MAT6312: Science of Biocompatibility for 2012/13
This module will provide a comprehensive understanding of the concepts related to biocompatibility. It will cover topics including proteins and protein adsorption, cells and tissue interactions (attachment, fluid shear and mechanotransduction), biomaterial blood and cell interactions, Inflammation, wound healing and foreign body response and Toxicity, hypersensitivity and infection.
The In vitro testing of biomaterials will be considered with respect to
– chemical exchange and degradation
– cell response (proliferation vs differentiation)
– evaluation of material compatibility
– evaluation of device functionality (biomechanics, remodelling/adaptation)
Matters related to clinical trials and regulatory approval will be considered including clean manufacturing, microbiology, packaging and sterility assurance.