generation of silicone based composites with controlle mechanical properties and displaying conductive behaviour. The project will explore the use of these materials for 3D printing.
Previous Funded Research Projects
Start: 01-09-2018 / End: 30-11-2019
Start: 04-02-2019 / End: 03-08-2019
This project proposes to combine a model of cerebral organoid (from the Lancaster laboratory) and a model of microvasculature-on-a-chip (from the Gautrot laboratory), to create the first microvascularised model of brain early development. We will study some of the factors that control the interaction of the two models and the formation of a mature interface between vasculatures and cerebral organoids. This model will be used to mimic neurodegenerative conditions and diseases, and for the development of therapeutic strategies.
Start: 01-12-2017 / End: 30-11-2018
This project aims to study soft tissue mechanics and develop biomimetic model elastomers reproducing key biomechanical features of soft tissues.
Start: 15-05-2018 / End: 31-10-2018
Start: 01-09-2017 / End: 31-08-2018
This project aims to demonstrate the suitability of liquid-liquid interfaces and specifically oil-in-water emulsions for the long term culture of stem cells.
Start: 01-02-2017 / End: 31-01-2018
Start: 20-06-2016 / End: 30-11-2017
Start: 01-07-2017 / End: 14-09-2017
Start: 31-05-2017 / End: 31-05-2017
Start: 01-03-2015 / End: 28-02-2017
Start: 01-08-2016 / End: 31-01-2017
Start: 15-11-2015 / End: 30-04-2016
Start: 01-04-2015 / End: 31-03-2016
In collaboration with FormFormForm Ltd., the company behind the range of silicone-based resins called Sugru, the project will explore the use of graphene to generate heat and electrically conductive silicone based matrices, as well as the application of such composites as anti-corrosion coatings. Achieving high performance for such flexible silicone-based composites, thanks to the exceptional properties of graphene, could open up a wide range of applications for such silicone-based materials. Hence we will explore the use of this new technology to address some of the current challenges in the manufacturing industry.
Start: 01-05-2013 / End: 31-01-2016
Start: 01-09-2015 / End: 13-10-2015
Start: 11-01-2014 / End: 31-03-2015
Previous PhD Studentship Projects
Start: 01-10-2015 / End: 30-09-2019
Start: 01-10-2014 / End: 02-11-2018
Start: 01-10-2013 / End: 30-09-2018
Start: 01-09-2015 / End: 31-08-2018
Start: 01-10-2013 / End: 30-09-2016