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School of Engineering and Materials Science



MAT311: Tissue Engineering and Regenerative Medicine

Units: 1   Credits: 15   Semesters: A   Level: 6   Fulltime: Y
Year: 2014/15

Prof David Lee

Prof Joost de Bruijn
Description: This specialised course covers a range of topics in Tissue Engineering. It will develop the knowledge base of the student with emphasis on the current research directions of this rapidly emerging topic supported by skills developed in the laboratory. The students will understand the multidisciplinary principles underpinning tissue engineering, They will appreciate principles that underlie behind a series of strategies to repair both tissues and organs. They will be able to apply their engineering background to biological systems. They will develop skills to enable them to be fully conversant with current research.
Method of Delivery (Teaching and Learning Profile):
Course Type: Taught
Approx hours to be spent by students in: Lectures: 33   Seminars: 0   Fieldwork/visits: 0
Lab work: 12   Timetabled project/coursework: 0
Percentage Credit for Examination: 70%    Credit for Coursework: 30%
Aims: Aims of the course:
- To provide an advanced level understanding of the scope of tissue engineering and regenerative medicine
- To develop an understanding of tissue engineering and regenerative medicine as industrial sectors
- To give in-depth knowledge of a variety of tissue engineering and regenerative medicine-based approaches for clinical problems associated with a range of tissues and organs
- To gain practical experience of the manipulation of cells and the formation of tissue engineered constructs utilising mechanical test systems and bioreactors
Objectives: Students will be able to:
Develop knowledge and understanding:

- Demonstrate an understanding of the definitions of tissue engineering and regenerative medicine and to place tissue engineering and regenerative medicine in a historical perspective in the light of biomaterial implants.
-Demonstrate an understanding of the range of cells available for use in tissue engineering and regenerative medicine, their advantages and disadvantages and methods of manipulation.
- Demonstrate and understanding of cell mechanics and its importance to tissue engineering of load bearing tissues.
-Demonstrate an understanding of the range of materials, scaffold designs and bioraeactor systems used in the development of tissue engineered constructs.
-Demonstrate an understanding of current tissue engineered products for use in clinical applications involving skin, cartilage, ligament, tendons, bone and pancreas
-Demonstrate an awareness and ability to manage the implications and values of medical ethics related to tissue engineering.

Develop values and attitudes:

-Recognise the potential impace of tissue engineering and regenerative medicine within healthcare
-Understand the importance of healthcare economics to the success or otherwise of the tissue engineering sector.
-Recognise the importance of ethical issues in tissue engineering and regenerative medicine

Develop cognitive and intellectual skills:

-Evaluate the criteria determining the success of tissue engineering-based systems
-Understand parameters for determining cell sources etc in tissue engineering.

Develop subject specific/professional skills:

-Conduct basic experiments involving the isolation of cells and seeding within 3-D constructs

Develop transferable skills:

-Manipulation and presentation of data obtained during practical work
-Presentation of a business case for development of a tissue engineered product
Syllabus: Introduction to Tissue Engineering
- Definitions of tissue engineering.
- Historical perpectives in the light of biomaterial implants.

Cell Biology
- Cell types, stem cells, intracellular structures.
- Biochemistry and molecular biology.
- Cell growth and differentiation.
- Morphogenesis, control pathways, extracellular matrix, epithelial-mesenchymal interactions, matrix molecules and their ligands, gene expression, concept of mechanotransduction.
- In vitro control of tissue development.
- Cell culture.
- Transplantation of cells, tissues and biomaterials.

Cell Mechanics
- Current direct techniques e.g. cell poking, AFM, pipetter aspiration, and direct methods using cell model, to derive structurural and material properties.
- Typical values for muscle cells, endothelial cells, and chondrocytes.
- Importance of intracellular organelles.
- In vitro synthesis of tissue and organs.
- Kinetics and mass transport, mechanics in musculoskeletal system and wound healing.

Construct Technology
- 3D structures, multi-cellular systems, transport of nutrients/waste products.
- Bioreactor prinicples and performance.
- Monitoring and sensing of tissue engineered systems.

Clinical Applications
- Case studies of skin, bone, cartilage. ligament, tendons and pancreas.
- Tissue engineering industry.
Historical perspectives, owrldwide perspectives. Future prospects for growth.
- Regulatory affairs, FDA and other regulatory bodies.
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