Prof David Lee
BSc (Hons), MA, PhD
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Previous Funded Research Projects
Start: 01-08-2019 / End: 31-07-2020
Start: 01-10-2019 / End: 31-03-2020
Start: 01-01-2017 / End: 31-12-2019
Mechno-regulation of genome function to direct stem cell rate
Hydrothermal Biomass Upgrade into Carbon Materials and Leuvinic Acid for Sustainable Catalysis - HydroCat Marie Curie (CIG)Funding source: Commission of the European Community
Start: 01-03-2014 / End: 31-08-2018
SuprHApolymers - Engineering macromolecular self-assembly of hyaluronan (HA)-based glycopolymers with peptidesFunding source: Marie Curie Career Integration Grant (FP7)/European Union
Start: 01-03-2014 / End: 28-02-2018
“SuprHApolymers” project aims to design and synthesize glycopolymers mimicking the composition and structure of hyaluronan (HA), a linear polysaccharide composed of repeating disaccharide units of N-acetyl-glucosamine and glucuronic acid but with many important biological functions. These HA synthetic analogues will be explored for applications in synthetic biology and biomedicine.
Start: 01-04-2016 / End: 30-09-2017
Effect of cell age on cell migration and cytoskeletal reorganization
Start: 01-05-2014 / End: 30-04-2017
Use cytoskeletal morphometrics to characterize cell function, behaviour and pathologies
Start: 01-04-2014 / End: 31-03-2017
The project aims to invetigate the molecular mechanisms between peptides and proteins t create dynamic materials
Start: 01-11-2014 / End: 31-12-2016
Start: 01-09-2007 / End: 31-08-2012
Platform Grant Strategic Research Areas i). Mechanics and mechano-signalling at the sub-cellular, cellular and tissue levels. The response of living cells and tissues to mechanical forces is critical to tissue health and homeostasis. Consequently this field of mechanobiology has enormous potential to be exploited in the development of Tissue Engineering ...
Mechanoregulation of nuclear architecture and genome function: A novel mechanism in stem cell fate (Human Frontier Science Program funded)Funding source: Human Frontier Science Program
Start: 01-06-2009 / End: 31-05-2010
Gene expression can be regulated through alterations in nuclear architecture, providing control of genome function. Mechanical loading induces both nuclear deformation and alteration in gene expression in a variety of cell types. One putative transduction mechanism for this phenomenon involves alterations to nuclear architecture...
Previous PhD Studentship Projects
Start: 01-08-2013 / End: 01-08-2017
The role of membrane-actin adhesion in regulating stem cell viscoelastic properties and blebability during differentiationFunding source: EPSRC
Start: 09-01-2012 / End: 10-01-2015
This PhD examines how chondrogenic differentiation of human mesenchymal stem cells (hMSCs) regulates the interaction between the cell membrane and the actin cortex, thereby controlling cell biomechanics. The thesis also investigates the viscoelastic properties of primary articular chondrocytes and the effect of de...
Other Research Projects
This project addresses the concept that the nucleus acts as a sensor for mechanical stimuli. By characterising biophysical and epigenetic changes as stem cells differentiate, we will identify pathways responsible for the alteration of cellular mechanosensitivity. These can then be targeted to repair defective mechanosensitivity in diseased or aged cells.
Articular cartilage, mechanotransduction, cytoskeletal dynamics, calcium signalling, chondrocytes in agarose gel, confocal microscopy.