Prof Alvaro Mata
BSc, MSc, DEng
On this page:
- Current Funded Research Projects
- Current PhD Studentship Projects
- Previous Funded Research Projects
- Other Research Projects
Current Funded Research Projects
Start: 06-04-2018 / End: 15-04-2023
Start: 01-02-2018 / End: 31-01-2021
The integrity of the fetal membranes that surrounds the baby in the womb during pregnancy are vital for normal development. Once the fetal membranes have ruptured or are damaged, they fail to heal leaving a defect until the end of pregnancy. Bacteria may subsequently ascend from the vagina into the womb, causing infection both to the fetus and mother. This condition is called pre-term premature rupture of the foetal membrane (PPROM), and is a common cause of preterm birth. PPROM also complicates 30% of fetal surgeries that are increasingly being used to treat abnormalities in the unborn baby such as spine, diaphragmatic and placental defects. However, PPROM and subsequent preterm birth compromises the outcome of treated babies, reducing the clinical effectiveness of foetal surgery. There are no clinical solutions to improve healing of the foetal membrane after it ruptures.
Start: 01-06-2017 / End: 30-11-2020
The project will look to develop 3D printed polymeric scaffolds capable of acellular mineralization for enhancing integration of implants in maxillofacial applications.
Start: 01-05-2019 / End: 31-10-2020
The project aims to translate a mineralising coating that can be grown on 3D printed implants for bone augmentation of the mandibular area.
Current PhD Studentship Projects
Start: 01-12-2018 / End: 30-11-2021
Every year in the UK, an estimated 1 in 9 babies are born preterm because the fetal membranes (FM) spontaneously rupture too early. This condition is called preterm premature rupture of the fetal membrane (PPROM) and is a common cause of preterm birth. Increasingly also clinicians are treating babies in the womb using fetoscopic and open hysterotomy approaches. However, PPROM complicates over 40% of such surgeries leading to preterm birth in treated babies, reducing the clinical effectiveness of fetal surgery. There are currently no clinical solutions to improve healing of the FM after surgery or after it ruptures spontaneously. We have been investigating the reasons why the fetal membranes do not heal in pregnant women
Previous Funded Research Projects
Start: 01-11-2017 / End: 30-04-2019
Dental enamel has a unique chemical composition and a remarkable well-defined hierarchical structure, which together are responsible for its outstanding properties and critical functionality. Once lost, this tissue cannot be regenerated and is directly involved in a variety of dental problems that affect a large percentage of the world population. ...
Start: 01-08-2013 / End: 31-03-2019
The project aims to develop a new kind of strong and dynamic bioactive materials
Start: 01-04-2014 / End: 31-03-2017
The project aims to invetigate the molecular mechanisms between peptides and proteins t create dynamic materials
Start: 01-07-2016 / End: 14-11-2016
Start: 01-03-2015 / End: 31-08-2016
Bioactive membranes for bone regeneration
Start: 01-10-2015 / End: 31-03-2016
Start: 01-04-2014 / End: 31-03-2015
Development of a hybrid self-assembling gel for cartilage regeneration
Start: 01-03-2013 / End: 28-02-2015
Micro and nanotopographies for bone regeneration
Start: 02-01-2014 / End: 31-01-2015
Development of a novel 3D printing technique to pattern molecules within 3D gels
Other Research Projects
This project aims at controlling and stimulating specific cell behaviours such as adhesion, migration, proliferation, and differentiation through precise nano and micro topographical patterns.
This project aims to develop a novel injectable bioactive matrix for cartilage and bone regeneration. The material is based on a functionalized hyaluronic acid with a thermosensitive segment and bioactive dendrimers capable of providing reversible liquid-to-gel assembly upon temperature change, a biocompatible 3D environment for cell growth, and a cocktail ...
This project takes advantage of self-assembling peptide amphiphiles that assemble into nanofibrous gels that exhibit biomimetic architecture and bioactive signals to guide cell behaviour and biological processes.
This project aims to engineer a novel hybrid platform that integrates micro/nanotechnologies with biomimetic materials science to develop 3D scaffolds/templates that promote osteoblastic differentiation, mineralization, and angiogenesis for bone regeneration applications.
This project aims to develop a new fabrication process to create functional molecular patterns within 3D hydrogels. These anisotropic hydrogels would enable the precise in vitro recreation of complex biological scenarios found in healthy or diseased tissues with applications in drug screening, improve biological studies, and tissue engineering.
Directed self-assembly (DSA) is a strategy to control order in materials across scales by tuning the directionally of self-assembly interactions at the nanoscale. In DSA the positions of self-assembling building blocks are guided by an external input to lead to specific orientation or alignment, introducing hierarchical organization. Examples of external ...
This project aims at designing and utilizing peptide self-assembly to guide the hierarchical assembly of proteins and biopolymers at the molecular, nano, micro, and macroscale into functional materials and devices. Our objective is to use this hybrid strategy to enable materials that exhibit dynamic behaviour, improved mechanical properties, self-healing properties, ...
The project aims to develop structural and functional building blocks to create robust membranes that are tuneable and can orchestrate signalling of biological processes for a variety of tissue engineering applications such as bone, cardiac tissue, or abdominal wall. The development of the membranes takes advantage of the combination of ...