Dr Clare Thompson
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Current PhD Studentship Projects
Start: 03-09-2018 / End: 02-09-2022
This China Scholarship Council (CSC) studentship examines the effect of substrate stiffness on primary cilia signalling. Initial studies will examine the effect on chondrocyte cilia expression and IFT-dependent inflammatory signalling.
Development of high throughput imaging screen of compounds effecting primary cilia expression and resulting consequences for cilia function.Funding source: Principal's Scholarship
Start: 04-04-2018 / End: 03-04-2021
A high throughput screen of 1721 FDA approved small molecules will be conducted to identify compounds that regulate cilia expression in primary bovine chondrocytes. We will then test the hypothesis that pharmaceutical manipulation of chondrocyte primary cilia expression regulates mechanosignalling.
Previous Funded Research Projects
Start: 01-09-2014 / End: 30-03-2020
This study tests the hypothesis that pathological alterations in the cartilage microenvironment regulate chondrocyte primary cilia structure leading to changes in cilia signalling which drive cartilage degradation. Increasing evidence suggests that primary cilia and the associated signalling pathways are critical for the health of articular cartilage ...
Development of a synovium-chondrocyte organ-on-a-chip model with integrated biomechanical stimulationFunding source: EPSRC OA Tech Network plus Pump-Priming Project Grant
Start: 01-07-2019 / End: 31-12-2019
We plan to develop an organ-on-a chip microfluidic model to investigate the effects of mechanical stimulation on the interaction between musculoskeletal cells within the joint. This chip will incorporate the multiple cell types seen in cartilage and the surrounding synovial environment to mimic human tissue architecture, cellular microenvironment and signalling.
Start: 01-09-2016 / End: 31-10-2019
A high throughput screen of 1721 FDA approved small molecules will be conducted to identify compounds that regulate cilia expression in primary bovine chondrocytes.
Previous PhD Studentship Projects
Start: 29-09-2015 / End: 28-09-2019
This new PhD studentship follows on from our previous work highlighting the importance of primary cilia in inflammation. Here we will examine whether mechanical loading is anti-inflammatory due to its effect on reducing primary cilia length. The study will initially focus on articular cartilage for which IL-1B stimulates cartilage degeneration as seen in osteoarthritis. Previous studies have shown that compressive mechanical loading is anti-inflammatory. Studies have shown that primary cilia are required for inflammatory signalling and are also modulated by mechanical loading. This study aims to identify the effect of mechanical loading on IL-1B induced inflammatory signalling and test the hypothesis that mechanical loading modulates IL-1? signalling by regulating primary cilia length and trafficking. PhD Student: Su Fu