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Dr Thomas Iskratsch
Dipl.-Ing. (Equiv. to MSc/MEng), PhD

 
 
 

Research Impact

 

Recent publications:

2018:

Pandey, P., Hawkes, W., Hu, J., Megone, V.W.,  Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. and Iskratsch, T. Cardiomyocytes sense matrix rigidity through a combination of muscle and non-muscle myosin contractions. Developmental Cell.

2017:

Lee, N., Erisken, C., Iskratsch, T., Sheetz, M., Levine, W., Lu, H. Polymer fiber-based models of connective tissue repair and healing. Biomaterials. 112, 303-312

2016:

Santos, L., Blair, D., Kumari, S., Cammer, M., Iskratsch, T., et al. Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability. Immunol Cell Biol. 94, 981-993

Meacci, G., Wolfenson, H., Liu, S., Stachowiak, M., Iskratsch, T.,  et al. α-actinin links ECM rigidity sensing contractile units with periodic cell edge retractions. Mol Biol Cell. 27, 3471-3479

Wolfenson, H., Meacci, G., Liu, S., Stachowiak, M., Iskratsch, T., et al. Tropomyosin Controls Sarcomere-like Contractions for Rigidity Sensing and Suppressing Growth on Soft Matrices. Nature cell biology 18, 33-42.

2015:

Tabdanov, E., Gondarenko, S., Kumari, S., Liapis, A., Dustin, M. L., Sheetz, M. P., Kam, L. C. and Iskratsch, T., Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells. Integr Biol (Camb), 7, 1272-1284.

2014:

Iskratsch, T., Wolfenson, H. & Sheetz, M.P. Appreciating force and shape: the rise of mechanotransduction in cell biology. Nat Rev Mol Cell Biol 15, 825-33 (2014)

Wolfenson H., Iskratsch T., Sheetz M.P. Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events. Biophys J. 107, 2508-14. doi: 10.1016/j.bpj.2014.10.041 (2014).

Dwyer, J., Pluess, M., Iskratsch, T., dos Remedios, C. et al. The formin FHOD1 in cardiomyocytes. Anat Rec 297, 1560-70 (2014).

Zhang, X., Moore, S. W., Iskratsch, T. & Sheetz, M. P. N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading. J Cell Sci 127, 1394-1405 (2014).

2013:

Iskratsch, T., Yu, C. H., Mathur, A., Liu, S. M. et al. FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration. Dev Cell 27, 545-559 (2013).

Iskratsch, T., Reijntjes, S., Dwyer, J., Toselli, P. et al. Two distinct phosphorylation events govern the function of muscle FHOD3. Cell Mol Life Sci 70, 893-908 (2013).

Lynch, C. D., Lazar, A. M., Iskratsch, T., Zhang, X. et al. Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions. Mol Biol Cell 24, 21-30 (2013).