Dr Thomas Iskratsch
Dipl.-Ing. (Equiv. to MSc/MEng), PhD


Research Impact


Recent publications:


Pandey, P., Hawkes, W., Hu, J., Megone, V.W.,  Gautrot, J., Anilkumar, N., Zhang, M., Hirvonen, L., Cox, S., Ehler, E., Hone, J., Sheetz, M. and Iskratsch, T. Cardiomyocytes sense matrix rigidity through a combination of muscle and non-muscle myosin contractions. Developmental Cell.


Lee, N., Erisken, C., Iskratsch, T., Sheetz, M., Levine, W., Lu, H. Polymer fiber-based models of connective tissue repair and healing. Biomaterials. 112, 303-312


Santos, L., Blair, D., Kumari, S., Cammer, M., Iskratsch, T., et al. Actin polymerization-dependent activation of Cas-L promotes immunological synapse stability. Immunol Cell Biol. 94, 981-993

Meacci, G., Wolfenson, H., Liu, S., Stachowiak, M., Iskratsch, T.,  et al. α-actinin links ECM rigidity sensing contractile units with periodic cell edge retractions. Mol Biol Cell. 27, 3471-3479

Wolfenson, H., Meacci, G., Liu, S., Stachowiak, M., Iskratsch, T., et al. Tropomyosin Controls Sarcomere-like Contractions for Rigidity Sensing and Suppressing Growth on Soft Matrices. Nature cell biology 18, 33-42.


Tabdanov, E., Gondarenko, S., Kumari, S., Liapis, A., Dustin, M. L., Sheetz, M. P., Kam, L. C. and Iskratsch, T., Micropatterning of TCR and LFA-1 ligands reveals complementary effects on cytoskeleton mechanics in T cells. Integr Biol (Camb), 7, 1272-1284.


Iskratsch, T., Wolfenson, H. & Sheetz, M.P. Appreciating force and shape: the rise of mechanotransduction in cell biology. Nat Rev Mol Cell Biol 15, 825-33 (2014)

Wolfenson H., Iskratsch T., Sheetz M.P. Early Events in Cell Spreading as a Model for Quantitative Analysis of Biomechanical Events. Biophys J. 107, 2508-14. doi: 10.1016/j.bpj.2014.10.041 (2014).

Dwyer, J., Pluess, M., Iskratsch, T., dos Remedios, C. et al. The formin FHOD1 in cardiomyocytes. Anat Rec 297, 1560-70 (2014).

Zhang, X., Moore, S. W., Iskratsch, T. & Sheetz, M. P. N-WASP-directed actin polymerization activates Cas phosphorylation and lamellipodium spreading. J Cell Sci 127, 1394-1405 (2014).


Iskratsch, T., Yu, C. H., Mathur, A., Liu, S. M. et al. FHOD1 Is Needed for Directed Forces and Adhesion Maturation during Cell Spreading and Migration. Dev Cell 27, 545-559 (2013).

Iskratsch, T., Reijntjes, S., Dwyer, J., Toselli, P. et al. Two distinct phosphorylation events govern the function of muscle FHOD3. Cell Mol Life Sci 70, 893-908 (2013).

Lynch, C. D., Lazar, A. M., Iskratsch, T., Zhang, X. et al. Endoplasmic spreading requires coalescence of vimentin intermediate filaments at force-bearing adhesions. Mol Biol Cell 24, 21-30 (2013).