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Prof Martin Knight
BEng, MSc, PhD, FHEA

 

Research Impact

Ciliotherapy - Mechanotherapy

Prof Knight's group are interested in structure-function relationships in primary cilia. Consequently we are exploring the potential for small molecule or biomaterial regulation of cilia structure and trafficking as a means of controlling signalling pathways important in the pathogenesis of diseases such as osteoarthritis, inflammation, cancer and obesity and the rare genetic disorder, alkaptonuria and Jeune syndrome. This overlaps with work investigating the potential therapeutic benefits of manipulating cellular mechanosignalling.  

Organ-on-a-Chip Models

Prof Knight is actively involved in the development of organ-on-a-chip technology. These microfluidic models have the potential to transform fundamental biomedical research and the development and testing of new medical products and pharamaceuticals. Prof Knight is the Director of the QM+Emulate Organs-on-chips Centre and works on development of new models including cartilage, synovium, bone, tendon, kidney and breast cancer as well as underpinning technology.   Emulate chip

Silk Meniscal Implants

Prof Knight is involved in biomaterials research, previously working as a scientific consultant with Orthox Ltd (http://www.orthox.co.uk) developing silk based materals for cartilage and meniscal repair. These silk based biomaterials are engineered to have biomechanical properties similar to natural tissue, whilst also allowing new tissue to grow into the body of the implant, potentially enabling a longer term regenerative repair  

 

Public Engagement - promoting Bioengineering and Mechanobiology

Prof Knight has been involved in numerous public engagement activities, particular those aimed at promoting bioengineering to school children. Activities include interactives at the Centre of the Cell, a programme of science animation classs funded by the EPSRC, activities at the Big Bang and other science festivals and appearances on TV documentaries and school programmes.
Click on one of the images to find out more about specific public engagement activities.