Prof Martin Knight
BEng, MSc, PhD, FHEA

 
 
 

Research Impact

Ciliotherapy - Mechanotherapy

Prof Knight's group are interested in structure-function relationships in primary cilia. Consequently we are exploring the potential for small molecule or biomaterial regulation of cilia structure and trafficking as a means of controlling signalling pathways important in the pathogenesis of diseases such as osteoarthritis, inflammation, cancer and obesity and the rare genetic disorder, alkaptonuria. This overlaps with work investigating the potential therapeutic benefits of manipulating cellular mechanosignalling.  

Silk Meniscal Implants

Prof Knight is involved in biomaterials research, working as a scientific consultant with Orthox Ltd (http://www.orthox.co.uk) developing silk based materals for cartilage and meniscal repair. Their meniscal repair device, FibroFix™, replaces damaged tissue removed in a meniscectomy. It is cut to size in theatre by the surgeon and introduced into the knee through the same keyhole incision used to perform the meniscectomy. Once fixed in place, FibroFix™ Meniscus has the biomechanics properties required to assume the role of the tissue removed, whilst also allowing new tissue to grow into the body of the implant, enabling a longer term regenerative repair  

 

Public Engagement - promoting Bioengineering and Mechanobiology

Prof Knight has been involved in numerous public engagement activities, particular those aimed at promoting bioengineering to school children. Activities include interactives at the Centre of the Cell, a programme of science animation classs funded by the EPSRC, activities at the Big Bang and other science festivals and appearances on TV documentaries and school programmes.
Click on one of the images to find out more about specific public engagement activities.